Can Pancreatic Organoids Help in the Treatment of Pancreatic Cancer?

Seppälä, Toni T.; Burkhart, Richard A.

doi:10.1016/j.yasu.2021.05.015

Cited by 1 publication

(5 citation statements)

References 39 publications

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“…Over the past several decades, substantial research efforts have been dedicated to identifying and characterizing these genes. 16,18 Their discovery has provided valuable insights into the mechanisms underlying cancer development and progression.…”

Section: Hereditary Cancer Genesmentioning

confidence: 99%

“…BRCA1, BRCA2 are known as high penetrance Ca of which mutations can be found both among men and women. 18,22 MLH1, MSH2, and MSH6, which are responsible for most hereditary forms of hereditary nonpolyposis colon cancer (HNPCC) and are associated with up to a 70% chance of endometrial cancer. 23 The APC and MYH genes, which cause the adenomatous polyposis syndromes.…”

Section: Hereditary Cancer Genesmentioning

confidence: 99%

“…Not only that, but parent of the unaffected sex may also still carry and pass on those genes. 8,16,18 (a) (b)…”

Section: High Risk Individuals For Hereditary Cancermentioning

confidence: 99%

“…This cross-application of knowledge and treatments derived from hereditary cancer research has significantly benefited the understanding and management of a wider range of malignancies beyond the hereditary context. 18 Apart from drugs, globally the cancer research field has developed significantly through use of new equipment and technology of which hereditary cancer. One example of new technology is Next-Generation Sequencing (NGS).…”

Section: Global Perspectives On Hereditary Cancer Researchmentioning

confidence: 99%

“…Along with that, liquid biopsy, also known as fluid biopsy or fluid phase biopsy has gain momentum in detecting cancers. 18,44…”

Section: Global Perspectives On Hereditary Cancer Researchmentioning

confidence: 99%

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Understanding the Hereditary Factors in Cancer- Recent Insights and Developments: An Updated Review

Nowshin

2023

J. of Ad-din Women's Med. Coll.

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Background: Although cancer (Ca) etiology can be multifactorial, it is nearly universally intertwined with genetic mutations that instigate tumor genesis or progression. This updated review aims at describing if this dispute remains meaningful based on a thorough literature survey. Methodology: This updated review was conducted over the last 2.5 decades using 3 (three) search engines: Web of Science (WoS), Pubmed and Science direct that encompassed all associated information and hypothetical considerations, globally, utilizing information from 1998 through 2022. All such, concepts, logically deducted explanations and scientifically assumed points if Ca remains hereditary is the main focus of this review. Results/ Findings: This appraisal on cancer, though yielded some instances of hereditariness in origin, mostly remains of genetic origin. Reportedly, cancers can be passed down from one family member to another through genes, and, may cause by genetic mutation present in eggs or sperms cell during fertilization which are actually considered as hereditary cancer, like breast, colon, and prostate cancer, as well as less common cancers, viz., pancreatic and ovarian cancer. Therefore, understanding the hereditary factors of Ca is critical not only for assessing the genetic contribution to cancer, but also for designing preventive and therapeutic strategies. It allows identifying people who are at a higher risk due to family history and/or genetic makeup, allow early detection through improved surveillance and, more importantly, for tailored therapeutic modality. By addressing recent advancement, this review will provide an overview on the hereditary factors of cancers and/or raising awareness on significant role of development in Ca genetics. The Journal of Ad-din Women's Medical College; Vol. 11 (2), July 2023; p 48-57

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Section: Hereditary Cancer Genesmentioning

confidence: 99%