Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?

İbiş, Muhammed Arif; Aydos, Kaan; Baltacı, Volkan; Aktuna, Süleyman; Yaman, Önder

doi:10.1016/j.androl.2021.04.002

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2023

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“…PCNA, or proliferating cell nuclear antigen, is a factor that is necessary for both the replication and repair of DNA. Research indicates that the downregulation of the PCNA gene is linked to inadequate spermatogenesis [23]. For centrosomes to mature and be properly segregated, a well-known mitotic regulator called Aurora A kinase (AURKA) must be present [24].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Pathogenesis of Cryptorchidism Complicated with Azoospermia via Microarray Data Analysis

2023

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Despite the growing evidence that the presence of cryptorchidism increases the risk of azoospermia, the common mechanisms via which it occurs remain incompletely elucidated. This research was conducted to gain a deeper understanding of the molecular mechanisms that contribute to the onset and progression of this complication. In total, 197 common DEGs (182 down-regulated and 15 upregulated genes) were chosen for further investigation. The significance of cell cycle and metabolic regulation in the onset and progression of both diseases was highlighted by functional analysis. Eventually, nine important hub genes were identified using cystoHubba, including CCNB1, PCNA, AURKA, CCT5, CCT2, STIP1, UBE2N, RUVBL1, and HSF1. Our research elucidates a common pathogenesis between cryptorchidism and azoospermia. These common pathways and hub genes might inspire new avenues of investigation into underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Exploring the Pathogenesis of Cryptorchidism Complicated with Azoospermia via Microarray Data Analysis

2023

FMSR

View full text Add to dashboard Cite

show abstract

Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?

Cited by 1 publication

References 30 publications

Exploring the Pathogenesis of Cryptorchidism Complicated with Azoospermia via Microarray Data Analysis

Exploring the Pathogenesis of Cryptorchidism Complicated with Azoospermia via Microarray Data Analysis

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