Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice?

Tomazoni, Shaiane Silva; Casalechi, Heliodora Leão; Ferreira, Cheila de Sousa Bacelar; Serra, Andrey Jorge; Dellê, Humberto; Brito, Rodrigo Barbosa de Oliveira; Melo, Brunno Lemes de; Vanin, Adriane Aver; Ribeiro, Neide Firmo; Pereira, Amanda Lima; Monteiro, Kadma Karênina Damasceno Soares; Marcos, Rodrigo Labat; Carvalho, Paulo de Tarso Camillo de; Frigo, Lúcio; Leal-Junior, Ernesto César Pinto

doi:10.1371/journal.pone.0236689

Cited by 5 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histopathological examination performed after PBM showed that it can protect myonecrosis, reduce pro-inflammatory cell infiltration, muscle destruction, inflammation and can help accelerate tissue repair [91][92][93]. Six other animal studies with positive effects of PBM and improved muscular function in a dose-and wavelength-dependent manner, the last of which with a simultaneously applied static magnetic field, are presented below [94][95][96][97][98][99].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Photobiomodulation and Sports: Results of a Narrative Review

Ailioaie

Litscher

2021

Life

View full text Add to dashboard Cite

Benefits of photobiomodulation (PBM) have been known for several decades. More recently, PBM applied in sports offers a special chance to support the modeling of the performance and recovery. Increasingly complex physical activities and fierce competition in the world of sports generate a state of psycho-emotional and physical stress that can induce chronic fatigue syndrome, failure in physical training, predisposition to muscle damage, physical and emotional exhaustion etc., for which PBM could be an excellent solution. To evaluate and identify all risk factors and the influence of PBM on health and performance in sport and for a better understanding of its effects, we did a search for “Photobiomodulation and Sports” on PubMed, to update the PBM science applied in sports, and we retained for analysis the articles published from 2014 to date. The term “PBM” is recent, and we did not include previous studies with “low level laser therapy” or “LLLT” before 2014. In the present research, PBM has been shown to have valuable protective and ergogenic effects in 25 human studies, being the key to success for high performance and recovery, facts supported also by 22 animal studies. PBM applied creatively and targeted depending on sport and size of the level of physical effort could perfectly modulate the mitochondrial activity and thus lead to remarkable improvements in performance. PBM with no conclusive results or without effects from this review (14 studies from a total of 39 on humans) was analyzed and we found the motivations of the authors from the perspective of multiple causes related to technological limitations, participants, the protocols for physical activity, the devices, techniques and PBM parameters. In the near future, dose–response experiments on physical activity should be designed and correlated with PBM dose–response studies, so that quantification of PBM parameters to allow the energy, metabolic, immune, and neuro-endocrine modulation, perfectly coupled with the level of training. There is an urgent need to continuously improve PBM devices, delivery methods, and protocols in new ingenious future sports trials. Latest innovations and nanotechnologies applied to perform intracellular signaling analysis, while examining extracellular targets, coupled with 3D and 4D sports motion analysis and other high-tech devices, can be a challenge to learn how to maximize PBM efficiency while achieving unprecedented sports performance and thus fulfilling the dream of millions of elite athletes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Finally, the researchers concluded that only PBMT treatments in combination with corticosteroids or nonsteroidal anti-inflammatory drugs gave promising and optimistic results in the skeletal muscle of mdx mice. Therefore, it opens up a possible future alternative in the treatment of Duchenne muscular dystrophy [96].…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation and Sports: Results of a Narrative Review

Ailioaie

Litscher

2021

Life

View full text Add to dashboard Cite

show abstract

“…Photobiomodulation, formerly called low-level light/laser therapy, is a burgeoning field, which has about 1,500 PubMed citations, most in recent years (25)(26)(27). Over decades, these therapies have been used mostly to treat wound healing, musculoskeletal disorder, and gastrointestinal disorders.…”

Section: Introductionmentioning

confidence: 99%

An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation

et al. 2021

View full text Add to dashboard Cite

Background: The opioid epidemic is a global tragedy even with current treatments, and a novel, safe, and effective treatment would be welcomed. We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a treatment for opioid use disorder.Methods: We enrolled 39 participants with active opioid cravings at 2 sites, 19 received the active treatment which consisted of a 4-min twice weekly (every 3 or 4 days) application of a light-emitting diode at 810 nm with an irradiance of 250 mW/cm2 and a fluence of 60 J/cm2 to the forehead over either the left or right dorsolateral prefrontal cortex with a fluence to the brain of 2.1 J/cm2. Twenty participants received a sham treatment with the same device with foil over the bulb. The side of the treatment was based on Dual-Brain Psychology, which posits that one hemisphere is more affected by past maltreatments and is more prone to anxiety and drug cravings that the other hemisphere. We treated the hemisphere with the more positive hemispheric emotional valence (HEV) by 2 tests for HEV.Results: Our primary outcome was changes in pre-treatment opioid craving scale (OCS) minus baseline, and we found using a mixed model that the active group had a highly significant treatment * time benefit over the sham group, p < 0.0001, effect size at the last follow-up of 1.5. The active treatment benefited those not on buprenorphine as well as those not on it. The TimeLine Follow Back measure of opioid use was significantly better in the actively treated group, p = 0.0001, with an effect size of 0.45. We observed no adverse effects.Conclusion: Active unilateral transcranial photobiomodulation to the brain hemisphere with the better HEV was better than sham in the reduction of opioid cravings and opioid use to a very significant degree in a RCT of 39 participants at 2 independent sites. In the active group those on buprenorphine and those not on it both had improvements in cravings over the study. No adverse responses were reported in either group. ClinicalTrials.gov Identifier: NCT04340622.

show abstract

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Alam,

Karami,

Mohammadikhah

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.

show abstract

Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice?

Cited by 5 publications

References 51 publications

Photobiomodulation and Sports: Results of a Narrative Review

Photobiomodulation and Sports: Results of a Narrative Review

An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Contact Info

Product

Resources

About