“…Furthermore, there are few outcome-based data supporting precisely how IS should be used. Previous investigations themselves have used widely variable procedural parameters with respect to the optimal frequency of sessions, 8,11,14,26,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] target inspiratory volume, 14,40,43,44 whether the target is static or dynamic, 11,14,40,42 when to start IS postoperatively, 11,37,39,40,43,44,47,50 the number of breaths per session, 8,14,26,[36][37][38]42,43,45,46,49,52,53 and duration of breath holds.…”