Can Prenatal Testing in the First Trimester be Performed without Ultrasound?

Merz, Eberhard

doi:10.1055/s-0043-102832

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…There is broad consensus in several ultrasound societies and publications that a detailed first-trimester ultrasound examina-tion should always be performed prior to an NIPT procedure [40,47,48,49,50,51,52].…”

Section: Structural Defects Detectable With 3d Ultrasound In the Firs...mentioning

confidence: 99%

The role of ultrasound in first-trimester screening after the introduction of NIPT as a service of public health insurance – a consensus statement of the Fetal Medicine Foundation (FMF) Germany

Merz¹,

Eiben

Thode³

et al. 2023

Ultraschall Med

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Combined first-trimester screening (FTS) and noninvasive prenatal testing (NIPT) have been proven to be reliable noninvasive procedures to detect the most common chromosomal abnormalities (trisomies 21, 18, 13) in the first trimester. The aim of this paper is to demonstrate the strengths and limitations of these two procedures and to give a consensus statement of the Fetal Medicine Foundation (FMF) Germany on how to use the two techniques in the first trimester after the introduction of NIPT as a service of the statutory health insurance companies in Germany.

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Section: Structural Defects Detectable With 3d Ultrasound In the Firs...mentioning

confidence: 99%

The role of ultrasound in first-trimester screening after the introduction of NIPT as a service of public health insurance – a consensus statement of the Fetal Medicine Foundation (FMF) Germany

Merz¹,

Eiben

Thode³

et al. 2023

Ultraschall Med

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show abstract

“…It can be used with caution in low-risk populations, but it has a higher false positive rate due to decreased pretest probability [17,19]. However, NIPT cannot replace US for detection of anomalies [20].…”

Section: Summary Of Literature Review Introduction/backgroundmentioning

confidence: 99%

ACR Appropriateness Criteria® Second and Third Trimester Screening for Fetal Anomaly

Sussman

Chopra

Pōder

et al. 2021

Journal of the American College of Radiology

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The Appropriateness Criteria for the imaging screening of second and third trimester fetuses for anomalies are presented for fetuses that are low risk, high risk, have had soft markers detected on ultrasound, and have had major anomalies detected on ultrasound.The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

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“…While the NIPT is a high-grade "screening method" in the search for certain chromosomal abnormalities, it cannot be equated with a "diagnostic test" [7,8]. This case shows why medical societies such as DEGUM, ÖGUM and SGUM recommend that a precondition for an NIPT is always a proper ultrasound examination satisfying DEGUM II/III.…”

mentioning

confidence: 99%