2016
DOI: 10.1080/15284336.2016.1184827
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Can Probiotics Reduce Inflammation and Enhance Gut Immune Health in People Living with HIV: Study Designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) Pilot Trials

Abstract: These studies will evaluate the ability of probiotics as a safe and tolerable therapeutic intervention to reduce systemic immune activation and to accelerate gut immune restoration in people living with HIV.

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Cited by 32 publications
(21 citation statements)
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“…Treatment of healthy macaques with VSL#3 increased frequencies of protective mucosal immune cells (IgA-expressing B cells, innate immune cells) and suggested that probiotic treatment would also enhance mucosal vaccination strategies and protection from mucosal infections[111]. Additional human clinical studies evaluating the ability of Visbiome, a multi-strain probiotic similar to VSL#3, to reduce systemic immune activation and inflammation and to restore normal intestinal immune function are currently enrolling in the USA (AIDS Clinical Trials Group A5350; ClinicalTrials.gov NCT02706717) and Canada[112]. …”
Section: Treatments To Restore the Intestinal Microbiomementioning
confidence: 99%
“…Treatment of healthy macaques with VSL#3 increased frequencies of protective mucosal immune cells (IgA-expressing B cells, innate immune cells) and suggested that probiotic treatment would also enhance mucosal vaccination strategies and protection from mucosal infections[111]. Additional human clinical studies evaluating the ability of Visbiome, a multi-strain probiotic similar to VSL#3, to reduce systemic immune activation and inflammation and to restore normal intestinal immune function are currently enrolling in the USA (AIDS Clinical Trials Group A5350; ClinicalTrials.gov NCT02706717) and Canada[112]. …”
Section: Treatments To Restore the Intestinal Microbiomementioning
confidence: 99%
“…Gut reconditioning through probiotic administration could be protective of the gut surface and delay the progression to AIDS [108]. Probiotics, by altering intestinal flora, may induce epithelial healing, and by preventing the decline in CD4 + cell counts may lower the risk of virus transmission and reduce hospitalization for co-infections.…”
Section: Probiotics As a New Therapeutic Approach That Might Impromentioning
confidence: 99%
“…Gori et al reported that, in Highly Active Anti-Retroviral Therapy (HAART)-naïve HIV-infected patients, dietary supplementation with a prebiotic mixture results in the improvement of gut microbiota composition, the reduction of sCD14, CD4 + T-cell activation (CD25), and improved NK cell activity [28]. The study of Kim et al evaluated the ability of probiotics, provided during combined antiretroviral therapy (cART), to reduce inflammation and improve gut immune health in HIV-positive treatment-naïve individuals (PROOV IT I) and in individuals with suboptimal CD4 recovery on cART (PROOV IT II) [108]. …”
Section: Probiotics As a New Therapeutic Approach That Might Impromentioning
confidence: 99%
“…However, now they have now been found to be beneficial in a number of severe conditions such as ulcerative colitis, hepatic encephalopathy, and rheumatoid arthritis . They are being actively studied in HIV‐infected individuals as a benefit to standard highly active antiretroviral therapy . No severe adverse events have been identified in these studies that would be attributable to the probiotic.…”
Section: Myths and Mysteriesmentioning
confidence: 99%