Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

Vaghef-Mehrabany, Elnaz; Maleki, Vahid; Behrooz, Maryam; Ranjbar, Fatemeh; Ebrahimi-Mameghani, Mehrangiz

doi:10.1016/j.clnu.2019.06.004

Cited by 65 publications

(33 citation statements)

References 68 publications

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“…Further, other reviews that have been published have reported on the antidepressant properties of probiotics in a mixture of healthy populations, populations under stress, and populations with other primary psychiatric or non-psychiatric diagnoses (e.g., bowel disorders, fibromyalgia, neurodegenerative disorders, etc.) [ 15 , 16 , 17 ]. However, for probiotics to be considered a viable treatment option for depression, RCT evidence from clinically defined populations with depression rather than with other primary diagnoses is needed.…”

Section: Introductionmentioning

confidence: 99%

Updated Review and Meta-Analysis of Probiotics for the Treatment of Clinical Depression: Adjunctive vs. Stand-Alone Treatment

Nikolova

Cleare

Young

et al. 2021

JCM

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Recent years have seen a rapid increase in the use of gut microbiota-targeting interventions, such as probiotics, for the treatment of psychiatric disorders. The objective of this update review was to evaluate all randomised controlled clinical trial evidence on the efficacy of probiotics for clinical depression. Cochrane guidelines for updated reviews were followed. By searching PubMed and Web of Science databases, we identified 546 new records since our previous review. A total of seven studies met selection criteria, capturing 404 people with depression. A random effects meta-analysis using treatment type (stand-alone vs. adjunctive) as subgroup was performed. The results demonstrated that probiotics are effective in reducing depressive symptoms when administered in addition to antidepressants (SMD = 0.83, 95%CI 0.49–1.17), however, they do not seem to offer significant benefits when used as stand-alone treatment (SMD = −0.02, 95%CI −0.34–0.30). Potential mechanisms of action may be via increases in brain-derived neurotrophic factor (BDNF) and decreases in C-reactive protein (CRP), although limited evidence is available at present. This review offers stronger evidence to support the clinical use of probiotics in depressed populations and provides an insight into the mode of administration more likely to yield antidepressant effects.

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Section: Introductionmentioning

confidence: 99%

Updated Review and Meta-Analysis of Probiotics for the Treatment of Clinical Depression: Adjunctive vs. Stand-Alone Treatment

Nikolova

Cleare

Young

et al. 2021

JCM

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“…Targeting the gut microbiota with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics has become a useful biotherapeutic method for treating various diseases, including neuroinflammation-induced mental illness [26,27] and psychosocial disorders such as depression-and anxiety-like behaviors in humans and related animal models [28,29]. Synbiotics may be more efficient than prebiotics and probiotics, as synbiotics are a synergistic mixture of probiotics and prebiotics.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Mohammed

Mahmoud

Murugesan³

et al. 2021

Animals

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The aim of this study was to evaluate the effect of a synbiotic containing a probiotic (Enterococcus faecium, Pediococcus acidilactici, Bifidobacterium animalis, and Lactobacillus reuteri) and a prebiotic (fructooligosaccharides) on fear response, memory assessment, and selected stress indicators in broilers subjected to heat stress. A total of 360 1-day-old Ross 708 chicks were evenly divided among three treatments: a basal diet mixed with a synbiotic at 0 (G-C), 0.5 (G-0.5X), and 1.0 (G-1.0X) g/kg. After 15 d, the broilers were exposed to 32 °C for 9 h daily until 42 d. The object memory test was conducted at 15 day; touch, novel object, and isolation tests were conducted at 35 day; tonic immobility (TI) took place at 41 day. At 42 day, plasma corticosterone and tryptophan concentrations and heterophile/lymphocyte (H/L) ratios were measured. Compared to controls, synbiotic-fed broilers, regardless of concentration, had a shorter latency to make the first vocalization, with higher vocalization rates during the isolation test (p = 0.001). the G-1.0 group had the lowest H/L ratio (p = 0.001), but higher plasma tryptophan concentrations and a greater number of birds could reach the observer during the touch test (p = 0.001 and 0.043, respectively). The current results indicate that the synbiotic can be used as a growth promoter to reduce the fear response and stress state of heat-stressed broilers.

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“…The general acceptance of the health benefits of prebiotics is based upon metabolic and immunological end-points, but these have seldom been backed up by quality data on healthrelated outcomes in clinical trials in most areas of study, as shown in systematic reviews in several areas of health promotion [11,[13][14][15][16][17][18][19][20][21]. The difficulty in showing benefits might, as discussed above, relate to the lack of consideration to background diet in the design of trials, or it might relate to the fact that the concept is overblown and benefits may be very modest indeed.…”

Section: Author Manuscriptmentioning

confidence: 99%

Review article: FODMAPS, prebiotics and gut health‐the FODMAP hypothesis revisited

Gibson

Halmos

Muir

2020

Aliment Pharmacol Ther

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Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

Cited by 65 publications

References 68 publications

Updated Review and Meta-Analysis of Probiotics for the Treatment of Clinical Depression: Adjunctive vs. Stand-Alone Treatment

Updated Review and Meta-Analysis of Probiotics for the Treatment of Clinical Depression: Adjunctive vs. Stand-Alone Treatment

Effect of a Synbiotic Supplement on Fear Response and Memory Assessment of Broiler Chickens Subjected to Heat Stress

Review article: FODMAPS, prebiotics and gut health‐the FODMAP hypothesis revisited

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