Can psychomotor disturbance predict ect outcome in depression?

Diermen, Linda van; Vanmarcke, Simon; Walther, Sebastian; Moens, H.L. Bernelot; Veltman, E.M.; Fransén, Erik; Sabbe, Bernard; Mast, Roos van der; Birkenhäger, Tom K.; Schrijvers, Didier

doi:10.1016/j.jpsychires.2019.07.009

Cited by 38 publications

(23 citation statements)

References 48 publications

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“…These ndings are in line with results of some studies and contrary to others [30,31]. Retardation is one of the basical features of MDD [32], results of several clinical studies suggested that MDD patients with severer baseline retardation should be treated with electroconvulsive therapy (ECT) as early as possible [33][34][35].…”

Section: Discussionsupporting

confidence: 82%

The combination of serum BDNF, cortisol and IFN-gamma can effectively diagnose major depressive disorder

Chen

Zhang

Yuan

2021

Preprint

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Background Misdiagnosis and ineffective treatment are common in major depressive disorder (MDD) in current clinical practice, while the combination of various proteins involved in the pathogenesis of MDD may assist the correct diagnosis. The study aimed to explore whether the combination of serum inflammatory, stress, and neurotrophic factors could be helpful for the diagnosis of MDD, and to investigate the predictors associated with early symptom improvement. Methods Baseline serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, IL-1beta, tumor necrosis factor (TNF)-alpha, interferon (INF)-gamma, cortisol and brain-derived neurotrophic factor (BDNF) were detected in 30 MDD patients and 30 age- and gender-matched healthy controls. 17-item Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA) were applied to assess depressive and anxious symptoms both at baseline and 2 weeks after antidepressant treatment. Stepwise multiple linear regression was employed to identify the early efficacy predictiors; while a logistic regression model was built with above proteins and area under receiver operating characteristic (AUC) curve was calculated to evaluate the model’s diagnostic power. Results Multiple linear regression revealed that baseline socres of retardation ( β =-0.432, P =0.012) and psychological anxiety ( β =-0.423, P =0.014) factors were negatively associated with the reduction rate of HAMD-17. A simple and efficient diagnostic model was established by forward stepwise logistic regression and the model achieved an AUC of 0.884, with 86.7% sensitivity and 83.3% specificity. Couclusions The results showed that combining serum BDNF, cortisol and IFN-gamma could aid the diagnosis of MDD, while baseline retardation and psychological anxiety may negatively predict the early symptom improvement.

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Section: Discussionsupporting

confidence: 82%

The combination of serum BDNF, cortisol and IFN-gamma can effectively diagnose major depressive disorder

Chen

Zhang

Yuan

2021

Preprint

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“… 44 , 45 Retardation is one of the basic features of MDD, 46 and results of several clinical studies suggested that MDD patients with severe baseline retardation should be treated with electroconvulsive therapy (ECT) as early as possible. 47–49 …”

Section: Discussionmentioning

confidence: 99%

The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder

Chen

Zhang

Yuan

2021

NDT

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“…We excluded patients with a history of substance abuse (<6 months prior) or who had been diagnosed with primary psychotic or schizoaffective disorders. Our study was part of the PRO-TECT study, which was designed to investigate ECT response predictors (41)(42)(43). All patients provided written informed consent before the study procedures were performed.…”

Section: Study Samplementioning

confidence: 99%

Cognitive change after electroconvulsive therapy in mood disorders measured with the Montreal Cognitive Assessment

Hebbrecht

Giltay

Birkenhäger

et al. 2020

Acta Psychiatr Scand

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Objective The Montreal Cognitive Assessment (MoCA) is a sensitive and clinically practical test but its usefulness in measuring long‐term cognitive effects of ECT is unclear. Using the MoCA, we investigated short‐ and long‐term global cognitive change in ECT‐treated patients with a Major Depressive Episode (MDE). Method We included 65 consecutive ECT‐treated patients with MDE, in whom global cognitive functioning was assessed at baseline (T0); during ECT (before the third session; T1); and 1 week (T2), 3 months (T3), and 6 months (T4) after completion of the index course. Changes in MoCA (sub)scores were analyzed using linear mixed models and reliable change indices were computed to investigate individual changes in MoCA total scores. Results There was a significant effect of time on MoCA scores (F(4, 230.5) = 4.14, P = 0.003), with an improvement in global cognitive functioning from T3 compared to T1 and T2. At the individual level, 26% (n = 17) of patients showed a significantly worse cognitive functioning at T2 and 12% (n = 8) an improved cognitive functioning compared to T0. For T4, these percentages ameliorated to 8% and 18% respectively. Conclusion No persistent global cognitive impairment induced by ECT was found at the group level using the MoCA. At the individual level, however, there was clear heterogeneity in the effects of ECT on cognitive functioning. The MoCA is a suitable tool to monitor short‐ and long‐term global cognitive functioning in ECT‐treated patients with MDE but in younger patients, potential ceiling effects must be taken into account.

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Can psychomotor disturbance predict ect outcome in depression?

Cited by 38 publications

References 48 publications

The combination of serum BDNF, cortisol and IFN-gamma can effectively diagnose major depressive disorder

The combination of serum BDNF, cortisol and IFN-gamma can effectively diagnose major depressive disorder

The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder

Cognitive change after electroconvulsive therapy in mood disorders measured with the Montreal Cognitive Assessment

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