Can quercetin be an option for treatment of spinal cord injury?: an experimental study

Öcal, Özgür; Börcek, Alp Özgün; Paşaoğlu, Özge Tuğçe; Gündoğdu, Ayşe; Kaplanoğlu, Gülnur Take; Baykaner, M. Kemali

doi:10.5137/1019-5149.jtn.23799-18.1

Cited by 13 publications

(11 citation statements)

References 14 publications

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“…Schültke et al reported that administration of quercetin in a dose of 0.25 μmol/kg led to a lower MPO expression in damaged spinal cord tissue [72]. In addition, single-dose quercetin within the first 72 hours after SCI enhanced total antioxidant levels and decreased the levels of NO and MDA [73]. In this regard, quercetin also elevated total antioxidant capacity and paraoxonase activity after SCI in rats [74].…”

Section: Polyphenols Target Upstream Mediators Of Oxidative Stress After Scimentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

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Section: Polyphenols Target Upstream Mediators Of Oxidative Stress After Scimentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Quercetin promotes the motor and electrophysiological functional recovery, astrocytic activation, and axonal regeneration after acute SCI ( 140 ). Moreover, it minimizes the formation of cavities at the injured site and pathological damage to nerve tissue, improves post-traumatic spinal cord edema ( 152 ), increases neuronal survival, promotes nerve regeneration ( 153 ), preserves the injured spinal cord tissue ( 154 ), and facilitates motor function recovery ( 139 ). The level of S-100β in serum is associated with the degree of nerve injury, neuroprotection, and regeneration.…”

Section: Quercetin Regulates the Mtor Signaling Pathway To Improve Scimentioning

confidence: 99%

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Wang

Botchway

et al. 2022

Front. Neurol.

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The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress caused by secondary SCI may instigate serious consequences in the event of SCI. The mammalian target of rapamycin (mTOR), as a key signaling molecule, participates in the regulation of inflammation, apoptosis, and autophagy in several processes associated with SCI. Quercetin can reduce the loss of myelin sheath, enhance the ability of antioxidant stress, and promote axonal regeneration. Moreover, quercetin is also a significant player in regulating the mTOR signaling pathway that improves pathological alterations following neuronal injury. Herein, we review the therapeutic effects of quercetin in SCI through its modulation of the mTOR signaling pathway and elaborate on how it can be a potential interventional agent for SCI.

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“…Thus, supporting quercetin as a significant neuroprotective role in preventing brain injury. In an experimental study, administration of quercetin with different doses in 30 male Wistar rats was carried out wherein it was suggested that quercetin could be an alternative for the treatment of spinal cord injury [144]. Kumar et al [145] reported improved neuronal survival after exposure to HgCl 2 using quercetin and caffeine in hippocampal neurons.…”

Section: Quercetin As a Neuroprotective Agentmentioning

confidence: 99%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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Can quercetin be an option for treatment of spinal cord injury?: an experimental study

Cited by 13 publications

References 14 publications

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

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