Can Real-World Evidence Help Restore Decades of Health Inequalities by Informing Health Care Decision-Making? Certainly, and Here is How

Sarri, Grammati

doi:10.3389/fphar.2022.905820

Cited by 7 publications

(10 citation statements)

References 32 publications

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“…Health equity was identified in four articles ( Dionne et al, 2015 ; Cookson et al, 2017 ; Goetghebeur and Cellier, 2018 ; Diaby et al, 2021 ) as an important factor that is largely lacking in the existing HTA frameworks. Equity is defined by the World Health Organization as: “the absence of unfair, avoidable or remediable differences among groups of people, whether those groups are defined socially, economically, demographically, or geographically or by other dimensions of inequality (e.g., sex, gender, ethnicity, disability, or sexual orientation)” ( Organization WH, 2022 ; Sarri, 2022 ). Inequity is thus evident in circumstances where a deficit in one of these areas affects access to affordable care, which is limited in one or more marginalized groups.…”

Section: Resultsmentioning

confidence: 99%

“…In the context of societal values, it was argued that the impact of disease and its characteristics on patients and their productivity should also factor into decision-making. Similarly, patient preferences, addressing the needs of underrepresented groups, and ensuring access to affordable care are central to including equity considerations in HTA frameworks ( Dionne et al, 2015 ; Diaby et al, 2021 ; Sarri, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…Healthcare systems stretched thin by the recent COVID-19 pandemic face ongoing challenges in integrating costs for new therapies into an already strained system ( Epstein et al, 2020 ; Information CIfH, 2022 ; Youn et al, 2022 ). However, recent trends such as the growing use of real-world evidence (RWE) in healthcare research in general and with it a concomitant uptake in the use of RWE in regulatory and HTA agency filings may provide the opportunity to unravel existing health inequalities that directly fit in the decision-making ( Sarri, 2022 ). However, the potential of RWE to capture the direction and magnitude of impact a new health technology may have on health inequalities has not been fully explored ( Goetghebeur and Cellier, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Reconstructing the value puzzle in health technology assessment: a pragmatic review to determine which modelling methods can account for additional value elements

Muir¹,

Radhakrishnan²,

Freitag³

et al. 2023

Front. Pharmacol.

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Health technology assessment (HTA) has traditionally relied on cost-effectiveness analysis (CEA) as a cornerstone of evaluation of new therapies, assessing the clinical validity and utility, the efficacy, and the cost-effectiveness of new interventions. The current format of cost-effectiveness analysis, however, does not allow for inclusion of more holistic aspects of health and, therefore, value elements for new technologies such as the impact on patients and society beyond its pure clinical and economic value. This study aimed to review the recent modelling attempts to expand the traditional cost-effectiveness analysis approach by incorporating additional elements of value in health technology assessment. A pragmatic literature review was conducted for articles published between 2012 and 2022 reporting cost-effectiveness analysis including value aspects beyond the clinical and cost-effectiveness estimates; searches identified 13 articles that were eligible for inclusion. These expanded modelling approaches mainly focused on integrating the impact of societal values and health equity in cost-effectiveness analysis, both of which were championed as important aspects of health technology assessment that should be incorporated into future technology assessments. The reviewed cost-effectiveness analysis methods included modification of the current cost-effectiveness analysis methodology (distributional cost-effectiveness analysis, augmented cost-effectiveness analysis, extended cost-effectiveness analysis) or the use of multi-criteria decision analysis. Of these approaches, augmented cost-effectiveness analysis appears to have the most potential by expanding traditional aspects of value, as it uses techniques already familiar to health technology assessment agencies but also allows space for incorporation of qualitative aspects of a product’s value. This review showcases that methods to unravel additional value elements for technology assessment exist, therefore, patient access to promising technologies can be improved by moving the discussion from “if” to “how” additional value elements can inform decision-making.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reconstructing the value puzzle in health technology assessment: a pragmatic review to determine which modelling methods can account for additional value elements

Muir¹,

Radhakrishnan²,

Freitag³

et al. 2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The importance of measuring health inequalities and contextualizing health outcomes across different patient groups has been widely acknowledged in recent years as evidenced by the prominence of health equality considerations among the SDGs as well as the Rio Political Declaration on Social Determinants of Health [ 1 , 2 ] and recent guidance by local HTA agencies (e.g., National Institute for Health and Care Excellence, Canadian Agency for Drugs and Technologies in Health). While providing accessible healthcare for all has been a key aim for most healthcare systems worldwide, there is evidence to suggest that specific, often marginalized, populations consistently experience poorer health outcomes due to a variety of socioeconomic and demographic differences [ 32 – 34 ]. A key aspect of the Rio Declaration was the commitment to develop robust data monitoring systems around health outcomes in order to unravel related inequalities [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Opportunity and accessibility: an environmental scan of publicly available data repositories to address disparities in healthcare decision-making

Vinals,

Radhakrishnan,

Sarri

2024

Int J Equity Health

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Background Health disparities, starkly exposed and exacerbated by coronavirus disease 2019, pose a significant challenge to healthcare system access and health outcomes. Integrating health inequalities into health technology assessment calls for robust analytical methodologies utilizing disaggregated data to investigate and quantify the scope of these disparities. However, a comprehensive summary of population datasets that can be used for this purpose is lacking. The objective of this review was to identify publicly accessible health inequalities data repositories that are potential resources for healthcare decision-making and future health technology assessment submissions. Methods An environmental scan was conducted in June of 2023 of six international organizations (World Health Organization, Organisation for Economic Co-operation and Development, Eurostat, United Nations Inter-agency Group for Child Mortality Estimation, the United Nations Sustainable Development Goals, and World Bank) and 38 Organisation for Economic Co-operation and Development countries. The official websites of 42 jurisdictions, excluding non-English websites and those lacking English translations, were reviewed. Screening and data extraction were performed by two reviewers for each data repository, including health indicators, determinants of health, and health inequality metrics. The results were narratively synthesized. Results The search identified only a limited number of country-level health inequalities data repositories. The World Health Organization Health Inequality Data Repository emerged as the most comprehensive source of health inequality data. Some country-level data repositories, such as Canada’s Health Inequality Data Tool and England’s Health Inequality Dashboard, offered rich local insights into determinants of health and numerous health status indicators, including mortality. Data repositories predominantly focused on determinants of health such as age, sex, social deprivation, and geography. Conclusion Interactive interfaces featuring data exploration and visualization options across diverse patient populations can serve as valuable tools to address health disparities. The data they provide may help inform complex analytical methodologies that integrate health inequality considerations into healthcare decision-making. This may include assessing the feasibility of transporting health inequality data across borders.

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“…However, it is well understood that the ultimate decision can be affected by an array of factors ( Figure 1 ). 13 …”

Section: Real-world Evidencementioning

confidence: 99%

What to Expect in 2024: Important Health Economics and Outcomes Research (HEOR) Trends

Abraham,

Hiligsmann,

Lee

et al. 2023

CEOR

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Can Real-World Evidence Help Restore Decades of Health Inequalities by Informing Health Care Decision-Making? Certainly, and Here is How

Cited by 7 publications

References 32 publications

Reconstructing the value puzzle in health technology assessment: a pragmatic review to determine which modelling methods can account for additional value elements

Reconstructing the value puzzle in health technology assessment: a pragmatic review to determine which modelling methods can account for additional value elements

Opportunity and accessibility: an environmental scan of publicly available data repositories to address disparities in healthcare decision-making

What to Expect in 2024: Important Health Economics and Outcomes Research (HEOR) Trends

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