Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Meng, Xiangming; Zhu, Kangxu; Wang, Jing; Liu, Pan

doi:10.1016/j.amjoto.2022.103523

Cited by 16 publications

(15 citation statements)

References 46 publications

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“…Similar to our ndings, most studies published during the covid-19 pandemic do not support strong evidence of auditory system insult due to intrauterine infection by the SARS-CoV-2 virus mirrored on normal newborn hearing screening tests [14,[37][38][39][40][41]. However, other studies are showing a possible negative impact on hearing of newborns of mothers infected by covid-19 during pregnancy [15,16].…”

Section: Discussionsupporting

confidence: 65%

Hearing Screening Test in neonates born to COVID-19-positive mothers

Goulioumis

Angelopoulou

Mourtzouchos

et al. 2022

Preprint

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Purpose SARS-CoV-2, the responsible virus for the covid-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from covid-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss. Methods This is a retrospective study in a regional pediatric hospital. The medical records of newborns (n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study. Results For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested. Conclusions Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies.

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Section: Discussionsupporting

confidence: 65%

Hearing Screening Test in neonates born to COVID-19-positive mothers

Goulioumis

Angelopoulou

Mourtzouchos

et al. 2022

Preprint

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“…More recently, a systematic review has also found a potential link between maternal SARS-CoV-2 and hearing impairment, although this association remains controversial. 35 …”

Section: Discussionmentioning

confidence: 99%

“…More recently, a systematic review has also found a potential link between maternal SARS-CoV-2 and hearing impairment, although this association remains controversial. 35 We were unable to examine the impact by trimester of maternal SARS-CoV-2 infection due to a paucity of studies examining offspring of first or second trimester infection. Other viruses such as Zika virus are known to be harmful to the developing fetus when contracted in the first or second trimester, 36 so there is a reasonable suspicion that this could be true for SARS-CoV-2.…”

Section: Neonatal Outcomesmentioning

confidence: 99%

Neonatal outcomes and indirect consequences following maternal SARS-CoV-2 infection in pregnancy: a systematic review

et al. 2023

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ObjectivesTo identify the association between maternal SARS-CoV-2 infection in pregnancy and individual neonatal morbidities and outcomes, particularly longer-term outcomes such as neurodevelopment.DesignSystematic review of outcomes of neonates born to pregnant women diagnosed with a SARS-CoV-2 infection at any stage during pregnancy, including asymptomatic women.Data sourcesMEDLINE, Embase, Global Health, WHOLIS and LILACS databases, last searched on 28 July 2021.Eligibility criteriaCase–control and cohort studies published after 1 January 2020, including preprint articles were included. Study outcomes included neonatal mortality and morbidity, preterm birth, caesarean delivery, small for gestational age, admission to neonatal intensive care unit, level of respiratory support required, diagnosis of culture-positive sepsis, evidence of brain injury, necrotising enterocolitis, visual or hearing impairment, neurodevelopmental outcomes and feeding method. These were selected according to a core outcome set.Data extraction and synthesisData were extracted into Microsoft Excel by two researchers, with statistical analysis completed using IBM SPSS (Version 27). Risk of bias was assessed using a modified Newcastle-Ottawa Scale.ResultsThe search returned 3234 papers, from which 204 were included with a total of 45 646 infants born to mothers with SARS-CoV-2 infection during pregnancy across 36 countries. We found limited evidence of an increased risk of some neonatal morbidities, including respiratory disease. There was minimal evidence from low-income settings (1 study) and for neonatal outcomes following first trimester infection (17 studies). Neonatal mortality was very rare. Preterm birth, neonatal unit admission and small for gestational age status were more common in infants born following maternal SARS-CoV-2 infection in pregnancy in most larger studies.ConclusionsThere are limited data on neonatal morbidity and mortality following maternal SARS-CoV-2 infection, particularly from low-income countries and following early pregnancy infections. Large, representative studies addressing these outcomes are needed to understand the consequences for babies born to women with SARS-CoV-2.PROSPERO registration numberCRD42021249818.

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Section: Sars-cov-2 and Reproductive Systemmentioning

confidence: 99%

“…It may relate to intrauterine infection, intrauterine hypoxia, and vertical transmission. Even though the newborn is not an organ of the mother, the newborn and the mother are an integral unit [ 187 ]. It has been reported that many factors contribute to ovary dysfunction during and after recovery from COVID-19 (immediate virus offensive, extreme immune response, and hypothalamus–pituitary–ovary axis dysfunction) [ 186 , 188 ].…”

Section: Sars-cov-2 and Reproductive Systemmentioning

confidence: 99%

SARS‐CoV‐2 infection and multi-organ system damage: a review

Rabaan

Smajlović

Tombuloğlu

et al. 2022

Bosn J of Basic Med Sci

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The BJBMS publishes an "Advanced online" manuscript format as a free service to authors in order to expedite the dissemination of scientific findings to the research community as soon as possible after acceptance following peer review and corresponding modification (where appropriate). An "Advanced online" manuscript is published online prior to copyediting, formatting for publication and author proofing, but is nonetheless fully citable through its Digital Object Identifier (doi®). Nevertheless, this "Advanced online" version is NOT the final version of the manuscript.

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Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

Cited by 16 publications

References 46 publications

Hearing Screening Test in neonates born to COVID-19-positive mothers

Hearing Screening Test in neonates born to COVID-19-positive mothers

Neonatal outcomes and indirect consequences following maternal SARS-CoV-2 infection in pregnancy: a systematic review

SARS‐CoV‐2 infection and multi-organ system damage: a review

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