Can schistosomiasis be defeated? An example from Senegal

Ndao, Babacar; Sy, Ibrahima; Talla, I.; Barbier, Dominique; Klotz, F.; Georges, P

doi:10.1684/mst.2013.0212

Cited by 1 publication

(2 citation statements)

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“…The village is situated near tributaries of the Tiokaye River, itself a tributary of the Gambia River. Assoni was enrolled as pilot village in the national control program of Senegal, namely ‘le Programme National de Lutte contre les bilharzioses’ (PNLB) [ 41 ]. The prevalence of S .…”

Section: Methodsmentioning

confidence: 99%

“…before treatment), but decreased to 50% in 2013 after three treatment rounds (2008, 2010, 2012) with praziquantel to those children that were diagnosed positively for S . mansoni infection [ 41 ]. Similar to above, eggs from positive stool samples were isolated after filtration, hatched and miracidia were individually pipetted onto Whatman FTA indicator cards in a volume of 3 μl of water [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

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Reconstructing Colonization Dynamics of the Human Parasite Schistosoma mansoni following Anthropogenic Environmental Changes in Northwest Senegal

et al. 2015

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BackgroundAnthropogenic environmental changes may lead to ecosystem destabilization and the unintentional colonization of new habitats by parasite populations. A remarkable example is the outbreak of intestinal schistosomiasis in Northwest Senegal following the construction of two dams in the ‘80s. While many studies have investigated the epidemiological, immunological and geographical patterns of Schistosoma mansoni infections in this region, little is known about its colonization history.Methodology/Principal FindingsParasites were collected at several time points after the disease outbreak and genotyped using a 420 bp fragment of the mitochondrial cytochrome c oxidase subunit 1 gene (cox1) and nine nuclear DNA microsatellite markers. Phylogeographic and population genetic analyses revealed the presence of (i) many genetically different haplotypes at the non-recombining mitochondrial marker and (ii) one homogenous S. mansoni genetic group at the recombining microsatellite markers. These results suggest that the S. mansoni population in Northwest Senegal was triggered by intraspecific hybridization (i.e. admixture) between parasites that were introduced from different regions. This would comply with the extensive immigration of infected seasonal agricultural workers from neighboring regions in Senegal, Mauritania and Mali. The spatial and temporal stability of the established S. mansoni population suggests a swift local adaptation of the parasite to the local intermediate snail host Biomphalaria pfeifferi at the onset of the epidemic.Conclusions/SignificanceOur results show that S. mansoni parasites are very successful in colonizing new areas without significant loss of genetic diversity. Maintaining high levels of diversity guarantees the adaptive potential of these parasites to cope with selective pressures such as drug treatment, which might complicate efforts to control the disease.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%