Can sex influence the neurocognition of language? Evidence from Parkinson's disease

Reifegerste, Jana; Estabrooke, Ivy V.; Russell, Lauren E.; Veríssimo, João; Johari, Karim; Wilmarth, Barbara; Pagán, Fernando; Moussa, Charbel; Ullman, Michael T.

doi:10.1016/j.neuropsychologia.2020.107633

Cited by 7 publications

(14 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, female PD patients should compensate more effectively with declarative memory than male PD patients, including for regular inflection (see Discussion). Thus, male PD patients should tend to have greater impairments at regular inflection than female PD patients (Reifegerste, Estabrooke, Maloof, Johari, & Ullman, 2018; Ullman et al, 2008; Ullman & Pullman, 2015). In particular, this sex difference should be found for (reasonably common) existing regularly inflected forms (e.g., walked), because they are likely to have been previously encountered, and therefore could have been memorized as chunks, but not for regularly inflected forms of novel verbs (e.g., plag - plagged ), because these could not have been previously memorized.…”

Section: The Declarative/procedural Model and Its Predictions For Par...mentioning

confidence: 99%

“…We are aware of nine studies that have examined regular/irregular inflectional morphology in PD patients and healthy controls. Four of these tested the distinction in English (Almor et al, 2002; Longworth et al, 2005; Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997), whereas the others probed Dutch (Colman et al, 2009), German (Penke & Wimmer, 2012), French (Macoir et al, 2013), and Greek (Stavrakaki, Katsarou, Bostantzopoulou, & Clahsen, 2010; Terzi et al, 2005). Note that a 10th study (Phillips et al, 2012) investigated the effects of deep brain stimulation on regular/irregular English past-tense production, but did not directly compare regulars and irregulars either within PD patients or between patients and controls.…”

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

“…In brief, the data thus far suggest the following, though with clear gaps and weaknesses. Only at more advanced stages of PD disease progression do deficits of regular inflection seem to be reliable (Almor et al, 2002; Colman et al, 2009; Longworth et al, 2005; Macoir et al, 2013; Penke & Wimmer, 2012; Reifegerste, Estabrooke, et al, 2018; Stavrakaki et al, 2010; Terzi et al, 2005; Ullman et al, 1997). Limited evidence suggests that sex may also moderate the regular deficit, with particular impairments in males at more advanced stages (Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997).…”

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

“…Only at more advanced stages of PD disease progression do deficits of regular inflection seem to be reliable (Almor et al, 2002; Colman et al, 2009; Longworth et al, 2005; Macoir et al, 2013; Penke & Wimmer, 2012; Reifegerste, Estabrooke, et al, 2018; Stavrakaki et al, 2010; Terzi et al, 2005; Ullman et al, 1997). Limited evidence suggests that sex may also moderate the regular deficit, with particular impairments in males at more advanced stages (Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997). The data also appear to be consistent with the prediction that left basal ganglia degeneration, as reflected in right-side hypokinesia, moderates regular but not irregular inflection (Longworth et al, 2005; Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997).…”

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

“…Limited evidence suggests that sex may also moderate the regular deficit, with particular impairments in males at more advanced stages (Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997). The data also appear to be consistent with the prediction that left basal ganglia degeneration, as reflected in right-side hypokinesia, moderates regular but not irregular inflection (Longworth et al, 2005; Reifegerste, Estabrooke, et al, 2018; Ullman et al, 1997). We are not aware of any research investigating the relation between regular/irregular inflection and dopaminergic processes.…”

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

See 4 more Smart Citations

Sex, dopamine, and hypokinesia: A study of inflectional morphology in Parkinson’s disease.

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective: Parkinson’s disease (PD), which involves the degeneration of dopaminergic basal ganglia neurons, appears to affect language. We investigated which aspects of language are impaired in PD and what moderates these impairments. Our predictions were based on the declarative/procedural model of language, which links grammar, including in regular inflection, to procedural memory and left-lateralized basal ganglia dopaminergic circuits but links lexical memory, including irregulars, to declarative memory. Because females tend to show declarative memory advantages as compared to males, the model predicts that females rely more on this system for regulars, which can be stored as chunks. Method: We probed regular/irregular Farsi past-tense production in 40 Farsi-speaking patients with moderate-to-severe nondemented PD (half female) and 40 normal controls (half female). Results: Consistent with our predictions, we found that male, but not female, PD patients showed greater deficits at regular than irregular past-tense production. The females’ impairment was mildest for regulars, likely from compensatory storage, as revealed by regular past-tense frequency effects only in females. Right-side hypokinesia (linked to left basal ganglia degeneration) correlated negatively with accuracy of regulars but not irregulars. Similarly, the levodopa equivalent dose of patients’ last medication correlated only with regulars. Conclusions: The results suggest that language is impaired in PD, but the impairments are moderated by multiple factors, including the type of linguistic knowledge, the degree of left basal ganglia degeneration, dopamine, and sex. The findings underscore the impact of sex on the neurocognition of language and the roles of left basal ganglia dopaminergic circuits in aspects of rule-governed grammar.

show abstract

Section: The Declarative/procedural Model and Its Predictions For Par...mentioning

confidence: 99%

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

Section: Previous Research On Regular/irregular Morphology In Pdmentioning

confidence: 99%

See 3 more Smart Citations

Sex, dopamine, and hypokinesia: A study of inflectional morphology in Parkinson’s disease.

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson’s Disease, and Huntington’s Disease

et al. 2022

View full text Add to dashboard Cite

Clinical populations with basal ganglia pathologies may present with language production impairments, which are often described in combination with comprehension measures or attributed to motor, memory, or processing-speed problems. In this systematic review and meta-analysis, we studied word production in four (vascular and non-vascular) pathologies of the basal ganglia: stroke affecting the basal ganglia, small vessel disease, Parkinson's disease, and Huntington's disease. We compared scores of these clinical populations with those of matched cognitively unimpaired adults on four well-established production tasks, namely picture naming, category fluency, letter fluency, and past-tense verb inflection. We conducted a systematic search in PubMed and PsycINFO with terms for basal ganglia structures, basal ganglia disorders and language production tasks. A total of 114 studies were included, containing results for one or more of the tasks of interest. For each pathology and task combination, effect sizes (Hedges' g) were extracted comparing patient versus control groups. For all four populations, performance was consistently worse than that of cognitively unimpaired adults across the four language production tasks (p-values < 0.010). Given that performance in picture naming and verb inflection across all pathologies was quantified in terms of accuracy, our results suggest that production impairments cannot be fully explained by motor or processing-speed deficits. Our review shows that while language production difficulties in these clinical populations are not negligible, more evidence is necessary to determine the exact mechanism that leads to these deficits and whether this mechanism is the same across different pathologies.

show abstract

Hijacking limitations of working memory load to test for composition in language

Ullman,

Bulut,

Walenski

2024

Cognition

View full text Add to dashboard Cite

Can sex influence the neurocognition of language? Evidence from Parkinson's disease

Cited by 7 publications

References 85 publications

Sex, dopamine, and hypokinesia: A study of inflectional morphology in Parkinson’s disease.

Sex, dopamine, and hypokinesia: A study of inflectional morphology in Parkinson’s disease.

Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson’s Disease, and Huntington’s Disease

Hijacking limitations of working memory load to test for composition in language

Contact Info

Product

Resources

About