Can single pulse electrical stimulation provoke responses similar to spontaneous interictal epileptiform discharges?

Dynamic changes of interictal post-spike slow waves toward seizure onset in focal cortical dysplasia type II

“…Also, according to findings from recent study by Nayak et al (2014), the slow waves induced by electrical stimulation may have similar implication as the slow waves of spontaneous spike-wave discharges, which correspond to PSS in this study. Such evidence is congruent with our findings that high power PSS was confined to SOZ during the preictal period.…”

High-frequency oscillations are under your control. Don’t chase all of them

“…The team found that single-pulse stimulation evoked delayed fast ripples consistently across patients with and without spontaneous fast ripples, and that delayed fast ripples predicted the seizure onset zone with accuracy equivalent to that of spontaneous fast ripples. The current study, together with previous work (Valentín et al, 2005; Alarcón et al, 2012; Nayak et al, 2014), provided evidence that single-pulse stimulation paradigms can quantify the diverse profiles of HFOs in a rapid and controlled manner and can play a role in directing the surgical decision.…”

Electrical Stimulation of the Anterior Cingulate Gyrus Induces Responses Similar to K-complexes in Awake Humans

“…In our series, seizure onset in 4 out of 6 patients did not involve medial frontal cortex, suggesting that our observations are not necessarily due to abnormalities in cingulate cortex. Responses to SPES and spontaneous epileptiform discharges show similar characteristics in terms of cellular behavior [25], EEG morphology [42,43] and cognitive effects [44]. Both appear to share similar generic physiological mechanisms and spontaneous interictal epileptiform discharges could be considered as triggered by some form of endogenous stimulation or synchronization.…”