2020
DOI: 10.2147/ccid.s271760
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Can Sodium Thiosulfate Act as a Reversal Agent for Calcium Hydroxylapatite Filler? Results of a Preclinical Study

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Cited by 14 publications
(18 citation statements)
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“…One study tested topical NTG ointment, and the other four studies tested sodium thiosulfate (STS). The STS study by Robinson [39] additionally investigated the effects of topical sodium metabisulfite (SMB) in combination and in isolation from intralesional STS. Topical SMB was not found to be helpful in CaHA-associated complications.…”
Section: Resultsmentioning
confidence: 99%
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“…One study tested topical NTG ointment, and the other four studies tested sodium thiosulfate (STS). The STS study by Robinson [39] additionally investigated the effects of topical sodium metabisulfite (SMB) in combination and in isolation from intralesional STS. Topical SMB was not found to be helpful in CaHA-associated complications.…”
Section: Resultsmentioning
confidence: 99%
“…Results were varied in the four STS studies. One found complete dissolution of CaHA with STS [39] , one found partial reduction [38] , and the remaining two found no evidence indicating STS could dissolve CaHA [40,41] . Of note, the two studies that found no evidence supporting STS were the most recently published in 2020 and 2021, respectively [40,41] .…”
Section: Resultsmentioning
confidence: 99%
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“…Alguns autores estudam um agente de reversão para os casos de redução de nódulo, desvio de material, redução de volume de sobrecorreção e oclusão vascular.. Rullan, et al, (2019) relataram dois casos clínicos de nódulos visíveis de hidroxiapatita de cálcio, cujo tratamento com o tiossulfeto de sódio foi bemsucedido. Entretanto, Danysz, et al, (2020) em seu estudo pré-clinico, concluíram que apesar do tiossulfeto de sódio ter apresentado uma eficácia maior que a solução salina, o uso da solução salina ainda é mais seguro pois o uso do tiossulfeto de sódio apresentou risco de necrose tecidual e hemorragia. Além disso, o mecanismo de ação do tiossulfeto de sódio sugere ser de dispersão e não de degradação, desta forma não ajudaria nos casos de oclusão vascular.…”
Section: Discussionunclassified