Can suicide behavior and seasonality of suicide be predicted from inflammatory parameters in adolescents?

Ucuz, İ̇̇lknur; Tetik, Burcu Kayhan

doi:10.1016/j.mehy.2020.110061

Cited by 19 publications

(24 citation statements)

References 23 publications

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“…As a whole, to our knowledge, few articles investigated the potential role of NLR in suicidal behavior and these studies present different methods and samples than our research. 25,44 Nevertheless, even though most studies reported higher levels of NLR in suicide attempters than individuals without suicidal behavior, these results can be discordant respect to our findings for the following reasons. First of all, the severity of depression and suicide may be related to distinct immune-biological profiles in peripheral blood.…”

Section: Main Findingscontrasting

confidence: 70%

“…However, it appears to be difficult to compare our results with those reported by Orum 26 and Kara 27 since they excluded patients with a history of psychiatric treatments and with current psychiatric disorders, apart from those with major depression or anxiety, whilst we included a sample of patients affected by psychiatric disorders requiring hospitalization. As a whole, to our knowledge, few articles investigated the potential role of NLR in suicidal behavior and these studies present different methods and samples than our research 25,44 . Nevertheless, even though most studies reported higher levels of NLR in suicide attempters than individuals without suicidal behavior, these results can be discordant respect to our findings for the following reasons.…”

Section: Main Findingsmentioning

confidence: 86%

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Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

et al. 2020

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Background Suicidality is one of the most common complications of mental disorders, so that the identification of potential biomarkers may be relevant in clinical practice. To date, the role of serum lipids and neutrophil/lymphocyte ratio (NLR) has been explored albeit with conflicting results. To the best of our knowledge, no study has explored lipid levels concomitantly with NLR in relation to violent suicide attempts. Therefore, we aimed to investigate whether serum lipid levels and NLR might be associated with the violent method of suicide attempts. Methods The study group consisted of 163 inpatients who attempted suicide. Blood samples were collected at the beginning of hospitalization to measure total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, very-low-density lipoprotein (VLDL), triglycerides, and NLR. Descriptive analyses of the total sample were performed. The included patients were divided into two groups according to violent/nonviolent method. Groups were compared in terms of lipid (MANCOVAs). Results Plasma levels of total cholesterol (F = 5.66; P = .02), LDL (F = 4.94; P = .03), VLDL (F = 5.66; P = .02), and NLR (F = 8.17; P < .01) resulted to be significantly lower in patients that used a violent method compared to patients who attempted suicide with a nonviolent method. Conclusions Low cholesterol, LDL, and VLDL levels as well as low NLR value were associated with a violent method of suicide attempt in patients with mental disorders. Further studies are needed to confirm these results.

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Section: Main Findingscontrasting

confidence: 70%

Section: Main Findingsmentioning

confidence: 86%

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

et al. 2020

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“…These findings coincided with the idea of “Cytokines as Suicide Risk Biomarkers” ( Pandey, 2015 ). Recently, hemogram parameters like neutrophil/lymphocyte and monocyte/lymphocyte ratios were also reported predicting adolescent suicide ( Ucuz and Kayhan Tetik, 2020 ).…”

Section: A Flame In the Dark: Inflammatory Biomarkers For Predicting Suicidementioning

confidence: 99%

Life in the flame: Inflammation sounds the alarm for suicide risk

Yan

Jiang

2021

Brain, Behavior, & Immunity - Health

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As suicide became a critical issue in mental healthcare, the World Health Organization (WHO) presented a Mental Health Action Plan in 2013. Particularly, the plan set an explicit goal for suicide prevention, which called for 10% reduction in the suicide rate in member countries by 2020. Now the tough year of 2020 has passed by, many valuable breakthroughs on suicide research have emerged during these recent years. To some extent, a multi-stage system for the prediction and prevention of suicide is taking shape. Inflammatory biomarkers may have a promising future within this field.

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“…The innate immune cells, mainly consisting of macrophages, monocytes, granulocytes, dendritic cells, and Natural Killer (NK) cells provide the first-line of defense by recognizing and responding to pathogenic and other danger signals. The pathogen-specific B cells that produce antibodies and T cells, including the helper, memory, cytotoxic and regulatory T cell subsets, mediate the acquired immune response and these cells are found altered in depression and suicidal behavior ( Ucuz and Kayhan Tetik, 2020 ; Martinez-Botia et al., 2020 ). The immune response is orchestrated in a tightly-regulated fashion by engaging innate and adaptive components and is dependent on the pro and anti-inflammatory messenger molecules, the cytokines, produced in the CNS and the periphery.…”

Section: Neuroimmune Dysregulation In Suicide Suicidal Behavior and Associated Conditionsmentioning

confidence: 99%

Psychoneuroimmunology: The new frontier in suicide research

Neupane

2021

Brain, Behavior, & Immunity - Health

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Elucidating complex, multifactorial phenomena like suicide and suicidal behaviors (SSB) require multidisciplinary fields such as Psychoneuroimmunology (PNI). Indeed, our appreciation of the bidirectional communication channels between the brain and the rest of the body with its immune arsenal as the key player has positioned PNI as a promising field of research. We now know that major psychiatric, behavioral, and somatic disorders related to SSB accompany neuroimmune dysregulation. These disorders range from depression, emotional dysregulation, atopy, and epilepsy to certain viral and parasitic infections. By utilizing epidemiological, genetic, microbial, and molecular approaches, the PNI research community has excogitated novel biomarker candidates and pathways in support of SSB risk stratification at individual level. This remarkable progress in just two previous decades shall, if successful, help implement personalized prevention and treatment strategies, using PNI-assisted tools. The aims of this narrative review and opinion piece are to summarize important discoveries concerning the role of neuroimmune activation in SSB and to highlight important future directions for the field. Major caveats of the findings concerning methodological approaches, clinical reality of frequent comorbid psychopathology, and novel molecular targets are presented. Finally, this review calls on the PNI research community for increased attention towards factors that promote resilience to suicide, while accepting “consciousness” under its wing. Thus, PNI represents the new frontier in suicide research. Future breakthroughs in this discipline shall bring us closer to understanding the biological substrates of qualia i.e., subjective, and experiential meanings of life and death.

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Can suicide behavior and seasonality of suicide be predicted from inflammatory parameters in adolescents?

Cited by 19 publications

References 23 publications

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

Life in the flame: Inflammation sounds the alarm for suicide risk

Psychoneuroimmunology: The new frontier in suicide research

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