Can the adverse effects of antiepileptic drugs be detected in saccadic eye movements?

Park, Kang Min; Shin, Kyoungsoon; Ha, Sam Yeol; Park, Jinse; Kim, Si Eun; Kim, Hyung Chan; Lee, Joon Won; Kim, Sung Eun

doi:10.1016/j.seizure.2014.12.003

Cited by 6 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of drugs on EM have been studied for a long time (Wise, 1984 ). One reason for this is they inform us about drug effects on the central nervous system (Park et al, 2015 ). Psychotropic drugs can alter the basic EM but also have an impact on oculomotor performances in emotional information processing (Sweeney et al, 1994 ; Reilly et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature

et al. 2015

View full text Add to dashboard Cite

Background: The analysis of eye movements (EM) by eye-tracking has been carried out for several decades to investigate mood regulation, emotional information processing, and psychomotor disturbances in depressive disorders.Method: A systematic review of all English language PubMed articles using the terms “saccadic eye movements” OR “eye-tracking” AND “depression” OR “bipolar disorders” was conducted using PRISMA guidelines. The aim of this review was to characterize the specific alterations of EM in unipolar and bipolar depression.Results: Findings regarding psychomotor disturbance showed an increase in reaction time in prosaccade and antisaccade tasks in both unipolar and bipolar disorders. In both disorders, patients have been reported to have an attraction for negative emotions, especially for negative pictures in unipolar and threatening images in bipolar disorder. However, the pattern could change with aging, elderly unipolar patients disengaging key features of sad and neutral stimuli. Methodological limitations generally include small sample sizes with mixed unipolar and bipolar depressed patients.Conclusion: Eye movement analysis can be used to discriminate patients with depressive disorders from controls, as well as patients with bipolar disorder from patients with unipolar depression. General knowledge concerning psychomotor alterations and affective regulation strategies associated with each disorder can also be gained thanks to the analysis. Future directions for research on eye movement and depression are proposed in this review.

show abstract

Section: Discussionmentioning

confidence: 99%

Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Participants with corrected vision were asked to remove their glasses and wear COMO SPORT L glasses with lenses adjusted to their visual acuity for the duration of the experiment. Participants were excluded from the study if they had a history of seizures, traumatic brain injury, psychiatric or neurodevelopmental conditions other than autism (not including ADHD or anxiety), or if they were taking any antiepileptic or anticonvulsant medication, as these can impact eye movements (Aschoff, 1968;Cohen et al, 1985;Tedeschi et al, 1989;Remler et al, 1990;Zaccara et al, 1992;Goldman and Schultz-Ross, 1993;Hilton et al, 2004;Lo et al, 2008;Reilly et al, 2008;Park et al, 2015;Lunn et al, 2016). The current study was approved by the Institutional Review Boards (IRB) of the University of Rochester Medical Center and of the Albert Einstein College of Medicine.…”

Section: Participants and Phenotypic Assessmentsmentioning

confidence: 99%

No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis

Tarrit,

Freedman,

Francisco

et al. 2023

Front. Integr. Neurosci.

View full text Add to dashboard Cite

BackgroundAltered patterns of eye-movements during scene exploration, and atypical gaze preferences in social settings, have long been noted as features of the Autism phenotype. While these are typically attributed to differences in social engagement and interests (e.g., preferences for inanimate objects over face stimuli), there are also reports of differential saccade measures to non-social stimuli, raising the possibility that fundamental differences in visuo-sensorimotor processing may be at play. Here, we tested the plasticity of the eye-movement system using a classic saccade-adaptation paradigm to assess whether individuals with ASD make typical adjustments to their eye-movements in response to experimentally introduced errors. Saccade adaptation can be measured in infants as young as 10 months, raising the possibility that such measures could be useful as early neuro-markers of ASD risk.MethodsSaccade amplitudes were measured while children and adults with ASD (N = 41) and age-matched typically developing (TD) individuals (N = 68) made rapid eye-movements to peripherally presented targets. During adaptation trials, the target was relocated from 20-degrees to 15-degrees from fixation once a saccade to the original target location was initiated, a manipulation that leads to systematic reduction in saccade amplitudes in typical observers.ResultsNeither children nor adults with ASD showed any differences relative to TD peers in their abilities to appropriately adapt saccades in the face of persistently introduced errors.ConclusionOf the three studies to date of saccade adaptation in ASD, none have shown deficits in saccade adaptation that are sufficient to generalize to the whole or a subgroup of the ASD population. Unlike prior studies, we found no evidence for a slower adaptation rate during the early adaptation phase, and no of evidence greater variance of saccade amplitudes in ASD. In post hoc analysis, there was evidence for larger primary saccades to non-adapted targets, a finding requiring replication in future work.

show abstract

“…10 The movements of the left eye were recorded using a high-resolution infrared scleral reflectance technique (resolution 320 × 240 pixels, sampling rate 60 Hz, SLVNG; SLMED Inc., Seoul, Korea). The visual stimulus was a white square target on a dark-blue background.…”

Section: Video-oculographymentioning

confidence: 99%

“…9 Additionally, we recently demonstrated that saccadic eye movements using video-oculography (VOG) can be screened to identify patients with a high risk of adverse reactions to AEDs. 10 However, no study has investigated whether eye movements could reflect the efficacy of AEDs in patients with epilepsy. The aim of this study was to determine whether the efficacy of AEDs could be assessed with eye movements using VOG.…”

Section: Introductionmentioning

confidence: 99%

Can pursuit eye movements reflect the efficacy of antiepileptic drugs?

Kim

Park

2017

Ann Clin Neurophysiol

Self Cite

View full text Add to dashboard Cite

Background:We evaluated whether eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy. Methods: Thirty patients with epilepsy of unknown cause as well as age-and sex-matched normal controls were enrolled in this study. We divided the patients into drug-controlled epilepsy (n = 22) and drug-resistant epilepsy (n = 8) groups according to their seizure controls. We analyzed the differences in the parameters of the eye movements in these two groups compared with normal controls using video-based electro-oculography. In addition, we investigated the differences in the cerebellar volumes of these two groups using whole-brain T1-weighted images. Results: The latency and accuracy of saccade in patients with epilepsy were significantly different from normal controls, but they were not different between patients with drug-controlled epilepsy and drug-resistant epilepsy. However, the gain of pursuit was significantly decreased in patients with drug-resistant epilepsy compared with normal controls (p = 0.0010), whereas it was not different between patients with drug-controlled epilepsy and normal controls (p = 0.9646). In addition, the patients with drug-resistant epilepsy had lower cerebellar volumes than normal controls (p = 0.0052), whereas the cerebellar volumes in patients with drug-controlled epilepsy were not different from normal controls (p = 0.5050). Conclusions: We demonstrated that pursuit eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy, a finding that may be related to cerebellar dysfunction.

show abstract

Can the adverse effects of antiepileptic drugs be detected in saccadic eye movements?

Abstract: The total latency and accuracy of video-based electro-oculography may be screened to identify patients with a high risk of adverse effects with antiepileptic-drugs.

Cited by 6 publications

References 23 publications

Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature

Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature

No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis

Can pursuit eye movements reflect the efficacy of antiepileptic drugs?

Contact Info

Product

Resources

About