Can the aqueous decoction of mango flowers be used as an antiulcer agent?

Lima, Zeila Pinheiro; Severi, Juliana Aparecida; Pellizzon, Cláudia Helena; Brito, Arms; Solís, Pablo N.; Cáceres, Armando; Girón, Lidia M.; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2005.11.032

Cited by 71 publications

(51 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Entre as diversas doenças de grande incidência entre a população, as úlceras gástricas e duodenais representam uma das mais importantes, pois afetam um número considerável de pessoas em todo o mundo, sendo citadas, por alguns autores, como "a nova praga do século 21" (Hiruma- Lima et al, 2006).…”

Section: Resultsunclassified

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Donatini¹,

Ishikawa²,

Barros³

et al. 2009

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO:Syzygium jambos (L.) Alston, Myrtaceae, é empregado na medicina popular como digestivo e antiinflamatório. A triagem fitoquímica da droga pulverizada (folhas) indicou a presença de flavonóides, taninos e óleo volátil. O extrato hidroetanólico a 70% das folhas de S. jambos foi preparado por percolação e liofilizado. O conteúdo de taninos das folhas e do extrato foi calculado, respectivamente, em 21,9% e 43,3%. O teor de flavonóides foi de 0,6% (folhas) e 1,2% (extrato). A administração oral prévia do extrato (400 mg/kg) a ratos Wistar reduziu significativamente as lesões gástricas induzidas por etanol acidificado. No modelo de úlcera subcrônica, com indução de lesão gástrica utilizando ácido acético a 30%, o tratamento com o extrato (400 mg/kg) não apresentou resultado significativo. A atividade antioxidante do extrato foi avaliada através dos modelos de lipoperoxidação e de medida de capacidade seqüestrante de radicais DPPH. Os valores obtidos de Q 1/2 (MDA) e CE 50 (DPPH) foram, respectivamente, 0,17 mg/mL e 5,68 mg/mL.Unitermos: Syzygium jambos, Myrtaceae, atividade antiúlcera, atividade antioxidante.ABSTRACT: "Antiulcerogenic and antioxidant activities of leaf extract of Syzygium jambos (L.) Alston (Myrtaceae)". Syzygium jambos (L.) Alston, Myrtaceae, is commonly employed in folk medicine as digestive and anti-inflammatory. Phytochemical screening of the powdered dried leaves indicates the presence of flavonoids, tannins and essential oil. Hydroethanol extracts (70%) were prepared by percolation and freeze-drying. The tannin content of dried leaves and extract was, respectively, 21.9% and 43.3%. The flavonoid content was 0.6% (dried leaves) and 1.2% (extract). Previous oral administration of S. jambos leaves extract (400 mg/kg) to rats reduced significantly gastric injury induced by HCl/ethanol. At the subcronic ulcer model by induction with 30% acetic acid the results were not significant. In vitro antioxidant activity of S. jambos extract was evaluated by malondialdehyde (MDA) and DPPH free radical method. The Q 1/2 for MDA assay was 0.17 mg/mL and the EC 50 for DPPH assay was 5.68 mg/mL.

show abstract

Section: Resultsunclassified

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Donatini¹,

Ishikawa²,

Barros³

et al. 2009

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Rich (Z. abyssinica) which has been used by herbalists in northern Nigeria for the treatment of ulcer [4]. The antibacterial, antioxidant and phytochemical screening of the fruit extracts of this plant have been reported [5].…”

Section: Introductionmentioning

confidence: 99%

Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

Yau

Abdulazeez

Anigo

et al. 2017

JAD

View full text Add to dashboard Cite

“…The pathophysiology of peptic ulcer has been centralized on an imbalance between aggressive and protective factors in the stomach such as acid-pepsin secretion, mucosal barrier, mucus secretion, blood flow, cellular regeneration, prostaglandins and epidermal factors (Lima et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats

Massignani

Lemos

Maistro

et al. 2009

Phytotherapy Research

View full text Add to dashboard Cite

Baccharis dracunculifolia DC (Asteraceae), a native plant from Brazil, commonly known as 'Alecrimdo-campo' is widely used in folk medicine to treat inflammation, hepatic disorders and stomach ulcers, and it is the most important botanical source of Southeastern Brazilian propolis, known as green propolis. Its essential oil is composed of non-oxygenated and oxygenated terpenes. In this work, the effects of the essential oil obtained from the aerial parts of B. dracunculifolia on gastric ulcers were evaluated. The antiulcer assays were undertaken using the following protocols in rats: nonsteroidal antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, stress-induced ulcer, and determination of gastric secretion using ligated pylorus. The treatment in the doses of 50, 250 and 500 mg/kg of B. dracunculifolia essential oil significantly diminished the lesion index, the total lesion area and the percentage of lesions in comparison with both positive and negative control groups. With regard to the model of gastric secretion a reduction of gastric juice volume and total acidity was observed, as well as an increase in the gastric pH. No sign of toxicity was observed in the acute toxicity study. Considering the results, it is suggested that the essential oil of B. dracunculifolia could probably be a good therapeutic agent for the development of new phytotherapeutic medicine for the treatment of gastric ulcer.

show abstract

Can the aqueous decoction of mango flowers be used as an antiulcer agent?

Cited by 71 publications

References 35 publications

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats

Contact Info

Product

Resources

About