Can the Behaviour Abnormalities Induced by Gestational Stress in Rats be Prevented or Reversed?

Weinstock, Marta

doi:10.1080/1025389021000010503

Cited by 37 publications

(38 citation statements)

References 99 publications

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“…Moreover, in studies of both humans and animals, many different types of prenatal stressors were found to have significant effects on postnatal behavior. Weinstock (2002), for example, noted that procedures used to induce stress in pregnant rats have included saline injections, physical restraint, exposure to loud noises, foot-shocks, overcrowding, and immersion in cold water. The effects of exposure to prenatal stress on postnatal behavior have also been produced by exposing pregnant monkeys and rodents to stress hormones such as glucocorticoids (GCs) (Matthews, 2000;Scheepens et al, 2003).…”

Section: Different Types Of Prenatal Stressors Can Affect Postnatal Dmentioning

confidence: 99%

Prenatal stress and risk for autism

Kinney

Münir

Crowley

et al. 2008

Neuroscience & Biobehavioral Reviews

373

251

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This paper reviews several converging lines of research that suggest that prenatal exposure to environmental stress may increase risk for Autistic Disorder (AD). We first discuss studies finding that prenatal exposure to stressful life events is associated with significantly increased risk of AD, as well as other disorders, such as schizophrenia and depression. We then review evidence from animal and human studies that prenatal stress can produce both (a) abnormal postnatal behaviors that resemble the defining symptoms of AD, and (b) other abnormalities that have elevated rates in AD, such as learning deficits, seizure disorders, perinatal complications, immunologic and neuroinflammatory anomalies, and low postnatal tolerance for stress. We explain why an etiologic role for prenatal stress is compatible with genetic factors in AD, and describe how stress can disrupt fetal brain development. Finally, we discuss implications for understanding underlying processes in AD, including potential gene-environment interactions, and developing new therapies and early prevention programs.

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Section: Different Types Of Prenatal Stressors Can Affect Postnatal Dmentioning

confidence: 99%

Prenatal stress and risk for autism

Kinney

Münir

Crowley

et al. 2008

Neuroscience & Biobehavioral Reviews

373

251

View full text Add to dashboard Cite

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“…Diversos trabalhos têm mostrado que os efeitos do estresse pré-natal sobre o funcionamento do eixo HPA são mais pronunciados após a exposição dos animais a um outro estresse na idade adulta (WEINSTOCK, 1997(WEINSTOCK, , 2001(WEINSTOCK, , 2002. Assim, como no presente experimento os níveis de estimulação ambiental eram pequenos ou mínimos no campo aberto, não induziram, provavelmente, qualquer alteração na atividade do eixo HPA, isto é`não representaram um estresse adicional.…”

Section: Resultsunclassified

“…Alterações do funcionamento do eixo HPA nos animais estressados já foram descritas por vários autores (TAKAHASHI; KALIN, 1991;TAKAHASHI et al, 1988;WEINSTOCK, 1997WEINSTOCK, , 2002WEINSTOCK, , 2005WEINSTOCK et al, 1992 …”

Section: Resultsunclassified

“…O estresse, via liberação de glicocorticóides, atua favorecendo as respostas do tipo Th2 (IWAKABE et al, 1998 (CABRERA et al, 1999;JONES;TAUSCHER, 1978;LOU et al, 1994;SECKL, 2001;WEINSTOCK, 2001) e alta incidência de distúrbios emocionais em crianças (WARD; STEHM, 1991). Foi descrita, também, a existência de uma associação entre o estresse pré-natal e a esquizofrenia, a depressão, o suicídio e abuso de drogas (BUITELAAR et al, 2003;KOENIG;KIRKPATRICK;LEE, 2002;KOFMAN, 2002;WATSON et al, 1999;WEINSTOCK, 2001WEINSTOCK, , 2002.…”

Section: Il4 Fator De Necrose Tumoral (Tnf) E Interferon Gama (Inf) unclassified

“…Estudos recentes mostraram em ratos e macacos que o estresse materno induz comportamentos ansiogênicos e depressivos, caracterizados por depressão comportamental, desamparo aprendido e anedonia (WEINSTOCK, 2001(WEINSTOCK, ,2002(WEINSTOCK, ,2005.…”

Section: Il4 Fator De Necrose Tumoral (Tnf) E Interferon Gama (Inf) unclassified

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Participação do sistema opioidérgico e dos glicocorticóides nas alterações comportamentais e da imunidade inata induzidas na prole pelo estresse pré-natal

Fonseca¹

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Participação do sistema opioidérgico e dos glicocorticóides nas alterações comportamentais e da imunidade inata induzidas na prole pelo estresse pré-natalDue to its rapid growth, the fetus is particularly vulnerable to insults and the attendant changes in its hormonal milieu. This led to the suggestion that adverse life situations experienced by the pregnant mother can induce alterations in the fetal environment and result in deleterious effects on the rate of development and health of the child. In view of the considerable methodological difficulties in assessing the impact of the stress on human mothers, and evaluating its effects on the development and behavior of their children, much of our information about sequelae from gestational stress has been derived from studies in experimental animals. That was the objective of this study, taking into account the required grounds for reasonable comparisons. We particularly aimed the effects of prenatal stress applied from gestational day (GD) 15 to GD19 on behavior, immunological parameters, levels of corticosterone and testosterone and brain neurochemistry of male and female Swiss mice offspring, on post natal day 30. We also study the effects of naloxone (opioid antagonist) and of metyrapone (corticosterone synthesis inhibitor), both applied before prenatal stress, on parameters described above. The results of this work showed that: 1) prenatal stress increased total locomotion in males evaluated in an open field and naloxone treatment before stress prevented this effect; 2) prenatal stress and metyrapone injection increased anxiety levels of male and female offspring. Metyrapone injection before prenatal stress prevented this effect; 3) naloxone, alone or associated to prenatal stress, decreased oxidative burst of blood neutrophils in male and female pups. On the other hand, in female offspring naloxone alone increased blood neutrophil phagocytosis; 4) prenatal stress decreased phagocytosis of peritoneal macrophage and naloxone before stress prevented this effect; 5) prenatal stress decreased oxidative burst and phagocytosis of peritoneal macrophage in female pups and naloxone treatment before stress prevented this effect; 6) prenatal stress decreased corticosterone serum levels in male offspring and naloxone treatment, alone or associated to stress increased it. 7) In female pups, prenatal stress increased corticosterone serum levels and metyrapone before stress prevented this alteration; 8) gestational stress increased Nor turnover in male and female offspring; 9) naloxone increased DA turnover only in male offspring; 10) metyrapone treatment increased DA turnover in male and female offspring; 11) prenatal stress, naloxone or metyrapone treatment had different effects on male and female offspring. Altogether, these findings show that prenatal stress has relevant effects on animal development; these effects last until adulthood. The results also show that many of prenatal stress effects can be prevented by naloxone or metyrapone, and suggests that the opioid sys...

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Transgenerational effects of infantile adversity and enrichment in male and female rats

Leshem

Schulkin

2011

Developmental Psychobiology

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To discover whether the accumulation of life's experiences, adverse and enriching, inform, and serve the following generation by inheritance we examine whether stress to a weanling female will influence her future offspring, whether prereproductive enrichment to the dam, or postweaning enrichment to the offspring, can reverse the transgenerational effects of stress, and whether, like adversity, enrichment might have transgenerational effects. Female rats were exposed to stressors when they were 27-29 days old. Half of these females and their controls were then raised in an enriched environment from weaning until mating at 60 days to examine whether preproduction enrichment reverses the effects of preproduction stress on offspring. Half of the offspring of each group were raised in an enriched environment after weaning, to see whether it reverses the effects of preproduction stress and buttresses prereproductive enrichment. Behavior was examined in 625 adult offspring in 16 groups covering all permutations of the experimental variables (preproduction weanling stress (PS), preproduction enrichment (PE), offspring enrichment (OE), sex). Exploration, avoidance learning, startle, and social interaction were tested. Results reveal that very early prereproductive experience in females, adverse or enriching, will transgenerationally influence their future offspring, depending on the behavior tested and sex. Our finding that enrichment, whether to the parent or offspring generation, can ameliorate the transgenerational impact of adversity, has novel implications for the malleability of transgenerational inheritance, and its individual, social, and therapeutic impact.

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Can the Behaviour Abnormalities Induced by Gestational Stress in Rats be Prevented or Reversed?

Cited by 37 publications

References 99 publications

Prenatal stress and risk for autism

Prenatal stress and risk for autism

Participação do sistema opioidérgico e dos glicocorticóides nas alterações comportamentais e da imunidade inata induzidas na prole pelo estresse pré-natal

Transgenerational effects of infantile adversity and enrichment in male and female rats

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