Can the choice reaction time be modified after COVID-19 diagnosis? A prospective cohort study

Luvizutto, Gustavo José; Sisconetto, Angélica Taciana; Appelt, Pablo Andrei; Sucupira, Kelly Savana Minaré Baldo; Neto, Eduardo de Moura; Souza, Luciane Aparecida Pascucci Sande de

doi:10.1590/1980-5764-dn-2021-0116

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Luvizutto et al showed that choice reaction time can be decreased after COVID-19 diagnosis over 1 year, and this alteration was associated with decreased cognitive function during multiple tasks. 47 Some studies have shown that COVID-19 can also alter the brain’s functional connectivity pattern, causing brain fog and cognitive dysfunction for months after infection resolution. 11,21,48 Loss of executive function, reduced sustained attention, and slow reasoning for motor responses during everyday tasks in COVID-19 patients can lead to difficulties in performing multiple tasks.…”

Section: Discussionmentioning

confidence: 99%

Post-coronavirus disease 2019 functional impairments, limitations, and restrictions: A prospective cohort study based on the international classification of functioning, disability, and health

Monteiro,

Appelt,

Sisconetto

et al. 2023

J Cent Nerv Syst Dis

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Background Current knowledge regarding coronavirus disease 2019 (COVID-19) is constantly evolving, and the long-term functional impairments, limitations, and restrictions have not yet been well established. Objective to evaluate the impact of post-COVID condition on the human functioning through the International Classification of Functioning, Disability and Health (ICF) classification. Methods This is a prospective cohort study with 53 individuals with post-COVID condition at 3 time points: 0 to 3 (baseline), 3 to 6, and 6-12 months (follow-up). Outcomes were organized in dichotomous variable: No impairment (0); presence of impairment (≥1) in body function, structure, activities, and participation domains according to the ICF checklist. Chi-square test was used to determine the differences of 3 time points, and association with persistent symptoms. Results A statistically significant difference was observed between the periods, with greater disabilities at 6-12 than at 0-3 months in mental, sensory, pain, and movement-related functions; cardiovascular, immunological, and respiratory systems. In terms of activity and participation, a greater limitation at 6-12 months was observed than at 0-3 months in learning and applying knowledge, general tasks, and mobility. In the domain of interpersonal interactions and relationships, there was a statistically significant difference between the 6-12 and 3-6 months groups. Associations between COVID-19 symptoms and ICF components at the first follow-up were: anosmia and dysgeusia with weight maintenance, fatigue and irritability with pain, brain fog with watching and listening, walking difficulty with pain, and headache with pain, watching, and listening. At the second follow-up were: anosmia and dysgeusia with energy and drive functions, attention, memory, and emotional functions; dizziness with watching and listening; fatigue with emotional function, pain, undertaking multiple tasks, lifting and carrying objects, and driving; irritability with energy and drive, emotional function, undertaking multiple tasks, lifting and carrying objects, and walking; walking difficulty with energy and driving, emotional function, respiration, muscle power, cardiovascular system, undertaking multiple tasks, lifting and carrying objects, and walking; and headache with emotional function, watching, and listening. Conclusions Individuals with COVID-19 persistent symptoms showed impairments in structure and function, activity limitations, and participation restrictions during the 1-year follow-up period.

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Section: Discussionmentioning

confidence: 99%

Post-coronavirus disease 2019 functional impairments, limitations, and restrictions: A prospective cohort study based on the international classification of functioning, disability, and health

Monteiro,

Appelt,

Sisconetto

et al. 2023

J Cent Nerv Syst Dis

Self Cite

View full text Add to dashboard Cite

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Meta-analysis of Cognitive Function Following Non-severe SARS-CoV-2 Infection

Austin,

Thomas,

et al. 2024

Neuropsychol Rev

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Post-Concussion Assessment as a diagnostic and mechanistic framework for treating patients with Long COVID

Davidson

Noteboom

Pierro

et al. 2022

Preprint

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IntroductionDespite first coming into view over two years ago, effective diagnostic and treatment pathways for Long COVID continue to evade the medical community. The overlap in neurological-based symptoms and neuroinflammatory origin indicates that the framework of post-concussion syndrome may provide insight into new diagnostics and treatment for patients with Long COVID. The objective of this investigation was to determine whether tools from the four common domains of concussion assessment were sensitive to differentiate between patients with Long COVID from a reference group who was infected with Sars-CoV-2 and does not have Long COVID.MethodsIn this prospective cohort design, each participant self reported their group (Acute, n=28) and Long COVID Group (n=33). Each participant underwent an examination in four assessment categories: symptoms, vestibular nystagmography, Automated Neuropsychological Assessment Metrics (ANAM), and a series of balance tasks.ResultsTotal Symptom scores were separated into functional classifications and showed clear success as a tool to differentiate between Acute and Long COVID. Five of the 33 people in the Long COVID had detectable central lesions, which increases the risk of developing long COVID by 64% (Relative Risk=1.64). A wide variety of objective and quantitative measures from post-concussion care are sensitive to the Long COVID condition. Prolonged latency during random saccades eye tracking was present (p<0.01, d=0.87) in the Long COVID group corresponding to the King-Devick rapid reading test, which was highly sensitive to Long COVID (p<0.01, d=1.34). ANAM reaction time subtests had similarly large effects (p<0.01, d=0.93-1.09). Balance performance with corrupted sensory feedback was also sensitive (p<0.01, d=0.96).DiscussionOur results indicate that long-standing and validated post-concussion symptom questionnaires may be used for quantifying the severity of Long COVID. Some of the most sensitive measures (especially the King-Devick rapid reading test) are easy to implement clinically and may be effective at tracking patient progress in the context of Long COVID treatment. The results point to wide deficits in motor integration and provide a rationale for treating the subset of Long COVID patients with similar rehabilitation strategies as patients with post-concussion syndrome.

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Can the choice reaction time be modified after COVID-19 diagnosis? A prospective cohort study

Cited by 4 publications

References 27 publications

Post-coronavirus disease 2019 functional impairments, limitations, and restrictions: A prospective cohort study based on the international classification of functioning, disability, and health

Post-coronavirus disease 2019 functional impairments, limitations, and restrictions: A prospective cohort study based on the international classification of functioning, disability, and health

Meta-analysis of Cognitive Function Following Non-severe SARS-CoV-2 Infection

Post-Concussion Assessment as a diagnostic and mechanistic framework for treating patients with Long COVID

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