Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

Fecteau, Shirley

doi:10.1016/j.brs.2014.11.021

Cited by 10 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, these results indicate the existence of tDCS‐induced modulatory top‐down effects, which lead to a down regulation of the autonomous and neuroendocrine system . The HPA is regulated by the hypothalamus, which appears to be affected directly or indirectly by tDCS . However, because our study comprised a proof‐of‐principle human trial, we can only speculate about the underlying molecular mechanisms responsible for the observed decreased cortisol levels.…”

Section: Discussionmentioning

confidence: 74%

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

Wardzinski¹,

Friedrichsen²,

Dannenberger³

et al. 2019

J Neuroendocrinology

View full text Add to dashboard Cite

Transcranial direct current stimulation (tDCS) is a neuromodulatory method that has been tested experimentally and has already been used as an adjuvant therapeutic option to treat a number of neurological disorders and neuropsychiatric diseases. Beyond its well known local effects within the brain, tDCS also transiently promotes systemic glucose uptake and reduces the activity of the neurohormonal stress axes. We aimed to test whether the effects of a single tDCS application could be replicated upon double stimulation to persistently improve systemic glucose tolerance and stress axes activity in humans. In a single‐blinded cross‐over study, we examined 15 healthy male volunteers. Anodal tDCS vs sham was applied twice in series. Systemic glucose tolerance was investigated by the standard hyperinsulinaemic‐euglycaemic glucose clamp procedure, and parameters of neurohormonal stress axes activity were measured. Because tDCS‐induced brain energy consumption has been shown to be part of the mechanism underlying the assumed effects, we monitored the cerebral high‐energy phosphates ATP and phosphocreatine by 31phosphorus magnetic resonance spectroscopy. As hypothesised, analyses revealed that double anodal tDCS persistently increases glucose tolerance compared to sham. Moreover, we observed a significant rise in cerebral high‐energy phosphate content upon double tDCS. Accordingly, the activity of the neurohormonal stress axes was reduced upon tDCS compared to sham. Our data demonstrate that double tDCS promotes systemic glucose uptake and reduces stress axes activity in healthy humans. These effects suggest that repetitive tDCS may be a future non‐pharmacological option for combating glucose intolerance in type 2 diabetes patients.

show abstract

Section: Discussionmentioning

confidence: 74%

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

Wardzinski¹,

Friedrichsen²,

Dannenberger³

et al. 2019

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Other studies excluded the abuse/dependency 4 weeks, 15 3 months, 34 and 6 months prior to study inclusion. 11,15,19,23,24,30 Finally, some studies 9,26,42,45 excluded a current drug abuse/dependency at the time of study start.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One tDCS pilot study showed that S96 A. Hasan et al tDCS can improve both auditory hallucinations as well as negative symptoms in severely affected schizophrenia patients. 11 Especially, the improvement of negative symptoms following tDCS deserves particular attention as negative symptoms and cognitive impairments are considered to be correlated. 12 Negative symptoms and cognitive impairments have separable but related etiologies, whereas alternative models describing common or independent etiologies are also deemed as possible.…”

Section: Introductionmentioning

confidence: 99%

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

View full text Add to dashboard Cite

Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The main objective of this review was to systematically evaluate the cognitive effects of repetitive NIBS in schizophrenia. As most studies have not been specifically designed to investigate cognition as primary outcome, we have focused on both, primary and secondary outcomes. The PubMed/MEDLINE database (1985-2015) was systematically searched for interventional studies investigating the effects of repetitive NIBS on schizophrenia symptoms. All interventional clinical trials using repetitive transcranial stimulation, transcranial theta burst stimulation, and transcranial direct current stimulation for the treatment of schizophrenia were extracted and analyzed with regard to cognitive measures as primary or secondary outcomes. Seventy-six full-text articles were assessed for eligibility of which 33 studies were included in the qualitative synthesis. Of these 33 studies, only 4 studies included cognition as primary outcome, whereas 29 studies included cognitive measures as secondary outcomes. A beneficial effect of frontal NIBS could not be clearly established. No evidence for a cognitive disruptive effect of NIBS (temporal lobe) in schizophrenia could be detected. Finally, a large heterogeneity between studies in terms of inclusion criteria, stimulation parameters, applied cognitive measures, and follow-up intervals was observed. This review provides the first systematic overview regarding cognitive effects of repetitive NIBS in schizophrenia.

show abstract

“…In a small clinical study, left amygdala volume was increased following TMS and this change was associated with the antidepressant treatment response [102]. TMS may also modulate brain activity and neurotransmitters, such as serotonin and dopamine [103]. One hypothesis is that depressive patients have impaired modulation of cortical excitability and TMS may alter this imbalance [104].…”

Section: Brain Stimulation In the Treatment Of Depressionmentioning

confidence: 99%

New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity

2017

View full text Add to dashboard Cite

Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders. In this review, we discussed new treatment directions of depression, including modulation of glutamatergic system and noninvasive brain stimulation. Dysfunction of glutamatergic neurotransmission plays an important role in the pathophysiology of depression. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies. In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials. Noninvasive brain stimulation is another new treatment strategy beyond pharmacotherapy. Growing evidence has demonstrated that superficial brain stimulations, such as transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, and magnetic seizure therapy, can improve depressive symptoms. The antidepressive effect of these brain stimulations may be through modulating neuroplasticity. In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression. Furthermore, exploring the underlying mechanisms will help in developing novel therapies for depression in the future.

show abstract

Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

Cited by 10 publications

References 41 publications

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity

Contact Info

Product

Resources

About