Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study

Itsiopoulos, Catherine; Brazionis, Laima; Kaimakamis, Mary; Cameron, Melissa A; Best, James D.; O’Dea, Kerin; Rowley, Kevin

doi:10.1016/j.numecd.2010.03.005

Cited by 143 publications

(153 citation statements)

References 38 publications

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“…In fact, large prospective studies have shown that adherence to Mediterranean Diet is inversely correlated with the risk of presenting type 2 diabetes mellitus Mozaffarian et al, 2007), which has been eventually corroborated (de Koning et al, 2011;Delgado-Lista et al, 2011b;. Some authors have published, indeed, that changing from a saturated fat rich diet to a Mediterranean Diet results in a decrease of glycated hemoglobin of around 0.3-2.0%, which is close to the efficacy of some antidiabetic drugs, and allow to reduce pharmacological needs of these patients, which has also been reproduced when comparing Mediterranean Diet with a low fat diet (Elhayany et al, 2010;Itsiopoulos et al, 2010;Reisin, 2010). A recent randomized clinical trial showed that the risk of incident diabetes is reduced by more than 50% when Mediterranean Diet (either with or without supplements of nuts) is compared with the low-fat group (p<0.05) (SalasSalvado et al, 2011a).…”

Section: Cardiovascular Risk Factors 472mentioning

confidence: 76%

Mediterranean Diet and Cardiovascular Risk

Delgado‐Lista¹,

Perez-Caballero²,

Pérez‐Martínez³

et al. 2012

Cardiovascular Risk Factors

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Section: Cardiovascular Risk Factors 472mentioning

confidence: 76%

Mediterranean Diet and Cardiovascular Risk

Delgado‐Lista¹,

Perez-Caballero²,

Pérez‐Martínez³

et al. 2012

Cardiovascular Risk Factors

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“…The RCT by Itsiopoulous et al showed participants coming down from a 7.1% to 6.8% HbA1C on average [8]. The study completed by Espino et al revealed an inverse relationship between adherence to the diet and HbA1C [6].…”

Section: Discussionmentioning

confidence: 99%

“…In a randomized cross-over study by Itsiopoulos et al, twenty-seven subjects (age 47-77) with type two diabetes were randomly assigned to consume either an intervention diet (Mediterranean diet) or their usual diet for 12 weeks and then cross over to the alternate diet [8]. The purpose of the study was to determine if diet had an overall effect on HbA1c levels.…”

Section: Literature Reviewmentioning

confidence: 99%

Mediterranean Diet and Its Effects on Preventing and Managing Type Two Diabetes: A Literature Review

Adams¹,

Schryver²,

Tetarenko³

2017

Primary Health Care

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Diabetes has become a major epidemic in the United States. In 2012, 29.1 million Americans had type 2 diabetes and it is projected that there will be 1.4 million new cases each year. Having diabetes is a major risk factor for cardiovascular disease, renal disease, blindness and limb amputation. Due to the debilitating effects and complications diabetes can have on one's body, research has been conducted to find the best ways to prevent this chronic illness.Diet tends to be a primary focus around diabetes prevention. A Mediterranean-style diet has been suggested as a good diet plan to prevent type 2 diabetes. A Mediterranean diet consists of high consumption of fruits and vegetables, whole grains, legumes and nuts, moderate intake of seafood and poultry with very minimal intake of red meat. Olive oil is the primary source of fat as well as a moderate intake of wine with meals. The diet suggests avoiding foods with added sugars, refined grains, Tran's fats and anything highly processed. According to the literature, this diet can be used to prevent and also help control already diagnosed diabetics.A review of the literature was performed to determine if there is enough evidence to support recommending a Mediterranean diet as a method of preventing and managing type 2diabetes. The literature shows an overwhelming trend that following a Mediterranean diet can help lower the incidence of type 2 diabetes and reduce haemoglobin A1C in those already diagnosed.

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“…Good adherence with the MedDiet underpins essentially any health benefits achieved -if for any number of cultural, genetic, environmental or other reasons the MedDiet was unacceptable in Australia, it would not be a useful intervention. One small study (n = 27) amongst Australian-born adults with Type 2 diabetes gave participants a traditional MedDiet for 12 weeks, and volunteers achieved high compliance to the diet [17]. However almost all (minimum of 70 %) of the diet was provided as pre-prepared foods.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of the MedDiet on cardiovascular biomarkers and end-points has previously been tested in European populations with positive outcomes [11,12,16]. However, only one small (n = 20) randomised cross-over trial has been conducted in Australia on markers of diabetes severity [17]. With promising results in other countries, studies are needed to determine if this dietary pattern is a viable option to improve markers of cardiometabolic health and potentially reduce incident CVD in non-Mediterranean populations like Australia.…”

Section: Introductionmentioning

confidence: 99%

A randomised controlled intervention trial evaluating the efficacy of an Australianised Mediterranean diet compared to the habitual Australian diet on cognitive function, psychological wellbeing and cardiovascular health in healthy older adults (MedLey study): protocol paper

et al. 2015

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Background: The Mediterranean diet (MedDiet) is associated with considerable health benefits for cardiovascular and cognitive health, particularly within the Mediterranean basin. Whether Australian populations will similarly benefit from the MedDiet is unknown. We aim to assess the effects of a MedDiet on cognitive and cardiovascular health indicators amongst the elderly (MedLey study). Here we describe in detail the protocol for the MedLey study. Methods: Medley is a randomised, parallel controlled dietary intervention trial. Data collection occurred at the Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia between 2013 and 2015. Omnivorous men and women aged ≥65 years, who were non-smokers, had no previously diagnosed cardiovascular disease, history of brain trauma, cognitive impairment, major disease or cancer were recruited from the general public (n = 166). The intervention comprised an Australianised version of the traditional MedDiet characterised by small amounts of red meat, processed deli meats and high sugar foods; moderate amounts of dairy and poultry; and a high plant food content including abundant extra virgin olive oil. Volunteers were stratified by age, gender and body mass index (kg/m 2 ) to follow either their habitual diet (control condition) or the intervention MedDiet for 24 weeks. Primary outcome measures included cognitive function, endothelial function, cerebrovascular flow, blood lipids, inflammatory markers, fasting glucose and insulin, blood pressure, and body composition. Secondary outcomes included food cravings, psychological wellbeing and DNA damage markers. These were assessed at baseline, 12 and 24 weeks. Dietary intakes were assessed at baseline, two and four months to assess adherence to the prescribed diet. For main outcome measures, groups will be compared over time using a linear mixed effects model, with Cohen's d effect sizes. Subgroup analysis based on adherence to the intervention, medications and alcohol consumption may be performed in an exploratory fashion.

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Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study

Cited by 143 publications

References 38 publications

Mediterranean Diet and Cardiovascular Risk

Mediterranean Diet and Cardiovascular Risk

Mediterranean Diet and Its Effects on Preventing and Managing Type Two Diabetes: A Literature Review

A randomised controlled intervention trial evaluating the efficacy of an Australianised Mediterranean diet compared to the habitual Australian diet on cognitive function, psychological wellbeing and cardiovascular health in healthy older adults (MedLey study): protocol paper

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