Can the microcirculatory response to hypoxia be a prognostic factor for Covid-19?

Gębicki, Jerzy; Katarzyńska, Joanna; Marcinek, Andrzej

doi:10.1016/j.resp.2020.103478

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…7,8,13,14 In previous communications, we have suggested that the Hypoxia Sensitivity (HS) parameter can be used to predict severity of the acute phase of COVID-19 infection. 26,27 However, the present study indicates that this parameter now 2. The explanation may be that hypoxemia plays an important role only in the acute phase of infection.…”

Section: Resultscontrasting

confidence: 67%

Chronic Fatigue Associated with Post-COVID Syndrome versus Transient Fatigue Caused by High-Intensity Exercise: Are They Comparable in Terms of Vascular Effects?

Chudzik¹,

Cender²,

Mordaka³

et al. 2022

VHRM

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Purpose The pathophysiology of chronic fatigue associated with post-COVID syndrome is not well recognized. It is assumed that this condition is partly due to vascular dysfunction developed during an acute phase of infection. There is great demand for a diagnostic tool that is able to clinically assess post-COVID syndrome and monitor the rehabilitation process. Patients and Methods The Flow Mediated Skin Fluorescence (FMSF) technique appears uniquely suitable for the analysis of basal microcirculatory oscillations and reactive hyperemia induced by transient ischemia. The FMSF was used to measure vascular circulation in 45 patients with post-COVID syndrome. The results were compared with those for a group of 26 amateur runners before and after high-intensity exercise as well as for a control group of 32 healthy age-matched individuals. Results Based on the observed changes in the NOI (Normoxia Oscillatory Index) and RHR (Reactive Hyperemia Response) parameters measured with the FMSF technique, it was found that chronic fatigue associated with post-COVID syndrome is comparable with transient fatigue caused by high-intensity exercise in terms of vascular effects, which are associated with vascular stress in the macrocirculation and microcirculation. Acute and chronic fatigue symptomatology shared similarly altered changes in the NOI and RHR parameters and both can be linked to calcium homeostasis modification. Conclusion The NOI and RHR parameters measured with the FMSF technique can be used for non-invasive clinical assessment of post-COVID syndrome as well as for monitoring the rehabilitation process.

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Section: Resultscontrasting

confidence: 67%

Chronic Fatigue Associated with Post-COVID Syndrome versus Transient Fatigue Caused by High-Intensity Exercise: Are They Comparable in Terms of Vascular Effects?

Chudzik¹,

Cender²,

Mordaka³

et al. 2022

VHRM

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“…In a recent communication, we proposed that the microcirculatory response to hypoxia could be a prognostic factor for COVID-19 ( Gebicki et al, 2020b ). This was supported by extensive literature linking innate immunity directly to hypoxia ( Colgan et al, 2020 ).…”

mentioning

confidence: 99%

Can efficient stimulation of myogenic microcirculatory oscillations by transient ischemia predict low incidence of COVID-19 infection?

Gębicki

Katarzyńska²,

Marcinek

2021

Respiratory Physiology & Neurobiology

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“…However, the present study indicates that this parameter has only minor utility for the diagnostics of post-COVID syndrome, as shown in Table 2. 18,19 The explanation may be that hypoxemia plays an important role only in the acute phase of infection.…”

Section: Resultsmentioning

confidence: 99%

Chronic fatigue associated with post-COVID syndrome versus transient fatigue caused by high intensity exercise: are they comparable in terms of vascular effects?

Chudzik

Cender²,

Mordaka³

et al. 2022

Preprint

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Purpose: The pathophysiology of chronic fatigue associated with post-COVID syndrome is not well recognized. It is assumed that this condition is partly due to vascular dysfunction developed during an acute phase of infection. There is great demand for a diagnostic tool that is able to clinically assess post-COVID syndrome and monitor the rehabilitation process. Patients and Methods: The Flow Mediated Skin Fluorescence (FMSF) technique appears uniquely suitable for the analysis of basal microcirculatory oscillations and reactive hyperemia induced by transient ischemia. The FMSF was used to measure vascular circulation in 45 patients with post-COVID syndrome. The results were compared with those for a group of 26 amateur runners before and after high intensity exercise, as well as for a control group of 32 healthy age-matched individuals. Results: Based on the NOI and RHR parameters measured with the FMSF technique, it was found that chronic fatigue associated with post-COVID syndrome is comparable with transient fatigue caused by high-intensity exercise in terms of vascular effects. Both chronic fatigue associated with post-COVID syndrome and transient fatigue caused by high-intensity exercise are associated with vascular stress in the macrocirculation and microcirculation. Conclusion: The NOI and RHR parameters measured with the FMSF technique can be used for non-invasive clinical assessment of post-COVID syndrome, as well as for monitoring the rehabilitation process.

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Can the microcirculatory response to hypoxia be a prognostic factor for Covid-19?

Cited by 8 publications

References 8 publications

Chronic Fatigue Associated with Post-COVID Syndrome versus Transient Fatigue Caused by High-Intensity Exercise: Are They Comparable in Terms of Vascular Effects?

Chronic Fatigue Associated with Post-COVID Syndrome versus Transient Fatigue Caused by High-Intensity Exercise: Are They Comparable in Terms of Vascular Effects?

Can efficient stimulation of myogenic microcirculatory oscillations by transient ischemia predict low incidence of COVID-19 infection?

Chronic fatigue associated with post-COVID syndrome versus transient fatigue caused by high intensity exercise: are they comparable in terms of vascular effects?

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