Can the Obese Phenotype Occur Via Epigenetic Expression?

Glucocorticoid ablation restores glycemic and thermogenic parameters in obesity

“…Therefore, pharmacologic or surgical ablation of adrenal glucocorticoid inhibitory activity would seem to be an effective strategy to restore GLUT4 transporter functions, permit the restoration of endoplasmic reticulum synthesis and intracellular translocation to the plasma membranes, improve cellular glucose uptake and oxidation, and thus diminish the overall magnitude of insulin resistance in the various tissues of the obese phenotype of this and other genetically obese rat strains. Insulin is known to impact multiple aspects of energy metabolism and storage, including lipogenesis, activation of preadipocytes, and substrate oxidative processes, all of which may serve as primary or secondary factors that contribute to excess energy storage in adipocytes and other tissues, including hepatic fatty acid and glycogen synthesis and storage [35][36][37]. .…”