CAN THE OVARIAN HORMONES INHIBIT THE MAMMARY RESPONSE TO PROLACTIN?<sup>1</sup>

Meites, Joseph; Sgouris, J. T.

doi:10.1210/endo-53-1-17

Cited by 27 publications

(9 citation statements)

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“…In contrast, oestrogens have been widely used in women to inhibit lactation (Cowie & Tindal, 1971). In addition, Meites & Sgouris (1953) and more recently, Denamur, Delouis & Gaye (1970) have shown that in the ovariectomized pseudopregnant rabbit, progesterone and oestrogen combinations can inhibit the initiation of milk secretion by prolactin. In this context it is difficult to interpret the interaction between oestrogen and progesterone which resulted in an increased concentration of lactose in the milk (Fig.…”

mentioning

confidence: 99%

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Hartmann¹,

Trevethan²,

Shelton³

1973

Journal of Endocrinology

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The concentrations of lactose and progesterone were determined in mammary secretion and blood plasma, respectively, collected from ten ewes at daily intervals from 30 days before to 10 days after parturition. An initial increase in the concentration of lactose in the mammary secretion occurred as early as 30 days before parturition and was not related to changes in the concentration of progesterone in the peripheral plasma. On the other hand, there was a rapid fall in the concentration of progesterone in the peripheral plasma from 1 to 4 days before parturition and this fall was closely related to a second rapid increase in the concentration of lactose in the mammary secretion. The foetuses were removed from an additional 12 ewes by Caesarean section at 144 days of gestation; three ewes received no hormone therapy; three ewes received 62\m=.\5mg progesterone/12 h for 5 days; three ewes received 2\m=.\0 mg oestradiol at 12, 24 and 36 h respectively after surgery; three ewes received both progesterone and oestrogen therapy.Whereas progesterone inhibited the increase in milk yield and lactose concentration after Caesarean section, progesterone and oestrogen in combination inhibited only the increase in milk yield. These results suggest that progesterone withdrawal initiates lactogenesis in the ewe.

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mentioning

confidence: 99%

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Hartmann¹,

Trevethan²,

Shelton³

1973

Journal of Endocrinology

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“…Prolactin has, of course, for some time, been considered to be of principal importance in lactogenesis and its significance in the initiation of lactation has been dealt with by Meites and his co-workers in a series of papers (220,221,222,309). These workers find that if oestrogen and progesterone are given in the amount necessary for producing mammary growth in spayed rabbits, milk secretion as a result of prolactin administration is inhibited unless 4 mg. or more of prolactin (20-25 i.u.…”

Section: Anterior-pituitary Hormonesmentioning

confidence: 99%

Section A. Physiology of dairy cattle: Hormones in reproduction and lactation

Benson

Cowie

1957

Journal of Dairy Research

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“…Oestrogens are known to inhibit lactation in different animal species (Fields, 1945;Meites & Sgouris, 1953; Ben-David, Rodering, Khazen & Sulman, 1965). Although there is evidence for a direct action of oestrogens upon mammary function (Meites & Sgouris, 1953;BenDavid et al 1965), the actual mechanism involved is almost unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Although there is evidence for a direct action of oestrogens upon mammary function (Meites & Sgouris, 1953;BenDavid et al 1965), the actual mechanism involved is almost unknown. Previous work (Bruce, Cofré & Ramirez, 1973fl) has suggested that oestrogen implanted in rat mammary tissue may block the response to oxytocin.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Mammary Gland in Lactating Rats After Local Implantation of Oestrogen

Zamora¹,

Mendoza²,

Ramírez³

1975

Journal of Endocrinology

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Cannulae containing oestrogen were implanted in the mammary glands of rats on the first day after parturition and lactation assessed by daily measurements of the litter weight. Sham-implanted and intact lactating rats were used as controls. A clear-cut inhibition of the milk yield was observed in the oestrogen-implanted group. Mammary tissue was processed for fine structural study after 4, 8 or 10 days. The initial phase showed milk stasis and secretion of colostrum progressively involving the alveoli and culminating in regression of the mammary tissue. Disappearance of myofilaments from the myoepithelial cells was consistently observed. Secretion of colostrum and mammary regression could be the result of the stasis produced by an abnormal dynamic state of the myoepithelial cell elicited by the steroid.

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CAN THE OVARIAN HORMONES INHIBIT THE MAMMARY RESPONSE TO PROLACTIN?¹

Cited by 27 publications

References 0 publications

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Section A. Physiology of dairy cattle: Hormones in reproduction and lactation

Ultrastructure of the Mammary Gland in Lactating Rats After Local Implantation of Oestrogen

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CAN THE OVARIAN HORMONES INHIBIT THE MAMMARY RESPONSE TO PROLACTIN?1

Cited by 27 publications

References 0 publications

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Progesterone and Oestrogen and the Initiation of Lactation in Ewes

Section A. Physiology of dairy cattle: Hormones in reproduction and lactation

Ultrastructure of the Mammary Gland in Lactating Rats After Local Implantation of Oestrogen

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CAN THE OVARIAN HORMONES INHIBIT THE MAMMARY RESPONSE TO PROLACTIN?¹