Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?

Ferreira, David; Silva, Priscila Vieira da; Oliveira, Haroldo César de; Rocha, Kellyth Andrade Pereira; Silva, Diego Romário da; Pitangui, Nayla de Souza; Sardi, Janaína de Cássia Orlandi

doi:10.1007/s12281-023-00470-4

Curr Fungal Infect Rep

2023

DOI: 10.1007/s12281-023-00470-4

|View full text |Cite

Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?

David Ferreira

Priscila Vieira da Silva

Haroldo César de Oliveira

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes

dos Santos,

Zangirolami,

Ferreira Vicente

et al. 2024

Photochem & Photobiology

View full text Add to dashboard Cite

Fungal infections related to biofilm formation on medical devices, such as endotracheal tubes (ETTs), pose significant health risks, especially during intubation procedures where fungi like Candida spp. can migrate into the lower respiratory tract. This study explores the use of Photodynamic Therapy (PDT) to prevent fungal cell migration from ETT surfaces to lungs, focusing on the role of curcumin as a photosensitizer. ETTs were coated with varying concentrations of curcumin, and biofilm formation was measured after applying PDT with a 50 J/cm2 irradiation dose. The study found that ETTs functionalized with a one‐third concentration of CUR reduced biofilm formation by 1.78 Log, significantly lowering microbial load and potentially decreasing hospital‐acquired infections. Confocal fluorescence microscopy confirmed that PDT damaged the biofilm's extracellular matrix and caused detachment of dead fungal cells. Moreover, the fluorescence analysis reveals the photodegradation behavior of the photosensitizer within the tube, providing critical insights into its stability and durability, which are essential for evaluating the long‐term applicability of these tubes in clinical settings. These results suggest PDT as a promising strategy to reduce fungal infections in high‐risk patients, offering potential for future clinical application in preventing device‐associated infections.

show abstract

Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes

dos Santos,

Zangirolami,

Ferreira Vicente

et al. 2024

Photochem & Photobiology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?

Cited by 1 publication

References 63 publications

Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes

Photodynamic therapy as a potential approach for preventing fungal spread associated with the use of endotracheal tubes

Contact Info

Product

Resources

About