Can tissue engineering produce bioartificial organs for transplantation?

Ice, ice, maybe? Is it time to ditch the igloo cooler? Benefits of machine perfusion preservation of donor hearts

“…Ultimately, the potential to affect the organ during the incubation period is substantial and may even involve interventions to ensure long-term survival by genetically engineering the allograft 67 and applying strategies to induce tolerance, once the recipient has been identified. 68 Similar challenges are currently experienced by researchers developing bioengineered artificial organs and xenotransplantation. Once overcome, long-term organ perfusion systems would revolutionize the field of cardiac transplantation and alleviate donor shortages not only by recovery and resuscitation of most donor hearts, but also use of bioengineered organs, and potentially xenotransplantation.…”

“…Advances in organ culture systems, monitoring and technology are essential to achieve this aim. Ultimately, the potential to affect the organ during the incubation period is substantial and may even involve interventions to ensure long‐term survival by genetically engineering the allograft and applying strategies to induce tolerance, once the recipient has been identified . Similar challenges are currently experienced by researchers developing bioengineered artificial organs and xenotransplantation.…”

Optimization of Complete Rat Heart Decellularization Using Artificial Neural Networks

“…Cross-sections of decellularized scaffolds stained with Masson's trichrome maintained the collagen network but no signs of cardiomyocyte-specific nuclei (Figure 11a,b). Whole heart decellularization and tissue engineering are expected to revolutionize organ transplantation by eliminating the waiting-list mortality and post-procedure immune rejection [23]. Decellularization of native hearts has made significant progress in the last few years and has experienced an increased level of attention among researchers [24,25].…”

Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration

“…The bioengineering of the whole liver has always been clinically attractive because of its therapeutic potential for liver transplantation. A scaffold-based strategy that relies on the use of biomaterials to create a temporary structure able to support all liver cell attachment and proliferation is therefore very attractive and may allow a real improvement in generating 3D tissues readily suitable for transplantation and liver therapy [72,73]. As previously mentioned, despite the increased number of donors in the last decade due to the increasing age, an important part of the livers available is still rejected for OLT.…”