Can Unresolved Infection Precipitate Autoimmune Disease?

Marks, Daniel; Mitchison, N. A.; Segal, Anthony W.; Sieper, Joachim

doi:10.1007/3-540-29714-6_6

Cited by 16 publications

(15 citation statements)

References 113 publications

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“…IL-8 concentration is correlated with MPO concentration in colon and is responsible for an increased CD11b expression and ROS production by neutrophils [13,14]. In contrast, Marks et al showed a defect in neutrophil recruitment associated with a reduced IL-8 production in patients with Crohn’s disease [32,46]. Neutrophil accumulation and IL-8 production are reduced in the intestine of CD patients compared to UC patients and controls.…”

Section: Effects Of Targeting Neutrophil Chemotaxis and Extravasationmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

241

189

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Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entities, and there is some evidence that neutrophil behaviour, above all other aspects of immunity, clearly separate them. Neutrophils are the first immune cells recruited to the site of inflammation, and their action is crucial to limit invasion by microorganisms. Furthermore, they play an essential role in proper resolution of inflammation. When these processes are not tightly regulated, they can trigger positive feedback amplification loops that promote neutrophil activation, leading to significant tissue damage and evolution toward chronic disease. Defective chemotaxis, as observed in Crohn’s disease, can also contribute to the disease through impaired microbe elimination. In addition, through NET production, neutrophils may be involved in thrombo-embolic events frequently observed in IBD patients. While the role of neutrophils has been studied in different animal models of IBD for many years, their contribution to the pathogenesis of IBD remains poorly understood, and no molecules targeting neutrophils are used and validated for the treatment of these pathologies. Therefore, it is crucial to improve our understanding of their mode of action in these particular conditions in order to provide new therapeutic avenues for IBD.

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Section: Effects Of Targeting Neutrophil Chemotaxis and Extravasationmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

241

189

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“…When examined objectively, Crohn's disease does not achieve any of the criteria required for definition as an autoimmune disease, and the evidence for any single infectious agent is not compelling. 9 A source of considerable support for the immunodeficiency hypothesis is the observation that a number of rare congenital disorders of innate immunity (and in particular, phagocyte function) are associated with noninfectious bowel inflammation that is endoscopically, radiologically, and histologically indistinguishable from Crohn's disease. 10 Patients with various neutropenias, leukocyte adhesion deficiency-1 (LAD-1), Hermansky-Pudlak syndrome (HPS), Chediak-Higashi syndrome (CHS), chronic granulomatous disease (CGD), and glycogen storage disease-Ib (GSD-1b) are all reported to develop chronic enterocolitis.…”

mentioning

confidence: 99%

Phagocyte dysfunction and inflammatory bowel disease

Rahman

Marks

Hayee

et al. 2008

Inflammatory Bowel Diseases

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Inflammatory bowel diseases are common chronic inflammatory disorders. The majority are idiopathic and can be broadly divided into Crohn's disease and ulcerative colitis. Their cause is unknown, but most hypotheses focus on a primary role for T-cell dysfunction. Conversely, there is a collection of congenital disorders of phagocyte function that result not only in immunodeficiency but also in noninfectious inflammatory bowel disease. In all cases, the latter is strikingly reminiscent of the clinical and pathological features of Crohn's disease. This coincides with recent work demonstrating that despite previous emphasis on adaptive immune dysfunction, patients with Crohn's disease actually possess an unusually weak acute innate inflammatory response. This review consolidates the literature on inflammatory bowel disease in congenital immunodeficiencies and considers the role of phagocyte dysfunction in Crohn's disease. Concepts about pathogenesis and treatment that can be carried across these disorders are also discussed.

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“…The production of autoreactive T cells and autoantibodies may rely on the continued presence of the infectious organism or its residual antigen, but involvement of self‐antigens can not be excluded. The involvement of self‐antigens could be due to several mechanisms such as epitope spreading, polyclonal activation of T or B cells by mitogens of the invading organism and loss of downregulation that occurs within DC clusters 6 …”

Section: Pathogenesis Of Autoimmune Diseases and The Potential Role Omentioning

confidence: 99%

“…A possible explanation for autoimmune responses after influenza infection suggests loss of downregulation within DC clusters leading to an increased proportion of activated cells. Moreover, B cells are activated directly through TLR in influenza infection and indirectly by induction of IFN alpha and in such an activated state might come to polyclonal activation and production of autoantibodies 6 …”

Section: Immunity Of Influenza Infection/vaccination and Pathogenesismentioning

confidence: 99%

Influenza and Autoimmunity

Toplak

Avčin

2009

Annals of the New York Academy of Sciences

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Influenza infection can cause mild to severe illness and can even lead to death. The best way to prevent infection is vaccination against influenza. Complications of influenza infection are not only a consequence of acute infection but can also present as late autoimmune response. Influenza is not frequently implicated as a trigger for autoimmune diseases, but case reports of autoimmune adverse events have been published even following influenza vaccination. In this article we review published data on autoimmune diseases following influenza infection and vaccination. We also discuss immunity of influenza infection in connection to pathogenesis of autoimmune response and autoimmune disease.

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Can Unresolved Infection Precipitate Autoimmune Disease?

Cited by 16 publications

References 113 publications

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Phagocyte dysfunction and inflammatory bowel disease

Influenza and Autoimmunity

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