Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

Göğer, Yunus Emre; Özkent, Mehmet Serkan; Topcu, Cemile; Atıcı, Ahmet; Sönmez, Mehmet Giray; Balasar, Mehmet; Gürbîlek, Mehmet

doi:10.1159/000517883

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…This could be attributed to the stone clearance and/or use of NSAIDs, which might have had a favourable impact on the inflammatory process and their associated biomarkers. Similar results for urinary KIM-1/Cr and urinary NGAL/Cr ratios were recorded after ureteroscopy [18].…”

Section: Discussionsupporting

confidence: 82%

The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

et al. 2023

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ObjectivesTo compare the efficacy and safety of shockwave lithotripsy (SWL) using a narrow focus or wide focus for renal stones.Patients and MethodsA double‐blind randomised trial included adult patients with a solitary radio‐opaque renal pelvic stone of 1–2 cm. Patients were randomised into two groups: narrow‐focus (2 mm) SWL and wide‐focus (8 mm) SWL. The stone‐free rate (SFR) and presence of complications such as haematuria, fever, pain, and peri‐renal haematoma were evaluated. Pre‐ and postoperative urinary markers (neutrophil gelatinase‐associated lipocalin [NGAL] and kidney injury molecule 1 [KIM‐1]) concentrations were compared to assess renal injury.ResultsA total of 135 patients were recruited for this study. The SFR after the first SWL session was 79.2% and 69.1% in narrow‐ and wide‐focus groups, respectively. There was a comparable rise in the median 2‐h NGAL concentration in both groups (P = 0.62). However, the rise in the median (interquartile range [IQR]) 2‐h KIM‐1 concentration was significantly higher in the narrow‐focus group at 4.9 (4.6, 5.8) ng/mL compared with the wide‐focus group at 4.4 (3.2, 5.7) ng/mL (P = 0.02). Nevertheless, the 3‐day NGAL and KIM‐1 urinary marker concentrations were significantly improved (P = 0.263 and P = 0.963, respectively). The overall SFR after three sessions was 86.6% and 86.8% in the narrow‐ and wide‐focus groups, respectively (P = 0.77). Both groups were comparable for complications, apart from the median pain score and the percentage of high‐grade haematuria, which were significantly higher in the narrow‐focus group (P < 0.001 and P = 0.03, respectively).ConclusionNarrow‐ and wide‐focus SWL were associated with comparable outcomes and re‐treatment rates. However, narrow‐focus SWL was associated with significantly higher morbidity in terms of pain and haematuria.

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Section: Discussionsupporting

confidence: 82%

The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

et al. 2023

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“…The levels of these biomarkers increase, especially in the early period of nephrotoxic and ischemic renal damage [7,8]. Several studies have shown that the levels of AKI biomarkers can increase after urinary system stone treatments [9][10][11]. In this study, our aim was to investigate the effect of the diameter of UAS used during RIRS on renal injury through the evaluation of AKI biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Ureteral Access Sheath Size on Acute Kidney Injury Biomarkers in Retrograde Intrarenal Surgery: A Prospective, Randomized Study

Aykanat¹,

Balcı²,

Kılınçkaya³

et al. 2023

Urol Int

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Introduction: The aim of the study was to investigate the effect of the diameter of the ureteral access sheath (UAS) used during RIRS on kidney injury based on acute kidney injury (AKI) biomarkers. Methods: This prospectively randomized controlled study included a total of 125 patients divided into three groups: group 1 (n = 52) in which a 12/14 Fr UAS was used, group 2 (n = 52) in which a 9.5/11.5 Fr UAS was used, and group 3 (n = 21) that was designed as the control group with no urogenital disease history. Urine samples were collected preoperatively and at the postoperative second and 24th hours after surgery and analyzed for AKI using the urinary kidney injury molecule-1 (uKIM-1), N-acetyl-ß-D-glucosaminidase, and neutrophil gelatinase-associated lipocain biomarkers. Results: In group 1, there was no statistical change in any of the three AKI biomarkers at the postoperative second or 24th hour compared to the preoperative period. In group 2, the values of all three AKI biomarkers were statistically significantly increased at the postoperative second and 24th hours compared to the preoperative period while no statistical difference was observed between the two postoperative evaluation times. At the postoperative second hour, the uKIM-1 value was statistically significantly higher in group 2 compared to group 1 (p = 0.043). Conclusions: The results of our study showed that AKI was not observed in RIRS performed with a 12/14 Fr UAS while the use of a 9.5/11.5 Fr UAS resulted in AKI according to the assessment of the related biomarkers.

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Outcomes and lessons learnt from practice of retrograde intrarenal surgery (RIRS) in a paediatric setting of various age groups: a global study across 8 centres

et al. 2022

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Can Urinary KIM-1 and NGAL Predict Management Endoscopic Surgery in Acute Unilateral Obstructive Stone Disease? Results from a Prospective Cohort Study

Cited by 5 publications

References 33 publications

The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

The effect of piezoelectric shockwave lithotripsy with 2‐ and 8‐mm focus sizes on stone disintegration and renal injury

Effect of the Ureteral Access Sheath Size on Acute Kidney Injury Biomarkers in Retrograde Intrarenal Surgery: A Prospective, Randomized Study

Outcomes and lessons learnt from practice of retrograde intrarenal surgery (RIRS) in a paediatric setting of various age groups: a global study across 8 centres

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