Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial

Hassani, Soghra; Alipour, Abbas; Darvishi‐Khezri, Hadi; Firouzian, Abolfazl; Zeydi, Amir Emami; Baradari, Afshin Gholipour; Ghafari, Rahman; Habibi, Wali-allah; Tahmasebi, Homeyra; Alipour, Fatemeh; Zadeh, Pooneh Ebrahim

doi:10.1007/s00213-014-3716-x

Cited by 20 publications

(13 citation statements)

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“…This changes in the public mood might have influenced the results, as all assessments took place after May 1, 2014. Recent studies have suggested that valerian is less promising as a sleep aid than earlier studies suggested (Leach & Page, ), but other clinical benefits of valerian are still supported by recent randomized, placebo‐controlled trials (Ahmadi et al, ; Hassani et al, ; Jenabi, Shobeiri, Hazavehei, & Roshanaei, ). Further studies are needed to confirm valerian's efficacy in various clinical populations and determine the optimal dose.…”

Section: Discussionmentioning

confidence: 99%

“…Valerian's effects might be too modest to detect with multidimensional scales. Additional measures of cognitive function (Hassani et al, ) could help identify valerian's clinical benefits in future studies. In addition, study period might be insufficient to produce improvement in anxiety, and low dose‐VRE might require extended treatment course lasting longer than 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Overall, few randomized controlled trials on valerian have been conducted, though those that were conducted have returned consistent results (Ahmadi, Khalili, Abbasian, & Ghaeli, ; Hassani et al, ). We, therefore, conducted a randomized, double‐blinded, placebo‐controlled, parallel‐group trial to examine the therapeutic effects of valerian root extract (VRE) on anxiety and other psychological constructs including depression, cognitive deficits, perceived lack of social support, and occupational dysfunction in nonclinical volunteers suffering psychological stress.…”

Section: Introductionmentioning

confidence: 99%

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Valerian extract alters functional brain connectivity: A randomized double‐blind placebo‐controlled trial

Roh

Jung

Yoon

et al. 2019

Phytotherapy Research

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Valerian root is the most commonly used herbal supplement for sedation and anxiolysis, but it is unknown whether it may affect functional brain connectivity.Our goal was to use electroencephalography (EEG) to investigate whether valerian root extract (VRE) affects resting-state connectivity changes and whether such changes are associated with clinical symptoms. This 4-week, double-blinded, randomized, placebo-controlled clinical trial was conducted with 64 nonclinical volunteers suffering psychological stress. The participants received VRE (100 mg) or a placebo thrice daily. We examined VRE's therapeutic effects on anxiety and stress-related psychological constructs. Functional brain connectivity changes were measured as EEG coherence in the alpha and theta frequency bands. The VRE and placebo groups both exhibited significant postintervention improvements on all clinical scales, but no significant between-group differences in these changes were noted. Compared with the placebo group, the VRE group exhibited significantly greater increases in frontal brain region alpha coherence across four electrode pairs, and these changes were significantly correlated with anxiolysis. The VRE group also exhibited significantly greater decreases in theta coherence across another four electrodes pairs. Our findings indicate that VRE alters functional brain connectivity in relation to anxiety.Further EEG studies are needed to confirm VRE's neurophysiological effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Valerian extract alters functional brain connectivity: A randomized double‐blind placebo‐controlled trial

Roh

Jung

Yoon

et al. 2019

Phytotherapy Research

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“…In a series of recent prospective studies, it has been demonstrated that cognitive impairment after CABG is reversible in a significant part of patients and the majority of patients revert to the initial cognitive status within three to twelve months after surgery (Hassani, Alipour, Darvishi Khezri, Firouzian, Emami Zeydi, Gholipour Baradari, Ebrahim Zadeh, 2015). However, in 42% of patients cognitive impairment persists beyond 5 years after CABG.…”

Section: State Of the Problemmentioning

confidence: 99%

Proceedings of the Iii International Scientific and Practical Conference “Psychological Health of the Person: Life Resource and Life Potential”

2017

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The Proceedings cover different aspects of mental health research concerned with human life resource and life potential, as well as applied aspects of health psychology.The editorial policy was based on the principles of selection and reviewing of all submitted manuscripts. At the first stage all the manuscripts underwent an initial review by the Editor-in-Chief and the Editorial Board before peer-review in order to assess whether their content complied with the Conference theme. The manuscripts which did not comply with the subject matter of the Conference have been rejected. At the second stage all the manuscripts underwent a double blind review process: each work was reviewed by two experts from the Board of Reviewers; reviewing procedure was anonymous both for the experts and authors.In case of positive review results provided by both experts the contributions were included in the Editor-in-Chief Portfolio. At the third stage manuscripts underwent scientific style as well as language literacy assessment and language editing. This work was carried out by the team of Language Editors. Based on the results of the three stages of reviewing the list of the manuscripts recommended for the publication in the Conference Proceedings has been defined.The problem of assessment, prophylaxis and preserving human psychological health is of utmost importance today. Its relevance is determined, first, by the fact that both a person and his / her development as a healthy and autonomous personality represent a subject of a psychological research. Second, recent global transformations impose special requirements to the person seeking for health preservation, self-development, and self-actualisation. Among these requirements there is readiness to act in new, unpredictable conditions, to make decisions in unstable situations and to bear responsibility for one's decisions. To meet these requirements, a person should be able to see opportunities for self-development and self-fulfillment in the surrounding world, finding new meanings of his / her life activity.Existence of life resource and life potential expands the scope of any person's activities, turning the person's significant life purposes into more achievable ones. Resources are known to subjectively increase the value of a person both in his / her self-perception and in the eyes of others, making the person stronger, more prominent and proactive.Among various human resources health is a fundamental one. At the same time, life potential is not a less important characteristic, since it ensures human capacity to create, develop and use life conditions, factors and circumstances which are beneficial for an organism.Considering human health through the prism of life potential, it is necessary that the value of health within culture of its formation should be the highest, being defined not so much by the need for self-preservation but for self-improvement.The presented Proceedings are the result of both scientific studies in Psychology and fruitful and prospective long-term inte...

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“…Healthful eating patterns such as the Mediterranean diet, have been shown to offer protective effects on brain function, such as memory and cognitive processes (5,6). A growing number of data indicates that native Mediterranean herbs and spices are within those components of the Mediterranean diet involved in memory and cognitive enhancement (7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Natural Extracts Improved Cognitive Behavior in Zebrafish and Healthy Rats and Ameliorated LPS-induced Cognitive Impairment in a Sex Dependent Manner

Pusceddu¹,

Hernandez-Baixauli²,

Puiggrós³

et al. 2020

Preprint

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Background: Several findings suggest neuroinflammation as a contributing factor for the onset of psychiatric disorders such as Alzheimer’s disease, depression, and anxiety. There is increasing evidence pointing out that the Mediterranean diet influences brain and behavior. Mediterranean herbs and spices have been shown to be within those components of the Mediterranean diet involved in cognitive enhancement. Thus, we investigated the influence of Mediterranean natural extracts (MNE), Rosemary extract (RE) and Glycyrrhiza glabra root extract (GGRE), on cognitive behavior. Results: Adult zebrafish were exposed to RE or GGRE (100 and 250 mg/L) treatments. Both MNE improved memory retention during the T-maze test, although no improvements were observed during the novel object preference. Similarly, chronic administration of RE (150 mg/Kg) and GGRE (150 mg/Kg) improved, respectively, spatial and retention memory, as assessed by the Morris Water Maze (MWM), and the Elevated Plus Maze (EPM) in healthy male rats. However, no improvements were observed during the novel object recognition. Finally, male, and female rats were chronically treated with lipopolysaccharide [(LPS) 300 ug/kg] and orally administered with RE. Interestingly, RE reversed LPS-induced cognitive deficit during the MWM and EPM in female rats. Conclusions: We found that MNE improved cognition in both zebrafish and rats. Moreover, MNE rescued LPS-induced cognitive impairment in a gender-specific manner. Therefore, our study supports the view that zebrafish represent a valuable preclinical model for drug discovery in neuroscience. These findings contribute to an exciting and growing body of research suggesting that MNE may play an important role in the prevention of cognitive impairment.

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Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial

Cited by 20 publications

References 37 publications

Valerian extract alters functional brain connectivity: A randomized double‐blind placebo‐controlled trial

Valerian extract alters functional brain connectivity: A randomized double‐blind placebo‐controlled trial

Proceedings of the Iii International Scientific and Practical Conference “Psychological Health of the Person: Life Resource and Life Potential”

Mediterranean Natural Extracts Improved Cognitive Behavior in Zebrafish and Healthy Rats and Ameliorated LPS-induced Cognitive Impairment in a Sex Dependent Manner

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