Can vertebral density changes be explained by intervertebral disc degeneration?

Homminga, Jasper Johan; Aquarius, René; Bulsink, Vera Elisabeth; Jansen, Corine

doi:10.1016/j.medengphy.2011.08.003

Cited by 42 publications

(42 citation statements)

References 34 publications

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“…Similar results were reported by Adams et al [32]. Finally, Homminga et al [33] have demonstrated that complete disc degeneration leads to a great reduction of apparent density in the vertebral core.…”

Section: Discussionsupporting

confidence: 81%

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

et al. 2016

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Spinal osteoarthritis has been suggested as a risk factor for vertebral fractures. However, results are conflicting: most of the data are focused on the lumbar region, and referred to postmenopausal women, whereas data for men are scarce. The aim of this study is to assess the relationship between spinal osteoarthritis and vertebral fractures in men over 50 years of age. We conducted a cross-sectional study, nested in a prospective population-based cohort, including 507 community-dwelling men, 93 of them with at least one vertebral fracture. Vertebral fractures, osteophytosis, and disc space narrowing (DSN) were assessed by lateral thoracic and lumbar radiographs. Anthropometric, clinical, and densitometric variables were also analyzed. A multiple logistic regression model was performed. Eighty-five percent of vertebral fractures were located at the thoracic spine. Osteophytosis and DSN showed a bimodal distribution, with major frequency peaks at mid- and distal lumbar spine. The three distributions overlapped around the T9 vertebra. We did not find any relationship between lumbar osteoarthritis and vertebral fractures. Nevertheless, thoracic osteophytosis (OR, 1.84; 95 % CI, 1.05-3.17; p = 0.03) and DSN (OR, 2.52; 95 % CI, 1.43-4.46; p = 0.001) were found to be independently associated with prevalent vertebral fractures, after adjusting for confounders. Our results suggest a positive relationship between radiologic osteoarthritic changes at the thoracic spine and prevalent vertebral fractures in men more than 50 years of age. Osteoarthritis may act as a local risk factor, in addition to other mechanical factors, resulting in a greater propensity to fracture, especially at the mid-thoracic region.

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Section: Discussionsupporting

confidence: 81%

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

et al. 2016

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“…Several authors studied the effects of boundary conditions during loading (Homminga et al 2004, Eswaran et al 2006, Fields et al 2010, Homminga et al 2011) using computationally expensive linear elastic µFE models. They did not attempt to compute the ultimate force, keystone of fracture risk prediction from FE , Buckley et al 2007, Chevalier et al 2008, nor did they quantify damage in the bone.…”

Section: Discussionmentioning

confidence: 99%

“…The force-deflection curves highlight the effects of the boundary condition on ultimate force: the stiffness of the embedding material compared to the relative softness of the healthy intervertebral disc affects the way the endplates distribute stress in the vertebral body and the overall ductility of the vertebral bodies (Nekkanty et al 2010). Indeed, in vitro (Shirado et al 1992 andDai 1998) and FE (Homminga et al 2001, Polikeit et al 2004) studies reports less risk of fracture for an osteoporotic vertebral body when surrounded by degenerated discs: the trabecular bone acting as an energy absorber carries a higher fraction of the load than the cortical shell when the vertebra is surrounded by healthy discs, while this fraction is lower in case of a stiff degenerated disc (Kurowski and Kubo 1986, Homminga et al 2001, Homminga et al 2011. The underestimation of our FE predictions compared to experimental data is explained by the non-viscous nature of our constitutive law for bone.…”

Section: Discussionmentioning

confidence: 99%

“…The meshing of the IVD using tetrahedral elements was therefore easier and contact between bone and IVD during the simulations was no longer necessary thanks to the perfect bonding between the meshes. The dimensions of the intervertebral disc are usually taken from measurements (Schroeder et al 2006, Shirazi-Adl et al 2010), MRI (Périé et al 2001 or QCT data (Ayturk et al 2010, Moramarco et al 2010, Homminga et al 2011) assuming the volume of the nucleus and its positioning within the disc (Jones and Wilcox 2008). Thus, a height of 5 mm was used for the two half-intervertebral discs (Amonoo-Kuofi 1991, Inoue et al 1999) and a volumetric ratio of 42% between nucleus pulposus and annulus fibrosus chosen (Goto et al 2002, Moramarco et al 2010.…”

Section: Mesh Generationmentioning

confidence: 99%

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Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compression

Maquer

Schwiedrzik

Zysset

2012

Computer Methods in Biomechanics and Biomedical Engineering

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Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compressionComputer tomography (CT-) based finite element (FE) models of vertebral bodies assess fracture load in vitro better than DXA, but boundary conditions affect stress distribution under the endplates that may influence ultimate load and damage localization under postyield strains. Therefore, HRpQCT-based homogenized FE models of 12 vertebral bodies were subjected to axial compression with two distinct boundary conditions: embedding in polymethylmethalcrylate (PMMA) and bonding to a healthy intervertebral disc (IVD) with distinct hyperelastic properties for nucleus and annulus. Bone volume fraction and fabric assessed from HRpQCT data were used to determine the elastic, plastic and damage behaviour of bone. Ultimate forces obtained with PMMA were 22% higher than with IVD but correlated highly (R 2 =0.99). At ultimate force, distinct fractions of damage were computed in the endplates (PMMA: 6%, IVD: 70%), cortex and trabecular subregions, which confirms previous observations that in contrast to PMMA embedding, failure initiated underneath the nuclei in healthy IVDs. In conclusion, axial loading of vertebral bodies via PMMA embedding versus healthy IVD overestimates ultimate load and leads to distinct damage localization and failure pattern.

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“…Paper [15] proves that implantation of an artificial disc gives stress patterns similar to those caused by the degenerated disc [16], so it can even deepen this effect. The results of the proposed model for the site-dependent stimulator (Fig.…”

Section: Discussionmentioning

confidence: 86%

Bone Remodelling Model Incorporating Both Shape and Internal Structure Changes by Three Different Reconstruction Mechanisms. A Lumbar Spine Case

Wymysłowski

Zagrajek

2016

Archive of Mechanical Engineering

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The paper presents a method of analysis of bone remodelling in the vicinity of implants. The authors aimed at building a model and numerical procedures which may be used as a tool in the prosthesis design process. The model proposed by the authors is based on the theory of adaptive elasticity and the lazy zone concept. It takes into consideration not only changes of the internal structure of the tissue (described by apparent density) but also surface remodelling and changes caused by the effects revealing some features of "creep". Finite element analysis of a lumbar spinal segment with an artificial intervertebral disc was performed by means of the Ansys system with custom APDL code. The algorithms were in two variants: the so-called siteindependent and site-specific. Resultant density distribution and modified shape of the vertebra are compared for both of them. It is shown that this two approaches predict the bone remodelling in different ways. A comparison with available clinical outcomes is also presented and similarities to the numerical results are pointed out.

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Can vertebral density changes be explained by intervertebral disc degeneration?

Cited by 42 publications

References 34 publications

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compression

Bone Remodelling Model Incorporating Both Shape and Internal Structure Changes by Three Different Reconstruction Mechanisms. A Lumbar Spine Case

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