Can We Estimate Quality of Life in Pediatric Inflammatory Bowel Disease Patients? An Asian Multicenter Study

Kim, Seung; Park, Sowon; Kang, Yunkoo; Kim, Jung Eun; Kang, Ben; Choe, Byung-Ho; Lee, Yeoun Joo; Park, Jae Hong; Yang, Hye Ran; Lee, Sung Hee; Kim, Kyung Mo; Ryoo, Eell; Tchah, Hann; Shim, Jung Ok; Koh, Hong

doi:10.1097/mpg.0000000000002119

Cited by 15 publications

(24 citation statements)

References 31 publications

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“…One of the major findings of our study is the negative association of female gender with most of the domains scores (Bowel Symptoms, Emotional Functioning, Systemic Symptoms and Treatment/Intervention) and with the total IMPACT-III score. While a similar effect has been well described in adult studies 19 – 21 , pediatric data are less consistent 22 , 23 . Previous studies reported a lower score in the “body image domain” for females which might be correlated with impaired QOL, a finding that is not confirmed by our study.…”

Section: Discussionsupporting

confidence: 57%

Factors associated with quality of life in Italian children and adolescents with IBD

Gatti

Baldo

Catassi

et al. 2021

Sci Rep

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Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, discriminant validity and reproducibility of the Italian version of the IMPACT-III questionnaire was measured in IBD children/adolescents in 8 centers. Associations between patient and disease characteristics and the IMPACT-III domains were analyzed through quantile regression analysis. The IMPACT-III questionnaire, collected in 282 children with IBD (median age: 14.8 years; IQR 12.4–16.4) showed a median total score of 76 (IQR 67–83). Female gender, active disease and age were negatively associated with the total IMPACT-III score. Specifically, female gender was negatively associated with the Bowel/Systemic Symptoms, Emotional and Treatment domain scores, while disease activity was significantly associated with Bowel Symptoms and Treatment/Interventions reported QoL. The IMPACT- III showed good internal consistency (Cronbach’s alpha coefficient = 0.87, 95% CI 0.85–0.89) and reproducibility (Concordance Correlation Coefficient = 0.66, 95% CI 0.57–0.74). In Italian children with IBD active disease, female gender and adolescence are associated to a worse QoL, indicating the need of more attention in this subgroup of young patients. IMPACT-III questionnaire is a reliable instrument to measure QoL in Italian children.

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Section: Discussionsupporting

confidence: 57%

Factors associated with quality of life in Italian children and adolescents with IBD

Gatti

Baldo

Catassi

et al. 2021

Sci Rep

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“…[12] Early diagnosis of IBD leads to timely management and better outcomes. Conversely, a delay in the diagnosis is associated with delayed therapy resulting in continued disease activity which not only results in prolonged suffering that affects the quality of life,[34] but also complications requiring early surgery. [56] Most of the literature on risk factors and health consequences of long diagnostic delays of IBD are about adults and Western populations.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia

Mouzan¹,

AlSaleem²,

Hasosah³

et al. 2019

Saudi J Gastroenterol

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Background/Aim: Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children. Patients and Methods: This was a multicenter study with a retrospective/prospective design. Data on diagnostic delay in children with Crohn's disease (CD) and ulcerative colitis (UC) were retrieved from physician's notes. Multivariate regression analysis was used to assess the risk factors associated with long delay in diagnosis. Results: There were 240 and 183 Saudi children with CD and UC, respectively. The median delays in diagnosis were 8 and 5 months in CD and UC, respectively, significantly longer in children with CD than UC ( P < 0.001). Long diagnostic delays (>75 th percentile) were 24 and 8.8 months for CD and UC, respectively. Ileal location was a significant risk factor in CD and the age of onset above 10 years was protective in UC. Conclusions: Long diagnostic delay in IBD was mainly due to the longer delay in gastroenterologist consultation. Review of the referral system is needed to focus on measures to reduce long delays in diagnosis. The ileal location as a risk factor in CD and age older than 10 years as protective in UC should help recognition and early referral.

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“…This further confirms the findings of previously published study. 7,23,24 In our study, almost half (49.3%) of the families come from poor socio-economic background, and Malaysia is a lower-middle income country, in contrast with Italy which is a high-income country. Generally, lower socio-economic status is associated with lower HRQoL in IBD.…”

Section: Discussionmentioning

confidence: 57%

Quality of life in Malaysian children with inflammatory bowel disease: An understudied population

Lee

Chew

Wong

et al. 2022

J Paediatrics Child Health

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Aim Quality of life (QoL) in children with inflammatory bowel disease (IBD) is often impaired by underlying disease. We evaluated factors affecting health‐related QoL (HRQoL) in Malaysian children with IBD. Methods A cross‐sectional study using IMPACT‐III questionnaires evaluating HRQoL in children aged 8–17 years with duration of IBD of ≥6 months was conducted. IMPACT‐III, a validated instrument designed to measure HRQoL in children with IBD, was used. Higher IMPACT‐III (maximum = 100) score indicates better HRQoL. Impact of socio‐demographic and clinical factors of IBD on the HRQoL was evaluated. Paediatric Crohn's disease (CD) and ulcerative colitis (UC) activity indices were used to classify disease severity. Results A total of 75 children (UC = 44, CD = 41; mean (SD) age at diagnosis 8.2 (3.5) years) were interviewed at mean age of 12.8 (2.7) years. Mean IMPACT‐III score was significantly lower in children with more severe disease (mild: 71.8 (13.6) vs. moderate: 65.5 (10.9) vs. severe: 46.3 (14.5); P < 0.001), history of hospitalisation (yes: 64.0 (14.0) vs. none: 74.1 (12.2), P = 0.034) and a higher number of admissions (r = −0.352, P = 0.041) in preceding 6 months. Diagnosis at a younger age (r = −0.31, P = 0.007) and a longer duration of disease (r = 0.286, P = 0.013) was associated with higher score. A higher weight‐for‐age (r = 0.261, P = 0.023) or body mass index‐for‐age z‐score (r = 0.235, P = 0.042) was correlated with a better body image domain score, respectively. Conclusions In Malaysian children with IBD, HRQoL was adversely affected by a more severe disease. Better control of disease activity and maintaining long‐term remission are important to improve the HRQoL in childhood IBD.

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Can We Estimate Quality of Life in Pediatric Inflammatory Bowel Disease Patients? An Asian Multicenter Study

Abstract: Various clinical factors may affect the QoL in patients with IBD, but determining the overall QoL of patients using only these clinical factors is difficult. Therefore, regular direct measurements of QoL are necessary to better understand patients with IBD.

Cited by 15 publications

References 31 publications

Factors associated with quality of life in Italian children and adolescents with IBD

Factors associated with quality of life in Italian children and adolescents with IBD

Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia

Quality of life in Malaysian children with inflammatory bowel disease: An understudied population

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