Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

Alvira, Cristina M.; Morty, Rory E.

doi:10.1016/j.jpeds.2017.08.041

Cited by 50 publications

(37 citation statements)

References 209 publications

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“…Second, SGA and PDA are well‐known unique risk factors for BPD . In the present study both factors were not significantly associated with the chest radiograph classification.…”

Section: Discussioncontrasting

confidence: 62%

“…also reported an association between the cystic/bubbly pattern and intrauterine inflammation, as well as an association between bubbly/cystic appearance on chest radiograph and obstructive lung disease in school‐age children . Whether CAM is associated with the risk factors for BPD, however, remains debatable …”

Section: Discussionmentioning

confidence: 99%

“…7 Whether CAM is associated with the risk factors for BPD, however, remains debatable. 15,16 Second, SGA and PDA are well-known unique risk factors for BPD. 4,15,17 In the present study both factors were not significantly associated with the chest radiograph classification.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Second, SGA and PDA are well-known unique risk factors for BPD. 4,15,17 In the present study both factors were not significantly associated with the chest radiograph classification. Although the differences remain to be clarified, it is suggested that the BPD definition be based on the pathophysiology (chest radiograph classification) or be defined according to the treatment, such as oxygen and/or positive pressure ventilation dependency (BPD36 definition).…”

Section: Discussionmentioning

confidence: 99%

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Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Arai

Ito

et al. 2019

Pediatrics International

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Background Bubbly/cystic appearance on chest radiograph is an important factor in severe‐type bronchopulmonary dysplasia (BPD) in Japan. The aim of this study was to determine the perinatal characteristics and neonatal complications of the bubbly/cystic(+) group in extremely preterm infants with BPD, that is, oxygen dependency at day 28 after birth (BPD28). Methods This was a multicenter retrospective cohort study of population data from infants (birthweight, <1,500 g) enrolled in the Neonatal Research Network of Japan. Of the 15 480 infants born at <28 weeks’ gestational age (GA) between 2003 and 2012, 8,979 met the BPD28 criteria. The BPD28 infants were classified according to bubbly/cystic appearance on radiograph (±) at >28 postnatal days. Results The bubbly/cystic(+) group had lower GA and birthweight and required longer mechanical ventilation and oxygen dependency than the bubbly/cystic(−) group. After adjustment for confounding factors, bubbly/cystic appearance was an independent risk factor for home oxygen therapy at discharge. Conclusion Bubbly/cystic appearance on chest radiograph was a predictor of short‐term respiratory outcomes in infants with BPD28, which is diagnosed much earlier (≥28 postnatal days), and has a potentially different etiology to BPD36 (oxygen and/or positive pressure respiratory support dependency at 36 weeks’ postmenstrual age).

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“…Second, SGA and PDA are well‐known unique risk factors for BPD . In the present study both factors were not significantly associated with the chest radiograph classification.…”

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Arai

Ito

et al. 2019

Pediatrics International

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“…The differences they observed in the responses highlight the caution needed when interpreting results using a single congenic strain in disease models. As the authors note in their discussion, the model systems are adjusted to yield a particular morphologic phenotype to best mimic the disease state in question, as recently reviewed in detail by the senior author . Although the high F i O 2 used by Tiono et al would not be common among patients who develop BPD, it is necessary to produce the interruption in murine alveolarization that is believed to be part of the so‐called “new BPD.”…”

mentioning

confidence: 99%

Strain matters: Murine models of BPD

Auten

2019

Pediatric Pulmonology

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Mouse models of disease have achieved their prominence in part because of the relatively low costs of housing the species and the wide availability of genetically altered strains that can yield mechanistic insights. In this issue, Tiono et al 1 report a comparison of mouse-strain susceptibility to neonatal hyperoxia exposure. The differences they observed in the responses highlight the caution needed when interpreting results using a single congenic strain in

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Mouse genetic background impacts susceptibility to hyperoxia‐driven perturbations to lung maturation

Tiono

Solaligue

Mižíková

et al. 2019

Pediatric Pulmonology

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Background: The laboratory mouse is widely used in preclinical models of bronchopulmonary dysplasia, where lung alveolarization is stunted by exposure of pups to hyperoxia. Whether the diverse genetic backgrounds of different inbred mouse strains impacts lung development in newborn mice exposed to hyperoxia has not been systematically assessed.Methods: Hyperoxia (85% O 2 , 14 days)-induced perturbations to lung alveolarization were assessed by design-based stereology in C57BL/6J, BALB/cJ, FVB/NJ, C3H/HeJ, and DBA/2J inbred mouse strains. The expression of components of the lung antioxidant machinery was assessed by real-time reverse transcriptase polymerase chain reaction and immunoblot.Results: Hyperoxia-reduced lung alveolar density in all five mouse strains to different degrees (C57BL/6J, 64.8%; FVB/NJ, 47.4%; BALB/cJ, 46.4%; DBA/2J, 45.9%; and C3H/HeJ, 35.9%). Hyperoxia caused a 94.5% increase in mean linear intercept in the C57BL/6J strain, whilst the C3H/HeJ strain was the least affected (31.6% increase).In contrast, hyperoxia caused a 65.4% increase in septal thickness in the FVB/NJ strain, where the C57BL/6J strain was the least affected (30.3% increase). The expression of components of the lung antioxidant machinery in response to hyperoxia was strain dependent, with the C57BL/6J strain exhibiting the most dramatic engagement. Baseline expression levels of components of the lung antioxidant systems were different in the five mouse strains studied, under both normoxic and hyperoxic conditions. Conclusion: The genetic background of laboratory mouse strains dramatically influenced the response of the developing lung to hyperoxic insult. This might be explained, at least in part, by differences in how antioxidant systems are engaged by different mouse strains after hyperoxia exposure. K E Y W O R D S alveolarization, bronchopulmonary dysplasia, hyperoxia, strain

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Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

Cited by 50 publications

References 209 publications

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Strain matters: Murine models of BPD

Mouse genetic background impacts susceptibility to hyperoxia‐driven perturbations to lung maturation

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