Can we use electrocochleography as a clinical tool in the diagnosis of Meniere’s disease during the early symptomatic period?

Oh, Kyoung Ho; Kim, Kang Woo; Chang, Jiwon; Jun, Hyun Su; Kwon, Eun Ha; Choi, Jeong Yoon; Im, Gi Jung; Chae, Sung Won; Jung, Hak Hyun; Choi, June

doi:10.3109/00016489.2014.907500

Cited by 14 publications

(9 citation statements)

References 20 publications

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“…The concomitant increase in SP amplitude and decrease in AP amplitude can be attributed for the statistically significant increase in SP/AP amplitude ratios and SP/AP area ratios with an increase in stimulus rate from 7.7 to 77.7/sec. SP amplitude, AP latency, AP amplitude, SP/AP amplitude ratio, and SP/AP area ratio are generally similar to those reported in the literature for extratympanic (Coats, 1981;Oh et al, 2014) and tympanic (Margolis et al, 1992;Ferraro and Tibbils, 1999;Grasel et al, 2017) electrode placements. Variability across measures was also similar for extratympanic (Roland et al, 1993) and tympanic (Park and Ferraro, 1999) electrode placements.…”

Section: Discussionsupporting

confidence: 86%

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The Effect of Test, Electrode, and Rate on Electrocochleography Measures

Lake

Stuart

2019

J Am Acad Audiol

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Electrocochleography (ECochG) is the measurement of stimulus-related cochlear potentials and the compound action potential (AP). Its primary clinical application is with the assessment of inner ear disorders. There are few studies examining the variability of ECochG measures.The objective of the study was to examine the effect of test (i.e., initial versus retest), electrode (i.e., extratympanic versus tympanic), and stimulus rate (i.e., 7.7 versus 77.7/sec) on ECochG indices (i.e., summating potential [SP] amplitude, AP latency, AP amplitude, SP/AP amplitude ratio, and SP/AP area ratio).Correlational and three-factor repeated measures designs were employed.Eighteen normal-hearing young adults participated.ECochG responses were obtained with 90 dB nHL click stimuli for an initial test and retest at two stimulus rates with a commercially available extratympanic (TIPtrode™) and tympanic (Lilly TM-Wick) electrode. Separate repeated measures linear mixed-model analysis of variance examined the effect of test, electrode, and rate for all ECochG indices. Test–retest variability was also examined with correlation analyses; an examination of mean test–retest differences and their 95% confidence intervals (CI); and construction of Bland-Altman plots.The presence of SP and AP responses varied across experimental conditions. Electrode and rate were statistically significant predictors (p < 0.05) of SP and AP responses: SP and AP responses were more likely to be present with the tympanic electrode and at the slow rate. Statistically significant correlations (p < 0.05) were found between initial tests and retests with all ECochG indices with both electrodes with the exception of SP amplitude with the TIPtrode™ electrode. There were no significant main effects of test (initial versus retest) or interactions of test and electrode or rate for any of the ECochG indices (p > 0.05). The 95% CI of the mean test–retest differences contained 0 confirming that the effect of test was not statistically significant. There was a statistically significant main effect of electrode (p < 0.05) on three ECochG measures. The Lilly TM-Wick electrode produced larger SP amplitudes, AP amplitudes, and SP/AP area ratios than TIPtrode™ electrodes. A statistically significant main effect of rate (p < 0.05) was identified for all ECochG measures. The effect of rate on AP latency and amplitude was expected. Increasing the stimulus rate prolonged the AP latency and decreased AP amplitude. SP amplitude was larger for the faster rate.There was no difference between electrodes with regard to test–retest measures. However, considering the higher likelihood of ECochG SP and AP responses and larger SP amplitude, SP/AP amplitude ratio, and SP/AP area ratio indices, the tympanic electrode placement is recommended for clinical practice. The addition of a fast stimulus rate may be considered for enhanced SP amplitude, SP/AP amplitude ratio, and SP/AP area ratio albeit with the consideration of the loss of SP and AP responses in some individuals.

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Section: Discussionsupporting

confidence: 86%

“…Several researchers have reported the presence/ absence of ECochG components in large-scale normative studies. Oh et al (2014) used an extratympanic electrode while recording ECochGs in 30 normal adults ranging in age from 21 to 63 yr (M 5 43.5 yr). Details of the extratympanic electrode were not provided.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Test, Electrode, and Rate on Electrocochleography Measures

Lake

Stuart

2019

J Am Acad Audiol

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“…Moreover, even if vertigo attacks disappear completely after treatment, the SP/AP ratio does not recover (38). Besides that, ECoG is an informative test, in prediction of when the disease will be bilateral, decision of treatment choices, or renewal of the treatment method (6,36,37). The sensitivity of the ECoG test in the diagnosis of MD variants, vestibular MD (recurrent vestibulopathy) and cochlear MD (acute low tone sensorineural hearing loss), were reported to be 62.5% and 67%, respectively (39).…”

Section: Ecogmentioning

confidence: 99%

“…ECoG may not correlate with the stage of disease, duration of symptoms, patient history, and audiometric findings all the time (6,(36)(37)(38). Moreover, even if vertigo attacks disappear completely after treatment, the SP/AP ratio does not recover (38).…”

Section: Ecogmentioning

confidence: 99%

Validity and Reliability of the Diagnostic Tests for Ménière's Disease

Günerı

Çakır

Mutlu

2016

Turk Arch Otorhinolaryngol

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Ménière's disease is defined as an idiopathic syndrome characterized by endolymphatic hydrops. Various tests and measurement methods have been employed for the diagnosis of Ménière's disease. These include audiological, vestibular, radiological, clinical, and biochemical tests. However, the lack of a definitive or gold standard diagnostic test sometimes complicates the process of diagnosis. Hence, the clinician should be well-experienced in deciding when to perform a test and how to interpret the results of the test. Furthermore, having the knowledge of the validity and reliability of these tests plays a critical role. This review particularly emphasizes on remarking the validity and reliability of each test performed for the diagnosis of Ménière's disease and discussing the results according to the up-to-date literature.

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“…However, tone burst SP-amplitude measurements were found significantly different between the two groups, particularly for frequencies at 500 Hz, 1 kHz, and 2 kHz. Recently, Oh et al (2014) reported that: “Statistically significant differences were not demonstrated in the SP/AP amplitude ratio or SP area /AP area ratio between the definite Ménière’s, probable Ménière’s, overall Ménière’s, or control groups”. These less than positive findings were echoed by a questionnaire on the clinical utility of ECochG in the diagnosis of Ménière’s disease among members of the American Otological Society (AOS) and American Neurotology Society (ANS).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Ups and Downs in 75 Years of Electrocochleography

Eggermont

2017

Front. Syst. Neurosci.

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Before 1964, electrocochleography (ECochG) was a surgical procedure carried out in the operating theatre. Currently, the newest application is also an intra-operative one, often carried out in conjunction with cochlear implant surgery. Starting in 1967, the recording methods became either minimal- or not-invasive, i.e., trans-tympanic (TT) or extra tympanic (ET), and included extensive studies of the arguments pro and con. I will review several valuable applications of ECochG, from a historical point of view, but covering all 75 years if applicable. The main topics will be: (1) comparing human and animal cochlear electrophysiology; (2) the use in objective audiometry involving tone pip stimulation—currently mostly pre cochlear implantation but otherwise replaced by auditory brainstem response (ABR) recordings; (3) attempts to diagnose Ménière’s disease and the role of the summating potential (SP); (4) early use in diagnosing vestibular schwannomas—now taken over by ABR screening and MRI confirmation; (5) relating human electrophysiology to the effects of genes as in auditory neuropathy; and (6) intracochlear recording using the cochlear implant electrodes. The last two applications are the most recently added ones. The “historical aspects” of this review article will highlight the founding years prior to 1980 when relevant. A survey of articles on Pubmed shows several ups and downs in the clinical interest as reflected in the publication counts over the last 75 years.

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Can we use electrocochleography as a clinical tool in the diagnosis of Meniere’s disease during the early symptomatic period?

Cited by 14 publications

References 20 publications

The Effect of Test, Electrode, and Rate on Electrocochleography Measures

The Effect of Test, Electrode, and Rate on Electrocochleography Measures

Validity and Reliability of the Diagnostic Tests for Ménière's Disease

Ups and Downs in 75 Years of Electrocochleography

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