Can Zika virus antibodies cross-protect against dengue virus?

Ariën, Kevin K.; Míchiels, Johan; Foqué, Nikki; Heyndríckx, Leo; Esbroeck, Marjan Van

doi:10.1016/s2214-109x(18)30122-0

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…Contemporaneous studies from Brazil and Nicaragua demonstrated evidence of short-term protection from ZIKV infection or development of ZIKV disease associated with recent DENV infection [ 47 , 50 ]. Initial analyses demonstrated a low frequency of cross-neutralization following ZIKV infection, suggesting that ZIKV does not elicit long-lasting cross-protective antibodies against DENV [ 51 , 52 ]. Both protection from and enhancement of dengue severity has been associated with prior exposure to other flaviviruses [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico

et al. 2020

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Background After Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findings Suspected cases of arboviral disease reported to Puerto Rico Department of Health were tested for evidence of infection with Zika, dengue, and chikungunya viruses by RT-PCR and IgM ELISA. To describe spatiotemporal trends among confirmed ZIKV disease cases, we analyzed the relationship between municipality-level socio-demographic, climatic, and spatial factors, and both time to detection of the first ZIKV disease case and the midpoint of the outbreak. During November 2015-December 2016, a total of 71,618 suspected arboviral disease cases were reported, of which 39,717 (55.5%; 1.1 cases per 100 residents) tested positive for ZIKV infection. The epidemic peaked in August 2016, when 71.5% of arboviral disease cases reported weekly tested positive for ZIKV infection. Incidence of ZIKV disease was highest among 20-29-year-olds (1.6 cases per 100 residents), and most (62.3%) cases were female. The most frequently reported symptoms were rash (83.0%), headache (64.6%), and myalgia (63.3%). Few patients were hospitalized (1.2%), and 13 (<0.1%) died. Early detection of ZIKV disease cases was associated with increased population size (log hazard ratio [HR]:-0.22 [95% confidence interval-0.29,-0.14]), eastern longitude (log HR:-1.04 [-1.17,-0.91]), and proximity to a city (spline estimated degrees of freedom [edf] = 2.0). Earlier midpoints of the outbreak were associated with northern latitude (log HR:-0.30 [-0.32,-0.29]), eastern longitude (spline edf = 6.5), and higher mean monthly temperature PLOS NEGLECTED TROPICAL DISEASES

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Section: Discussionmentioning

confidence: 99%

Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico

et al. 2020

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“…A pattern also found in vivo when rhesus macaques, previously infected with ZIKV, experienced higher viremia and proinflammatory cytokines during a subsequent DENV-2 infection compared to those previously uninfected with ZIKV [ 17 ]. In contrast, a Brazilian study reported a decline in dengue infections following a Zika outbreak, eluding to cross-protection, not enhancement [ 18 ]. However, given that cross-protective ZIKV IgG antibodies wane over time [ 19 ], the remaining cross-reactive antibodies may facilitate adverse ADE mechanisms later in life.…”

Section: Introductionmentioning

confidence: 99%

Serological Evidence of Widespread Zika Transmission across the Philippines

Biggs

Brady

et al. 2021

Viruses

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Zika virus (ZIKV) exposure across flavivirus-endemic countries, including the Philippines, remains largely unknown despite sporadic case reporting and environmental suitability for transmission. Using laboratory surveillance data from 2016, 997 serum samples were randomly selected from suspected dengue (DENV) case reports across the Philippines and assayed for serological markers of short-term (IgM) and long-term (IgG) ZIKV exposure. Using mixture models, we re-evaluated ZIKV IgM/G seroprevalence thresholds and used catalytic models to quantify the force of infection (attack rate, AR) from age-accumulated ZIKV exposure. While we observed extensive ZIKV/DENV IgG cross-reactivity, not all individuals with active DENV presented with elevated ZIKV IgG, and a proportion of dengue-negative cases (DENV IgG-) were ZIKV IgG-positive (14.3%, 9/63). We identified evidence of long-term, yet not short-term, ZIKV exposure across Philippine regions (ZIKV IgG+: 31.5%, 314/997) which was geographically uncorrelated with DENV exposure. In contrast to the DENV AR (12.7% (95%CI: 9.1–17.4%)), the ZIKV AR was lower (5.7% (95%CI: 3–11%)) across the country. Our results provide evidence of widespread ZIKV exposure across the Philippines and suggest the need for studies to identify ZIKV infection risk factors over time to better prepare for potential future outbreaks.

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“…Despite this evidence from DENV sequential infections, it remains poorly understood if the same applies to the time interval between ZIKV–DENV sequential infections. So currently, the role of multiple convalescent periods to ZIKV in the outcome of DENV and other flavivirus infections is in the forefront of discussions based on the limited studies available in experimental models and a lack of characterized human prospective cohorts of this scenario yet 27,43–45 .…”

Section: Introductionmentioning

confidence: 99%

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

et al. 2019

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Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

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Can Zika virus antibodies cross-protect against dengue virus?

Cited by 8 publications

References 4 publications

Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico

Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico

Serological Evidence of Widespread Zika Transmission across the Philippines

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

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