Canadian high risk endometrial cancer (CHREC) consortium: Analyzing the clinical behavior of high risk endometrial cancers

Altman, Alon D.; Ferguson, Sarah E.; Atenafu, Eshetu G.; Köbel, Martin; McAlpine, Jessica N.; Panzarella, Tony; Lau, Susie; Gien, Lilian T.; Gilks, Blake; Clarke, Blaise A.; Cameron, A. T.; Nelson, Gregg; Han, Guangming; Samouëlian, Vanessa; Ho, T.C.; Louie, K.; Bernardini, Marcus Q.

doi:10.1016/j.ygyno.2015.09.001

Cited by 57 publications

(48 citation statements)

References 33 publications

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“…However, the diagnosis depends on intraoperative frozen section, a practice that has variable levels of reported accuracy [9,10] and may potentially lead to understaging some high-risk cases. In contrast, patients with high-grade histologies (endometrioid grade 3, clear cell, serous, and carcinosarcoma) have a 20–40% risk of lymph node involvement [8,11]. …”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Holloway

Abu‐Rustum

Backes

et al. 2017

Gynecologic Oncology

342

287

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The emphasis in contemporary medical oncology has been “precision” or “personalized” medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology’s (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document. Literature-based recommendations for the inclusion of SLN assessment in the treatment of patients with endometrial cancer are presented. This article examines: History and various techniques of SLN mapping in endometrial cancerPathology and clinical outcomes from SLN assessmentControversies and future directions for research in SLN assessment in endometrial cancer

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Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Holloway

Abu‐Rustum

Backes

et al. 2017

Gynecologic Oncology

342

287

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“…Uterine serous carcinoma patients have a high-risk to develop local and distant relapse [28], therefore it is essential to ensure an adequate treatment even if patients with an early stage disease. While prospective studies have demonstrated that the delivery of chemotherapy in combination with external beam radiation in an advanced stage disease may increase survival benefit and decreases local recurrences [29,30,31,32,33], the role of radiation in early stage USC has been more difficult to demonstrate.…”

Section: Discussionmentioning

confidence: 99%

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

Lancellotta

Felice

Vicenzi

et al. 2020

jcb

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Purpose: Serous adenocarcinoma (uterine serous carcinoma-USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT). Material and methods: A systematic research using PubMed, Scopus, and Cochrane library was conducted to identify full articles evaluating the efficacy of VBT in patients with stage I USC. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials, and in PROSPERO for searching ongoing or recently completed systematic reviews. Results: All studies were retrospective and 364 of evaluated patients were found. The average local control was 97.5% (range, 91-100%), the disease free-survival was 88% (range, 82-94%), the overall survival was 93% (range, 72-100%), the specific cancer survival was 89.4% (range, 84.8-94%), and the G3-G4 toxicity was 0-8%. Conclusions: These data support the concept that in adequately selected patients, VBT alone may be a suitable radiotherapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.

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“…Furthermore, since these reproducibility studies do not mirror usual pathology practice, reproducibility results are skewed and consequently exaggerated – for example, studies that used a single H&E slide for histotyping and did not include immunohistochemical slides. More importantly, if histotyping is truly irreproducible, why then did a large collaborative retrospective study find dramatic differences in the recurrence rate between stage IA grade 3 endometrioid and serous carcinomas ?…”

Section: Implementation or Integration Of Molecular Subclasses?mentioning

confidence: 99%

Letter in response to: McAlpine J, Leon‐Castillo A, Bosse T. The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses. J Pathol 2018; 244: 538–549

Köbel

Nelson

2018

The Journal of Pathology

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Implementation or integration of molecular subclasses? totyping. This assumption is based on the TCGA study, in which only cases of endometrioid histotype were classified into molecular subclasses [6]. Serous cases clustered in the 'copy number high' group and none of 13. Fadare O, Parkash V, Dupont WD, et al. The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features.

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Canadian high risk endometrial cancer (CHREC) consortium: Analyzing the clinical behavior of high risk endometrial cancers

Cited by 57 publications

References 33 publications

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

Letter in response to: McAlpine J, Leon‐Castillo A, Bosse T. The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses. J Pathol 2018; 244: 538–549

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