Canadian Society of Nephrology Commentary on the 2012 KDIGO Clinical Practice Guideline for Anemia in CKD

2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease

“…Note that the serum ferritin level should be measured at least 1 week after the last administration of iron because the level temporarily increases after the administration of iron [106]. In addition, iron therapy for CKD patients should be discontinued when the target Hb level is maintained or the patient has adequate iron stores, because unintentional iron administration to CKD patients may cause iron overload.…”

Total Red Blood Cell Transfusions for Chronic Hemodialysis Patients in a Single Center, 2009-2013

“…The Kidney Disease: Improving Global Outcomes guideline issued in 2012 [14] advised that ESAs be used when necessary to maintain Hb values >9.0 g/dl but <11.5 g/dl in CKD and ESRD patients. The Canadian Society of Nephrology [15] noted that an Hb range of 9.5-11.5 g/dl is probably acceptable.…”

Outcomes Associated with Conventional Accelerated Versus Once-Weekly IV Iron Therapy in Outpatients Undergoing Hemodialysis

“…1 The Kidney Disease Outcomes Quality Initiative (KDOQI) of the National Kidney Foundation, the Kidney Disease Improving Global Outcomes (KDIGO) initiative, and the Canadian Society of Nephrology (CSN) all recommend the use of IV iron and/or ESAs to achieve a hemoglobin level of 95 to 120 g/L (KDOQI target 110-120 g/L; KDIGO target 100-115 g/L; CSN target 100-110 g/L, with a range of 95-115 g/L) in patients undergoing hemodialysis. [1][2][3][4][5] Iron stores in the body are measured in terms of transferrin saturation (TSAT) and serum ferritin. The KDOQI and CSN guidelines recommend IV administration of iron to maintain serum ferritin between 200 and 500 μg/L and TSAT between 20% and 50% for patients undergoing hemodialy sis who require ESAs, 1,2 whereas the KDIGO guidelines suggest a trial of IV iron if TSAT is less than or equal to 30% and ferritin is less than or equal to 500 μg/L.…”