Canalicular Adenoma Arising in the Upper Lip: Review of the Pathological Findings

Abstract

This case report describes a rare case of canalicular adenoma arising in the upper lip of a 61-year-old male patient. Macroscopic examination of the tumor revealed a welldefined, smooth, firm, elastic hard, round nodule with a diameter of 1.0cm. The cut surface was white. Histopathology showed that the tumor was an encapsulated mass with a complex cellular pattern of anastomosing duct-like or trabecular structures lined by a single layer of tall columnar epithelial cells, which were embedded in a loose, fibrous, and highly vascular connective tissue stroma. The tumor cells were immunoreactive to AE1/AE3, CK19 and S-100, were partially positive for CK7, CK8, GFAP and PCNA, but were negative for SMA, CK13, CK14 and vimentin.

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

“…The histologic differential diagnosis encompasses primarily salivary gland neoplasms, including basal cell adenoma, pleomorphic adenoma (PA), PLGA, adenoid cystic carcinoma (ACC), ductal adenoma, and reticulated myoepithelioma, while ameloblastoma, adenomatoid odontogenic tumor, paraganglioma, and skin basal cell carcinoma are also occasionally considered [16,21,25,32,88,107].…”

Quiz Correct answer to the quiz. Check your diagnosis Canalicular adenoma of the upper lip Metachronous (multifocal) canalicular adenoma of the upper lip: a of an unusual finding

“…These cells may be distributed in various arrangements as solid, trabecular, tubular and membranous [21]. In contrast, canalicular adenoma is char-DARIUSZ TYRALIK, ANETA DZIERWA-GAWRON, JANUSZ RYŚ acterized by a complex cellular pattern of anastomosing duct-like, trabecular or papillary-like structures lined by a single layer of tall columnar epithelial cells embedded in a loose, fibrous, and highly vascular connective tissue stroma [21][22][23]. What is more, the results of several immunohistochemical studies showed a distinct immunoprofile for both neoplasms [21].…”

“…The cells of the canalicular adenoma showed an immunohistochemical profile that indicates an excretory duct origin: most of these cells were immunoreactive to pancytokeratins (AE1/AE3), and S-100 protein, but were negative for smooth muscle actin (SMA), vimentin and CK13 or CK14 [23][24][25]. Rare focal staining with antiepithelial membrane antigen was also noted [25].…”

Adenoma canalicular multifocal del labio superior: reporte de un caso y revisión de la literatura

“…En la histopatología, se observan cordones de doble fila de células columnares o cúbicas con patrón alternante descrito como "collar de perlas" (beading): los cordones se disponen paralelamente en contacto estrecho y posteriormente se separan formando estructuras similares a ductos que dan origen al término "canalicular" de este tumor (1,3,4,(5)(6)(7)(8)(9)(11)(12)(13)(14). Estas estructuras similares a ductos, pueden dilatarse y llegar a conformar quistes con formaciones papilares (1,5,11).…”