We study locally flat, compact, oriented surfaces in 4-manifolds whose exteriors have infinite cyclic fundamental group. We give algebraic topological criteria for two such surfaces, with the same genus g, to be related by an ambient homeomorphism, and further criteria that imply they are ambiently isotopic. Along the way, we prove that certain pairs of topological 4-manifolds with infinite cyclic fundamental group, homeomorphic boundaries, and equivalent equivariant intersection forms, are homeomorphic.