Cancer: an old disease, a new disease or something in between?

David, A. Rosalie; Zimmerman, Michael J.

doi:10.1038/nrc2914

Cited by 176 publications

(115 citation statements)

References 22 publications

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“…However, they unveil an unsuspected biological activity of this element that, similar to activated oncogenes transfected into primary cells (Collado and Serrano, 2010), increases DSBs and senescence in normal human mammary epithelial cell models (this study). This effect raises concerns about the wide use of aluminium in underarm cosmetics, and together with the aluminium's lack of mutagenic or transforming effect in bacteria, HaCaT keratinocytes or fibroblasts, contributes to the recent questioning on the choice of appropriate models for risk assessment of chemicals (Hunt, 2011;David and Zimmerman, 2010) in specific cell types or organisms.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, current procedures of chemical testing and risk assessment have recently been questioned (Hunt, 2011;David and Zimmerman, 2010). In MCF-7 human breast cancer cells, aluminium has been reported to interfere with the binding of estradiol to estrogen receptor (ER) and to enhance transcription from an estrogen-responsive element in a reporter system, thus suggesting that aluminium is a metalloestrogen (Darbre, 2005(Darbre, , 2006.…”

Section: Introductionmentioning

confidence: 99%

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Aluminium chloride promotes anchorage‐independent growth in human mammary epithelial cells

Sappino

Buser

Lesne

et al. 2012

J of Applied Toxicology

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Aluminium salts used as antiperspirants have been incriminated as contributing to breast cancer incidence in Western societies. To date, very little or no epidemiological or experimental data confirm or infirm this hypothesis. We report here that in MCF-10A human mammary epithelial cells, a well-established normal human mammary epithelial cell model, long-term exposure to aluminium chloride (AlCl 3 ) concentrations of 10-300 mM, i.e. up to 100 000-fold lower than those found in antiperspirants, and in the range of those recently measured in the human breast, results in loss of contact inhibition and anchorage-independent growth. These effects were preceded by an increase of DNA synthesis, DNA double strand breaks (DSBs), and senescence in proliferating cultures. AlCl 3 also induced DSBs and senescence in proliferating primary human mammary epithelial cells. In contrast, it had no similar effects on human keratinocytes or fibroblasts, and was not detectably mutagenic in bacteria. MCF-10A cells morphologically transformed by long-term exposure to AlCl 3 display strong upregulation of the p53/p21Waf1 pathway, a key mediator of growth arrest and senescence. These results suggest that aluminium is not generically mutagenic, but similar to an activated oncogene, it induces proliferation stress, DSBs and senescence in normal mammary epithelial cells; and that long-term exposure to AlCl 3 generates and selects for cells able to bypass p53/p21 Waf1 -mediated cellular senescence. Our observations do not formally identify aluminium as a breast carcinogen, but challenge the safety ascribed to its widespread use in underarm cosmetics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aluminium chloride promotes anchorage‐independent growth in human mammary epithelial cells

Sappino

Buser

Lesne

et al. 2012

J of Applied Toxicology

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“…Existe controversia sobre si las lesiones óseas prehistóricas son realmente consecuencia del cáncer o corresponden a otras etiologías (3,4) .…”

Section: El Cáncer En La Prehistoria Y Las Civilizaciones Extintasunclassified

La etimología del cáncer y su curioso curso histórico

Salaverry

2014

Rev Peru Med Exp Salud Publica

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RESUMENSe discuten las primeras descripciones de cáncer en la historia de acuerdo a recientes hallazgos y sus interpretaciones que lo muestra como un grupo de enfermedades raras hasta el siglo XVIII, cuando comenzó su incremento hasta los niveles actuales. La literatura médica muestra numerosos antecedentes de supuestas lesiones cancerosas que, en realidad, corresponden a otras lesiones. Parte de la explicación se refiere a un malentendido etimológico acerca de la palabra griega karkinos que significaba cáncer, en su sentido moderno, pero también lesión ulcerosa. Se revisa ampliamente esta confusión en la antigua literatura médica y luego se esbozan los principales hitos de la concepción moderna del cáncer hasta el siglo dieciocho.Palabras clave: Etimología; Cáncer; Úlcera; Historia de la medicina (fuente: DeCS BIREME). CANCER ETYMOLOGY AND ITS HISTORICAL CURIOUS COURSE ABSTRACTThe first cancer descriptions in history are discussed according to recent findings and their interpretation, which show it as a group of unknown diseases until the 18th century, when it started to increase to actual levels. Medical literature shows a variety of what were considered cancer lesions, which are actually different lesions. This is partly due to an etymological misunderstanding of the Greek term karkinos that, in its modern sense, meant "cancer", but also ulcerative lesion. This confusion is widely reviewed in the ancient medical literature and the main landmarks of modern cancer conception up to the 18th century are outlined.

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“…4,5 Segundo a Organização Mundial da Saúde (OMS), o câncer é a segunda maior causa de mortalidade em todo mundo, atrás apenas das doenças de origem cardiovascular.…”

Section: Introductionunclassified

Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA

Silva¹,

Donnici²,

Lopes³

et al. 2012

Quím. Nova

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Recebido em 12/7/11; aceito em 24/2/12; publicado na web em 15/6/12 ELECTROCHEMICAL AND CALORIMETRIC INVESTIGATION OF INTERACTION OF NOVEL BISCATIONIC ANTICANCER AGENTS WITH DNA. Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully characterized, and their interaction with DNA was also investigated. Isothermal titration calorimetry (ITC) was used to measure the thermodynamic properties of binding interactions between DNA and these ligands. A double stranded calf thymus DNA immobilized on an electrode surface was used to study the possible DNA-interacting abilities of these compounds towards dsDNA in situ. A remarkable interaction of these compounds with DNA was demonstrated and their potential application as anticancer agents was furthered.Keywords: biscationic compounds and interaction with DNA; isothermal titration calorimetry; electrochemical biosensor. INTRODUÇÃOO câncer é uma das doenças que mais causam temor na sociedade, por ter se tornado estigma de mortalidade e dor.1-3 Na verdade, a palavra câncer refere-se ao termo neoplasia, especificamente aos tumores malignos, doença caracterizada pelo crescimento descontrolado de células transformadas; 1 o termo câncer é utilizado genericamente para representar um conjunto de mais de 100 doenças.1,2 Na verdade, quase todos os organismos multicelulares podem ser afetados pelo câncer, inclusive lesões cancerosas foram encontradas em fósseis de dinossauros e em múmias do Egito Antigo. 4,5 Segundo a Organização Mundial da Saúde (OMS), o câncer é a segunda maior causa de mortalidade em todo mundo, atrás apenas das doenças de origem cardiovascular.6 Em 2008, a Agência Internacional para Pesquisa em Câncer (IARC/OMS) estimou que ocorreram 12,4 milhões de casos novos e 7,6 milhões de óbitos por câncer no mundo, e a OMS prevê que 84 milhões de pessoas devem morrer de câncer entre 2005 e 2015.7 Cerca de 1,5 milhão de casos de câncer são diagnosticados anualmente só nos EUA, e os médicos e pesquisadores do país estão engajados numa "guerra contra o câncer". 6,7 No Brasil, o câncer apresenta-se como a segunda maior causa de morte nos últimos anos; as estimativas do Instituto Nacional de Câncer (INCA) apontam que, até o final de 2008, ocorreram mais de 470 mil novos casos de câncer, número maior do que o de pessoas infectadas pelo vírus da AIDS nos últimos 25 anos, por exemplo. As estimativas para 2010 são válidas, também, para 2011 e apontam a ocorrência de 489.270 novos casos de câncer. Os tipos mais incidentes de câncer, à exceção do câncer de pele do tipo não melanoma, serão os de próstata e de pulmão, no sexo masculino, e os de mama e colo do útero, no sexo feminino. 1,8 Embora nenhum medicamento ou tratamento definitivo contra o câncer tenha ainda sido encontrado, tem-se obtido grande progresso na compreensão das causas do câncer, no desenvolvimento de tratamentos efetivos e de ...

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Cancer: an old disease, a new disease or something in between?

Cited by 176 publications

References 22 publications

Aluminium chloride promotes anchorage‐independent growth in human mammary epithelial cells

Aluminium chloride promotes anchorage‐independent growth in human mammary epithelial cells

La etimología del cáncer y su curioso curso histórico

Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA

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