Cancer and „cancer related”︁ colorectal lesions in São Paulo, Brazil

Marigo, Carlos; Correa, Pelayo; Haenszel, William

doi:10.1002/ijc.2910220602

Cited by 16 publications

(5 citation statements)

References 33 publications

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“…Of 8440 patients included in 16 studies, 1147 (13.6%) had 1 or more serrated polyps ( Supplementary Table 3). [83][84][85][86][87][88][89][90][91][92][93][94][95][96] There was a large geographic variation in the prevalence of serrated polyps, with high prevalence in the United Kingdom 90,91 New Zealand, 95 and the United States, 94 and very low prevalence in Singapore and Japan ( Figure 4A). 84,85,93 There were also large within-country differences related to urbanization (in Norway and Columbia).…”

Section: Prevalence Based On Autopsy Datamentioning

confidence: 99%

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

2019

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In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via the serrated pathway. Studies have focused on clarification of categories and molecular features of serrated polyps, as well as endoscopic detection and risk assessment. Guidelines from the World Health Organization propose assigning serrated polyps to categories of hyperplastic polyps, traditional serrated adenomas, and sessile serrated lesions (SSLs). Traditional serrated adenomas and SSLs are precursors to colorectal cancer. The serrated pathway is characterized by mutations in RAS and RAF, disruptions to the Wnt signaling pathway, and widespread methylation of CpG islands. Epidemiology studies of serrated polyps have been hampered by inconsistencies in terminology and reporting, but the prevalence of serrated class polyps is 20%-40% in average-risk individuals; most serrated polyps detected are hyperplastic. SSLs, the most common premalignant serrated subtype, and are found in up to 15% of average-risk patients by highdetecting endoscopists. Variations in rate of endoscopic detection of serrated polyps indicate the need for careful examination, with adequate bowel preparation and sufficient withdrawal times. Risk factors for SSLs include white race, family history of colorectal cancer, smoking, and alcohol intake. Patients with serrated polyps, particularly SSLs and traditional serrated adenomas, have an increased risk of synchronous and metachronous advanced neoplasia. Surveillance guidelines vary among countries, but SSLs and proximal hyperplastic polyps require special attention in assignment of surveillance interval-especially in light of concerns regarding incomplete detection and resection.

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Section: Prevalence Based On Autopsy Datamentioning

confidence: 99%

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

2019

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“…The frequent coexistence of diverticula and neoplastic lesions in the colon was reported several years ago in autoptic, radiologic, and endoscopic studies. 1,[23][24][25] However, such coexistence was considered, at that time, purely accidental, not deserving further clarification. 16,26 More recently, a few studies discovered an association between diverticulosis and CRC, opening the debate for a possible relationship in the pathogenesis of the 2 disorders.…”

Section: Diverticulosis and Crcmentioning

confidence: 99%

Diverticulosis and Colorectal Cancer

Morini

Zullo

Hassan

et al. 2008

Journal of Clinical Gastroenterology

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The prevalence of diverticulosis and colorectal cancer (CRC) is markedly increased in the last century. Both diseases are highly frequent in Western countries and in aged people. Western diet--low in fiber and rich in dietary fat--has been largely regarded to play a major role in the pathogenesis of both conditions. A causal relationship between diverticulosis and CRC has been suggested in different studies. Epidemiologic series found a more frequent rectosigmoid localization of neoplastic lesions (advanced adenoma and CRC) in patients with diverticulosis as compared with controls, particularly in those with a previous diverticulitis episode or with an extensive disease. However, data are still controversial, with other studies failing to confirm this observation. Such discrepancy could be referred to the highly heterogeneous study design and setting in the different epidemiologic series. Pathologic studies showed that either macroscopic and microscopic chronic inflammation--which is regarded as risk factor for CRC development--is present in the colonic mucosa of some patients with diverticula. Moreover, alterations in the extracellular matrix, also involved in colorectal carcinogenesis, have been depicted in diverticulosis. In addition, an upward shifting of cell proliferation occurs in diverticular mucosa, and in nondiverticular patients with advanced adenomas. Finally, aberrant crypt foci--which are considered potential markers of CRC risk in ulcerative colitis--have been detected in colonic mucosa of patients with diverticulosis. Despite this substantial amount of evidence, however, the available data are not yet strong enough to suggest a more aggressive CRC prevention in diverticular as compared with nondiverticular subjects.

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“…Of the 30 studies identiÿed, 16 were excluded from our analyses. Most of the excluded studies examined populations that would not re ect adenoma risk in the North American and European populations [7][8][9][10][11][12][13][14][15][16][17]. These 11 studies primarily examined South American and Asian populations that generally have a lower incidence of colorectal cancer relative to populations in the North America and Europe.…”

Section: Datamentioning

confidence: 99%

A hierarchical non‐homogenous Poisson model for meta‐analysis of adenoma counts

Rutter

Miglioretti

2005

Statistics in Medicine

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We use a hierarchical model for a meta-analysis that combines information from autopsy studies of adenoma prevalence and counts. The studies we included reported findings using a variety of adenoma prevalence groupings and age categories. We use a non-homogeneous Poisson model for multinomial bin probabilities. The Poisson model allows risk to depend on age and sex, and incorporates extra-Poisson variability. We evaluate model fit using the posterior predicted distribution of adenoma prevalence reported by the studies included in our analyses and validate our model using adenoma prevalence reported by more recent colonoscopy studies. For 1990, the estimated adenoma prevalence among Americans at age 60 is 40.3 per cent for men compared to 29.2 per cent for women.

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Cancer and „cancer related”︁ colorectal lesions in São Paulo, Brazil

Cited by 16 publications

References 33 publications

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

Diverticulosis and Colorectal Cancer

A hierarchical non‐homogenous Poisson model for meta‐analysis of adenoma counts

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