Cancer and Goitre

Stocks, Percy

doi:10.1093/biomet/16.3-4.364

Cited by 13 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( a ) Mean diflerence or mean of the corrected differences D/S -D'/S' in pairs, denoted by ma, which is obtained by regarding the differences when they have been computed as all positive in sign, since it is immaterial which child of the pair is taken first. (8) Root mean-square difference, or root mean-square of the corrected differences in the pairs, denoted by a d , since this is also the standard deviation about the mean zero of the symmetrical distribution formed by entering each difference both with a plus and a minus sign.…”

mentioning

confidence: 99%

“…m, = C (D/X)/Zn, where n is the number of pairs and D is always given its correct sign, and also the standard deviations within the various groups, denoted by a , . Having obtained both ad and a , , the correlation coefficients were obtained at once by the formula 104 234 The correction of aa and r for experimental errors is dealt with in section (8). (6) The standard error of estimate a o d lwas also computed for some of the groups, thus measuring the variability of one member of the pair when the other is held constant, an inverse measure of resemblance which has some advantages over either ( a ) , or ( p ) or ( y ) .…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Biometric Investigation of Twins and Their Brothers and Sisters

Stocks¹

1933

Annals of Eugenics

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

A Biometric Investigation of Twins and Their Brothers and Sisters

Stocks¹

1933

Annals of Eugenics

View full text Add to dashboard Cite

show abstract

“…Early analyses established iodine-deficient goiter as a risk factor for GC [56,57]. More recently a significant correlation between goiter and gastric noncardia adenocarcinoma was reported [58].…”

Section: Gastric Cancermentioning

confidence: 99%

The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

Brown

Simmen

2013

IJMS

View full text Add to dashboard Cite

Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled via activation and deactivation by iodothyronine deiodinases in the liver and other tissues. Given that thyroid hormone signaling has been characterized as a major effector of digestive system growth and homeostasis, numerous investigations have examined its role in the occurrence and progression of cancers in various tissues of this organ system. The present review summarizes current findings regarding the effects of thyroid hormone signaling on cancers of the esophagus, stomach, liver, pancreas, and colon. Particular attention is given to the roles of different thyroid hormone receptor isoforms, the novel integrin αVβ3 receptor, and thyroid hormone-related nutrients as possible protective agents and therapeutic targets. Future investigations geared towards a better understanding of thyroid hormone signaling in digestive system cancers may provide preventive or therapeutic strategies to diminish risk, improve outcome and avert recurrence in afflicted individuals.

show abstract

“…In early works, Stocks (8) and Spencer (9) reported that iodine-deficient goitre constitutes a risk factor for gastric cancer. Recently, we reported (10) that iodine deficiency (or excess) might represent a risk factor for gastric cancer and atrophic gastritis, by regulating gastric trophism and by antagonizing (in thyroid cells and in gastric mucosa) the action of several iodine inhibitors such as nitrates, thiocyanates and salt (11), which are well-known risk factors for gastric carcinogenesis.…”

mentioning

confidence: 99%