Cancer as a Metabolic Disorder

Gyamfi, Jones; Kim, Jin‐Young; Choi, Jung‐Ho

doi:10.3390/ijms23031155

Cited by 110 publications

(70 citation statements)

References 105 publications

(223 reference statements)

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“…The incidence of cancers continuously increased in the last few years and cancers have overtaken cardiovascular diseases as the leading cause of death in some high-income countries [ 141 ]. Cancer of the endocrine, digestive, urinary, and immune systems includes breast cancer, liver cancer, gastric cancer, colorectal cancer, prostate cancer, lung cancer, skin cancer, etc.…”

Section: Resultsmentioning

confidence: 99%

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Wang

Zhou

et al. 2022

Molecules

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(1) Background: Dyes play an important role in food, medicine, textile, and other industries, which make human life more colorful. With the increasing demand for food safety, the development of natural dyes becomes more and more attractive. (2) Methods: The literature was searched using the electronic databases PubMed, Web of Science, and SciFinder and this scoping review was carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). (3) Results: 248 articles were included in this review. This review summarizes the research progress on natural dyes in the last ten years. According to structural features, natural dyes mainly include carotenoids, polyphenols, porphyrins, and alkaloids, and some of the newest dyes are summarized. Some pharmacological activities of carotenoids, anthocyanin, curcumin, and betalains in the last 10 years are summarized, and the biological effects of dyes regarding illumination conditions. The disadvantages of natural dyes, including sources, cost, stability, and poor bioavailability, limit their application. Here, some feasible strategies (potential resources, biotechnology, new extraction and separation strategies, strategies for improving stability) are described, which will contribute to the development and utilization of natural dyes. (4) Conclusion: Natural dyes show health benefits and potential in food additives. However, it is necessary for natural dyes to pass toxicity tests and quality tests and receive many regulatory approvals before their final entry into the market as food colorants or as drugs.

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Section: Resultsmentioning

confidence: 99%

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Wang

Zhou

et al. 2022

Molecules

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“…These genes can regulate and interact with metabolic genes, which cause dysfunctional metabolism in different cancer genotypes. So far, 10,000–50,000 different single nucleotide variants of most oncogenes and tumor suppressors in tumor cells have been identified as playing a key role in three major cellular metabolism pathways [ 27 ]. Based on the type of cancer, the pathways of cellular metabolism include (i) aerobic glycolysis, (ii) glutaminyls, and (iii) one-carbon metabolism, needed for rapid cell growth and division.…”

Section: Biomarkers For Metabolic Syndromementioning

confidence: 99%

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Chung

Nguyen

Zhang

et al. 2022

Sensors

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Metabolic syndrome (MS) is a cluster of conditions that increases the probability of heart disease, stroke, and diabetes, and is very common worldwide. While the exact cause of MS has yet to be understood, there is evidence indicating the relationship between MS and the dysregulation of the immune system. The resultant biomarkers that are expressed in the process are gaining relevance in the early detection of related MS. However, sensing only a single analyte has its limitations because one analyte can be involved with various conditions. Thus, for MS, which generally results from the co-existence of multiple complications, a multi-analyte sensing platform is necessary for precise diagnosis. In this review, we summarize various types of biomarkers related to MS and the non-invasively accessible biofluids that are available for sensing. Then two types of widely used sensing platform, the electrochemical and optical, are discussed in terms of multimodal biosensing, figure-of-merit (FOM), sensitivity, and specificity for early diagnosis of MS. This provides a thorough insight into the current status of the available platforms and how the electrochemical and optical modalities can complement each other for a more reliable sensing platform for MS.

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“…Cancer can be defined as a multifactorial and multi-step disease [ 1 ]. From a genetic aspect, a sequence of reported mutations, epigenetic changes and genomic alterations are associated with the deregulation of cell replication, division and growth [ 1 ].…”

Section: Genetical Fundamentals and Metabolic Reprogramming In Cancer...mentioning

confidence: 99%

“…Despite the progress made in prevention, diagnosis and treatment, cancer remains one of the most common causes of mortality worldwide and even represents the leading cause of death over cardiovascular diseases in several high-income countries [ 1 , 2 ]. The cancer burden is expected to keep rising, with a projection of a 61.7% increase in incidence worldwide by the year 2040, according to GLOBOCAN (World Health Organization’s International Agency for Research on Cancer Global Cancer Observatory) data [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…A key point to understanding the current state of cancer-associated mortality and morbidity is that, albeit the advances in cancer biology, the new concepts of neoplastic cell behavior during invasion and metastasis have not been translated into the development of more effective treatments [ 1 ]. Insights into the complexity of carcinogenesis emphasize the need to devise new antitumoral treatments that can target the cancerous cells while decreasing side effects [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite Biobased Materials for Treatment and Diagnosis of Cancer

Lama-Odría

Valle

Puiggalı́

2022

IJMS

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Great advances in cancer treatment have been undertaken in the last years as a consequence of the development of new antitumoral drugs able to target cancer cells with decreasing side effects and a better understanding of the behavior of neoplastic cells during invasion and metastasis. Specifically, drug delivery systems (DDS) based on the use of hydroxyapatite nanoparticles (HAp NPs) are gaining attention and merit a comprehensive review focused on their potential applications. These are derived from the intrinsic properties of HAp (e.g., biocompatibility and biodegradability), together with the easy functionalization and easy control of porosity, crystallinity and morphology of HAp NPs. The capacity to tailor the properties of DLS based on HAp NPs has well-recognized advantages for the control of both drug loading and release. Furthermore, the functionalization of NPs allows a targeted uptake in tumoral cells while their rapid elimination by the reticuloendothelial system (RES) can be avoided. Advances in HAp NPs involve not only their use as drug nanocarriers but also their employment as nanosystems for magnetic hyperthermia therapy, gene delivery systems, adjuvants for cancer immunotherapy and nanoparticles for cell imaging.

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Cancer as a Metabolic Disorder

Cited by 110 publications

References 105 publications

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Hydroxyapatite Biobased Materials for Treatment and Diagnosis of Cancer

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