2023
DOI: 10.1038/s41598-023-43296-3
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Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness

Georgii Vasiukov,
Yong Zou,
Maria-Fernanda Senosain
et al.

Abstract: Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can improve existing diagnostic and treatment strategies. Extracellular matrix (ECM) remodeling and cancer-associated fibroblasts play a crucial role in the regulation of cancer aggressiveness and there is a growing need to investigate their role in the determination of LUAD beh… Show more

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