Cancer-Associated Thrombotic Microangiopathy in a Patient With Metastatic Esophageal Adenocarcinoma

Abstract

The Thrombotic microangiopathy (TMA) syndromes are a group of disorders, extraordinarily diverse, united by common, defining clinical and pathological features [1].The clinical features of TMA include microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. The clinical criterion reflects intravascular hemolysis: schistocytes, increased LDH, decreased haptoglobin, negative Coombs, anemia, thrombocytopenia, and organ injury, with or without kidney failure [1,2]. Thrombocytopenia, schistocytosis, and elevated levels of LDH are enough to form a diagnosis in clinical practice.