Cancer Biology and Pathology

Reddy, G. Prem Veer; Reddy, L. J.; Kim, Sahn‐Ho

doi:10.1002/9781119645214.ch2

Cited by 2 publications

(1 citation statement)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The divergence in clinical outcomes emerges from the unique tissue contexts affected by these shared pathogenic processes. Cancer manifests as uncontrolled cell growth that forms tumors, impacting various organs and tissues [57]. On the contrary, neurodegeneration manifests as the progressive loss of specific neuronal populations, resulting in cognitive decline or motor impairments particular to the affected brain regions [7].…”

Section: Parallel Pathogenesis Divergent Destinies: Double Hitmentioning

confidence: 99%

Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer

Montanari,

Meringolo,

El Atiallah

et al. 2024

Preprint

View full text Add to dashboard Cite

The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While cancer signifies uncontrolled cellular proliferation and neurodegeneration marks progressive neuronal loss, recent insights highlight intriguing interconnections between these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition of replicative immortality, stimulation of blood vessel growth (angiogenesis), and initiation of invasion and metastasis. Conversely, investigations emphasize disrupted cellular energy regulation and evasion of immune surveillance as key traits arising from genome instability, mutations, and inflammation driving tumorigenesis. Neurodegeneration involves neuronal malfunction and depletion, synaptic impairment, and protein abnormalities aggregations contributing to muscle atrophy and cognitive deficits. Varied clinical studies underscore contrasting correlations between cancer and neurodegeneration, hinting at mirrored molecular pathways that foster cell resilience or vulnerability. Research explores cellular signaling in tumorigenesis, shared with neurodegenerative disorders. Aberrant expression or mutations in crucial genes implicated in neurodegeneration also surface in cancer contexts. Debates persist on the nature of the relationship between cancer and neurodegeneration, contemplating inverse associations or shared pathways. Understanding their complex interplay, encompassing genetics, cellular mechanisms, and environmental influences, remains pivotal in unraveling their connections. This review explores the intriguing perspective that neurodegeneration and cancer might share fundamental genetic links, delving into potential implications for their onset and progression.

show abstract

Section: Parallel Pathogenesis Divergent Destinies: Double Hitmentioning

confidence: 99%