Cancer Biomarker Methylmalonic Acid Detection by Molecularly Imprinted Polyaniline Paper Sensor

Abstract

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A novel Co(ii)-based MOF with selective fluorescence as a turn-on sensor for biomarker methylmalonic acid

“…Extensive efforts have been devoted to studying a number of methods for the detection of MMA, such as the high-performance liquid chromatography (HPLC) method, and (ultra-performance) liquid chromatography-tandem mass spectroscopy ((UP)LC-MS/MS) 10–14 However, these techniques are not exactly convenient due to the complexity of the analysis processes. 15 Fabricating a facile detection method with high selectivity is very essential to accurately detect MMA in urine or serum.…”

“…7,8 The detection of MMA has another important role as it can be utilized to analyse methylmalonic acidemia, a genetic condition that occurs in infants and could result in severe toxicity and other health issues. 9 Extensive efforts have been devoted to studying a number of methods for the detection of MMA, such as the highperformance liquid chromatography (HPLC) method, and (ultra-performance) liquid chromatography-tandem mass spectroscopy ((UP)LC-MS/MS) [10][11][12][13][14] However, these techniques are not exactly convenient due to the complexity of the analysis processes. 15 Fabricating a facile detection method with high selectivity is very essential to accurately detect MMA in urine or serum.…”