Cancer Burden in China during 1990–2019: Analysis of the Global Burden of Disease

Zhang, Shuzhen; Zhang, Li; Xie, Long

doi:10.1155/2022/3918045

Cited by 14 publications

(20 citation statements)

References 47 publications

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“…Authoritative research estimates that breast cancer has become the most prevalent cancer type among female cancer patients in the United States, and death also ranks second among female cancer-related death types, with a true proportion of 15% in 2022 ( 33 ). According to the latest data released by the National Cancer Center, the incidence of breast cancer in China is 7.11%, and the mortality rate is 2.81%, ranking fifth and seventh, respectively ( 34 ). Based on the above statistical results, breast cancer is a serious public health issue in current society and needs to be given great attention.…”

Section: Role and Mechanism Of Tmem88 In Malignant Tumorsmentioning

confidence: 99%

Targeting TMEM88 as an Attractive Therapeutic Strategy in Malignant Tumors

Cai

Ni²,

Wang³

et al. 2022

Front. Oncol.

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According to authoritative surveys, the overall morbidity and mortality of malignant tumors show an upward trend, and it is predicted that this trend will not be well contained in the upcoming new period. Since the influencing factors, pathogenesis, and progression characteristics of malignant tumors have not been fully elucidated, the existing treatment strategies, mainly including surgical resection, ablation therapy and chemotherapy, cannot achieve satisfactory results. Therefore, exploring potential therapeutic targets and clarifying their functions and mechanisms in continuous research and practice will provide new ideas and possibilities for the treatment of malignant tumors. Recently, a double-transmembrane protein named transmembrane protein 88 (TMEM88) was reported to regulate changes in downstream effectors by mediating different signaling pathways and was confirmed to be widely involved in cell proliferation, differentiation, apoptosis and tumor progression. At present, abnormal changes in TMEM88 have been found in breast cancer, ovarian cancer, lung cancer, thyroid cancer and other malignant tumors, which has also attracted the attention of tumor research and attempted to clarify its function and mechanism. However, due to the lack of systematic generalization, comprehensive and detailed research results have not been comprehensively summarized. In view of this, this article will describe in detail the changes in TMEM88 in the occurrence and development of malignant tumors, comprehensively summarize the corresponding molecular mechanisms, and explore the potential of targeting TMEM88 in the treatment of malignant tumors to provide valuable candidate targets and promising intervention strategies for the diagnosis and cure of malignant tumors.

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Section: Role and Mechanism Of Tmem88 In Malignant Tumorsmentioning

confidence: 99%

Targeting TMEM88 as an Attractive Therapeutic Strategy in Malignant Tumors

Cai

Ni²,

Wang³

et al. 2022

Front. Oncol.

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“…In China, the prevalence of cancer is rising, 1,2 with the overall incidence increasing by 169% from 1990 to 2019. 3 Besides the most attributable factor for cancer-aging, 4 cancer initiation and development are also influenced by inherited and environmental factors, with the environment playing a significant role in leading to sporadic cancer. 5 Instead of concentrating on inherited risk factors, which are difficult to change, cancer prevention should focus on modifiable factors, such as lifestyle, infectious agents, and air pollution.…”

Section: Introductionmentioning

confidence: 99%

“…In China, the prevalence of cancer is rising, 1,2 with the overall incidence increasing by 169% from 1990 to 2019 3 . Besides the most attributable factor for cancer—aging, 4 cancer initiation and development are also influenced by inherited and environmental factors, with the environment playing a significant role in leading to sporadic cancer 5 .…”

Section: Introductionmentioning

confidence: 99%

Time trends of 16 modifiable risk factors on the burden of major cancers among the Chinese population

Li,

Song,

et al. 2023

Intl Journal of Cancer

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The cancer burden in China is increasing. We aimed to assess the time trends in the prevalence of 16 modifiable risk factors involved in lifestyle, diet, infection, and air pollution between 1997 and 2025 based on the China Health and Nutrition Survey, the Global Burden of Disease website, and publically available studies. The population attributable fraction (PAF) and its 95% uncertainty interval (UI) from 2007 to 2035 were calculated to quantify the attributable cancer burden in major 12 anatomic sites using the comparative risk assessment method, considering a 10‐year lag effect. As a result, 1,559,476 cancer cases (PAF = 54.1%, 95% UI: 36.8%–65.8%) from the 12 anatomic sites were attributable to these modifiable risk factors in 2007, with lung, liver, and gastric cancer raging the top three. It was predicted that by 2035, the attributable cancer cases would reach 1,680,098 (PAF = 44.2%, 95% UI: 29.1%–55.5%), with the top three of lung, liver, and colorectal cancer. Smoking, physical inactivity, insufficient fruit consumption, HBV infection, and Helicobacter pylori infection were the most attributable risk factors in 2007, contributing to 480,352, 233,684, 215,009, 214,455, and 187,305 associated cancer cases, respectively. In 2035, the leading factors for cancer would be smoking, physical inactivity, insufficient fruit intake, HPV infection, and HBV infection, resulting in 427,445, 424,327, 185,144, 156,535, and 154,368 cancer cases, respectively. Intervention strategies should be swiftly established and dynamically altered in response to risk factors like smoking, physical inactivity, poor fruit intake, and infectious factors that may cause a high cancer burden in the Chinese population.

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“…But the conclusions of their causal relationships remain inconclusive. The association of drinking with CRC risk is controversial in the literature (1,2,(7)(8)(9)(10)(11)(12)(13)(14)(15): Some studies have found drinking is associated with increase in CRC risk (1,(7)(8)(9)(10)(11)(12); some have reported drinking beer is associated with decrease in CRC risk (13); and some have reported no association between them (14,15). Drinking prevalence is going up over time and signi cantly different in gender, age and city in China (16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption associated with colorectal cancer risk in a community population aged 50-74 years old: A nested case-control study

Lai,

Zhu,

Gan

et al. 2023

Preprint

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Objective Colorectal cancer (CRC) incidence has been increasing in China and worldwide. Alcohol consumption has been going up in China, too. This study was to investigate whether drinking was associated with CRC risk in a community population aged 50–74. Methods We designed a case-control study nested in a mass CRC screening program from 2020 to 2022. Cases were defined as newly diagnosed CRC confirmed by histopathological examinations and controls were normal people without any colorectal diseases confirmed by colonoscopy. Logistic regressions were used to estimate OR and 95% confidence interval (CI) of drinking between cases and controls. Results Using never drinking in their lifetime as a common reference, the adjusted OR and 95% CI of drinking between cases and controls were 1.45 (0.92, 2.30) in current drinkers, 3.90 (1.47, 10.34) in former drinkers, 1.55 (1.01, 2.38) in drinking 6–7 days/week, and 4.18 (1.41, 12.43) in drinking 1–19 years. When stratifying by gender, all drinking variables in women but not all in men were consistently associated with CRC risk; the adjusted OR and 95% CI were 1.01 (0.59, 1.74) in current drinking men, 2.27 (0.78, 6.64) in former drinking men, and 4.24 (1.61, 11.13) in current drinking women; the adjusted OR and 95% CI of drinking whisky amount were 0.19 (0.04, 0.83), 1.89 (0.86, 4.17), 2.25 (1.05, 4.83), and 1.82 (0.85, 3.92) in men drinking ≤ 10, 11-≤20, 21-≤30, > 30 Liang/week with a Ptrend = 0.011, and 4.03 (1.24, 13.12) and 7.40 (1.88, 29.15) in women drinking 1–4 days/week and 5–7 days/week with a Ptrend < 0.001, respectively. Conclusion Alcohol consumption was associated with increase in CRC risk in a community population aged 50–74. There were gender disparities in drinking and its association with CRC risk. Women tended to be more sensitive to alcohol carcinogenesis in CRC than men did and men’s association of drinking whisky with CRC risk tended to be determined by dosage.

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Cancer Burden in China during 1990–2019: Analysis of the Global Burden of Disease

Cited by 14 publications

References 47 publications

Targeting TMEM88 as an Attractive Therapeutic Strategy in Malignant Tumors

Targeting TMEM88 as an Attractive Therapeutic Strategy in Malignant Tumors

Time trends of 16 modifiable risk factors on the burden of major cancers among the Chinese population

Alcohol consumption associated with colorectal cancer risk in a community population aged 50-74 years old: A nested case-control study

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