Cancer cell membrane-camouflaged CuPt nanoalloy boosts chemotherapy of cisplatin prodrug to enhance anticancer effect and reverse cisplatin resistance of tumor

Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

“…Breast cancer cells were used to target homologous cells and deliver cargo [6]. Similarly, colon carcinoma [57] head and neck squamous cell carcinoma [58], lung cancer [54], glioma [63,64], glioblastoma [65,66], prostate cancer [67], and liver cancer [68] cells were selected for homologous targeting, ensuring precision in cargo delivery to specific tissues. The choice of materials for each of these crucial steps depends on the specific tissue being targeted and the nature of the treatment under investigation.…”

“…M any different cell types have been used for nanoparticle membrane coating (Table 1). Notably, a range of cancer lines has been used, including cervical and ovarian cancers [21][22][23][24], multiple myeloma [25], melanoma [12,[26][27][28][29][30][31][32], leukemia [23,[33][34][35][36][37][38][39][40][41][42][43][44], breast cancer [6,37,40,[45][46][47][48][49][50][51][52][53][54][55][56], neuroblastoma [79], colon carcinoma [23,57], head and neck squamous cell carcinoma [58][59][60][61], lung cancer…”

“…Most researchers employed hypotonic lysis in their studies [6,12,19,[21][22][23][24][25][26][27][29][30][31][32][33][34][35][36]38,39,[41][42][43][44][45][48][49][50][51][54][55][56][57][58][60][61][62][63][64][65][66][67][69][70][71][72][73][74][75][76][77]79,81,…”

“…This lysis method involves resuspending the utilized cells in a hypotonic solution containing low concentrations of salts and protease or phosphatase inhibitors. Several authors used a hypotonic lysis buffer with 20 mM Tris-HCl pH 7.5, 10 mM KCl, 2 mM MgCl 2 , and 1 EDTA-free mini protease inhibitor tablet per 10 mL of solution [12,23,25,34,44,45,51,54,56,58,67,72,95]. Parodi et al drew upon the use of the same salts as Qu et al, but adding 25 mM of sucrose and using PMSF and trypsin-chymotrypsin inhibitors [92].…”

l-Cysteine-Triggered Regulation of the Mitochondrial Energy Metabolism To Enhance Chemotherapy of Triple-Negative Breast Cancer

“…GSH is a significantly important antioxidant in tumor cells and can deactivate cisplatin. − l -cysteine is a raw material in GSH synthesis with ATP providing the energy required for synthesis. DNPA was observed to consume l -cysteine as well as inhibit ATP production (as shown in Figures f and g), both of which were unfavorable for GSH synthesis.…”