Cancer Cell Membrane Camouflaged Semi‐Yolk@Spiky‐Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy

Zhou, Mengyun; Xing, Yi; Li, Xiaoyü; Du, Xin; Xu, Tailin; Zhang, Xueji

doi:10.1002/smll.202003834

Cited by 62 publications

(49 citation statements)

References 56 publications

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“…Zhou et al demonstrated how cell membrane coating, sourced from MCF-7 cancer cells, promoted the selfthermophoretic motion of NIR light-driven semi-yolk@spiky shell carbon@silica nanomotors loaded with DOX to treat cancers (Figure 10A). [98] Such MC@SiO2@DOX motors were assessed in their photothermal and chemotherapeutic therapy of breast cancer (Figure 10B). The cell membrane camouflaged the motors, reduced bio-adhesion, and thus lowered their resistance to propel in the viscous cell culture media.…”

Section: Photothermal Therapymentioning

confidence: 99%

Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications

et al. 2021

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efficient operation in the physiological environment without producing any unintended harmful consequences.Combining the advantages of the dynamic movement of synthetic motors with the versatility and unique biological functions of natural cells leads to celllike micromotors that enable new opportunities for overcoming many obstacles that synthetic motors currently face in numerous biomedical operations. [10,11] By taking inspiration from nature, essential biological functions of natural cells, such as immune stealth, faithful antigen presentation, cell-or tissue-specific targeting, and selective binding with bacterial toxins or pathogens, can thus be harnessed and imparted to mobile synthetic microsystems. Cell membrane coating represents a powerful top-down approach for replicating complex protein profiles and biological functions of host cell membrane that are otherwise impractical to achieve with bottom-up synthetic approaches. The cell membrane-synthetic motor coupling results in novel active biocompatible devices, offering synergistic functionalities and new capabilities for a broad range of applications. In particular, recent attention has been given to cell membrane-functionalized micromotors. [12,13] In this review, we discuss the preparation, unique capabilities, and advantages of biomimetic micromotors, leveraging the attractive properties of cell membrane-derived biomaterials and dynamic synthetic micromotors. Cellular membranes play crucial roles in the interface of cells with their complex surrounding biological environment. [14] The use of natural cell membranes to functionalize micromotors has been shown recently to address major barriers (e.g., biofouling) that hinder in vivo operations of synthetic motors while rendering them with a wide range of new properties and unique capabilities that greatly enhance their performance in biological systems. For instance, the cell membrane-functionalized micro motors can achieve prolonged propulsion in complex biofluids and efficient neutralization of harmful agents through the cell membrane receptors. This new class of biomimetic microscale motors thus combines the merits of synthetic motors with those of natural cell membranes. The diversity of different types of cell membranes and their associated biological functionalities enables the development of numerous biomimetic micromotor platforms with broad applicability. The judicious coupling of these different types of cell membranes with various types of There has been considerable interest in developing synthetic micromotors with biofunctional, versatile, and adaptive capabilities for biomedical applications. In this perspective, cell membrane-functionalized micromotors emerge as an attractive platform. This new class of micromotors demonstrates enhanced propulsion and compelling performance in complex biological environments, making them suitable for various in vivo applications, including drug delivery, detoxification, immune modulation, and phototherapy. This article reviews various proof-of-concept stu...

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Section: Photothermal Therapymentioning

confidence: 99%

Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications

et al. 2021

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“…Upon exposure to a NIR light, a thermal gradient across the NPs is generated due to asymmetric carbon core, which propels their motion by self-thermophoretic mechanism (Figure 10B). [77] Recently, our group has also fabricated an asymmetric multilayer-sandwich mesoporous nanobottle-shaped Figure 10. Construction of core-shell structured mesoporous MNMs.…”

Section: Functional Mesoporous Materials As Shellsmentioning

confidence: 99%

Core‐Shell Structured Micro‐Nanomotors: Construction, Shell Functionalization, Applications, and Perspectives

Yan

Liang

Zhao

et al. 2021

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magnetic [2] or electric fields, [3] light, [4] and ultrasonic waves [5] into kinetic force. These synthetic smart machines could potentially lead to the development of new technologies for diverse applications ranging from smart sensing, [6] to environmental remediation, [7] drug delivery, biological surgeries, [8] and many other promising applications. One important challenge, often faced by scientists working in the field of MNMs, is the development of MNM systems with nontoxic chemical fuels for chemically propelled MNMs, well-controlled directionality, multifunctionality, fast motion, fully compatible, and biodegradable (when applied to biological applications). This issue, as a whole or in part, could be addressed by developing MNM systems with core-shell structural characteristics. The performances of MNMs are strongly dependent on the size, geometrical shape, surface property, as well as, composition of individual components. [9] Core-shell structured MNM systems have a well-controlled manner in these aspects, and thus are the most popular morphology and the most commonly used in various applications. Particularly, core-shell structured MNMs address most disadvantages presented by other singlecomponent MNM structures. They can integrate multiple functions into one common structure and often bring improved and complementary properties, and even new synergistic functions depending on the interactions between the cores and shells, which are unavailable from the isolated components. [4b,10] Coreshell structured MNM systems will be expected as integrated equipment to achieve communication and cooperation and further perform more complex tasks.Earlier core-shell architectures were mainly the concentric multilayer nanostructures composed of cores (inner components) and shells (outer layer components), which is the simplest motif in core-shell nanomaterial systems. [11] To meet the growing demand in diverse applications, core-shell structured MNMs have recently been evolved from simple single-level to complex multilevel architectures (Figure 1). Depending on the geometry, core-shell nanostructures typically can be divided into four categories: core-shell structure (core@shell), Janus structure (eccentric core@shell), hollow core-shell structure (void@ shell), and yolk-shell structure (core@void@shell). The central task in obtaining core-shell nanostructures is minimizing the core-shell interfacial tension by rational selection of ligand,The successful integration of well-designed micro-nanomotors (MNMs) with diverse functional systems, such as, living systems, remote actuation systems, intelligent sensors, and sensing systems, offers many opportunities to not only endow them with diverse functionalization interfaces but also bring augmented or new properties in a wide variety of applications. Core-shell structured MNM systems have been considered to play an important role in a wide range of applications as they provide a platform to integrate multiple complementary components via decoration, encapsulation, o...

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“…In a unique study, Zhau et al showed, for the first time, the use of core-shell NIR light-driven nanocarrier to enhance the thermophoretic movement of the particle inside the cell. [63] The Spiky-shell silica nanocarrier with carbon core is used, which has NIR light-driven thermo-phoretic properties. Dox is loaded as a drug, and the MCF-7 cell membrane was used to coat the nanocarrier.…”

Section: Homotypic Targeting Based Chemotherapymentioning

confidence: 99%

Cancer Cell Membrane Technology for Cancer Therapy

et al. 2020

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Even after decades of research, one of the most significant challenges in nanotechnology-based cancer therapy is to increase the target specificity and to reduce the side effects. As a result, even after substantial progress in lab-scale research, clinical trials have mostly failed. One of the emerging new strategies to increase the target specificity and to increase the chemotherapeutic efficacy is to mimic biological moieties using cellular membranes. Owing to its preferential accumulation at the tumor site, cancer cell membrane presents itself as a promising surface functionalization to the nanocarriers. This review aims to summarize recent reports on the cancer cell membrane and the hybrid membrane-associated research for the comprehensive understanding of their successful implementation in cancer therapy.

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Cancer Cell Membrane Camouflaged Semi‐Yolk@Spiky‐Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy

Cited by 62 publications

References 56 publications

Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications

Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications

Core‐Shell Structured Micro‐Nanomotors: Construction, Shell Functionalization, Applications, and Perspectives

Cancer Cell Membrane Technology for Cancer Therapy

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